Highly degraded biological samples may be encountered in cases of mass disasters, missing persons cases, and forensic casework. As biological tissue degrades, DNA becomes progressively more fragmented and a decrease in the ability to gain an accurate DNA profile results. The successful typing of highly degraded DNA can be further complicated by also having chemical modifications (DNA damage). Such highly degraded samples often produce incomplete or no STR profiles. Alternate genotyping strategies such as mini-STRs and SNPs have proven to be more successful in profiling such difficult samples and were therefore investigated in this thesis.
|Date of Award||9 Feb 2013|
|Supervisor||Angela Van Daal (Supervisor) & Kevin John Ashton (Supervisor)|