AbstractIn this thesis mechanisms underlying bladder mechanosensation were investigated both directly, using an in vitro afferent nerve recording technique which allowed the concurrent recording of intravesical pressure and afferent nerve activity, and indirectly, examining urothelial mediator release and intracellular calcium signaling of urothelial cells and isolated DRG neurons. Using a combination of mechanical, pharmacological and genetic tools, a role for P2X, P2Y, TRPV1 and NK2 receptors in influencing mechanosensitivity was investigated.
|Date of Award||11 Oct 2014|
|Supervisor||Russ Chess-Williams (Supervisor) & Donna Sellers (Supervisor)|
Non-Neuronal ATP: Regulation of Release and Action in the Bladder
Grundy, L. (Author). 11 Oct 2014
Student thesis: Doctoral Thesis