Abstract
Neural circuits in the central nervous system are the substrate of various high-order brain functions. Anatomical and functional graph structures of neural networks with actual connections will provide us with perspectives to elucidate the brain complex system. Here, we aim to develop a three-dimensional mouse brain atlas of neural circuits using high resolution x-ray tomography by synchrotron radiation. It will not only identify a large number of synapses but also clarify the structure of neuronal networks for understanding the most complicated organ in the body. In this study, a nano-resolution full-field x-ray microscope revealed nerve fibers and organelles including mitochondria and synapses in the mouse cerebral cortex. Fig. a shows chematic layout of the x-ray optical system and Fig. b demonstrated soft x-ray micrograph of the neural tissue slice. In the near future, we will utilize that information to begin deciphering the wiring diagram of the brain by applying the nano-resolution x-ray tomography.
Original language | English |
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Publication status | Published - 15 Nov 2010 |
Externally published | Yes |
Event | 40th Annual Meeting of the Society for Neuroscience - San Diego, United States Duration: 13 Nov 2010 → 17 Nov 2010 Conference number: 40 |
Conference
Conference | 40th Annual Meeting of the Society for Neuroscience |
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Country/Territory | United States |
City | San Diego |
Period | 13/11/10 → 17/11/10 |