Waist circumference cut-off values for the prediction of cardiovascular risk in Chinese school-aged children: A cross-sectional study

Ailing Liu, Andrew Hills, Xiaoqui Hu, Yan Liu, Lin Du, Ying Xu, Nuala Byrne, Guansheng Ma

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27 Citations (Scopus)

Abstract

Background. Waist circumference has been identified as a valuable predictor of cardiovascular risk in children. The development of waist circumference percentiles and cut-offs for various ethnic groups are necessary because of differences in body composition. The purpose of this study was to develop waist circumference percentiles for Chinese children and to explore optimal waist circumference cut-off values for predicting cardiovascular risk factors clustering in this population. Methods. Height, weight, and waist circumference were measured in 5529 children (2830 boys and 2699 girls) aged 6-12 years randomly selected from southern and northern China. Blood pressure, fasting triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and glucose were obtained in a subsample (n = 1845). Smoothed percentile curves were produced using the LMS method. Receiver-operating characteristic analysis was used to derive the optimal age- and gender-specific waist circumference thresholds for predicting the clustering of cardiovascular risk factors. Results. Gender-specific waist circumference percentiles were constructed. The waist circumference thresholds were at the 90th and 84th percentiles for Chinese boys and girls respectively, with sensitivity and specificity ranging from 67% to 83%. The odds ratio of a clustering of cardiovascular risk factors among boys and girls with a higher value than cut-off points was 10.349 (95% confidence interval 4.466 to 23.979) and 8.084 (95% confidence interval 3.147 to 20.767) compared with their counterparts. Conclusions. Percentile curves for waist circumference of Chinese children are provided. The cut-off point for waist circumference to predict cardiovascular risk factors clustering is at the 90th and 84th percentiles for Chinese boys and girls, respectively.
Original languageEnglish
JournalBMC Public Health
Volume10
Issue number82
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Waist Circumference
Cross-Sectional Studies
Cluster Analysis
Confidence Intervals
Body Composition
Ethnic Groups
ROC Curve
LDL Cholesterol
HDL Cholesterol
Fasting
China
Triglycerides
Odds Ratio
Blood Pressure
Weights and Measures
Glucose
Sensitivity and Specificity

Cite this

Liu, Ailing ; Hills, Andrew ; Hu, Xiaoqui ; Liu, Yan ; Du, Lin ; Xu, Ying ; Byrne, Nuala ; Ma, Guansheng. / Waist circumference cut-off values for the prediction of cardiovascular risk in Chinese school-aged children : A cross-sectional study. In: BMC Public Health. 2010 ; Vol. 10, No. 82.
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title = "Waist circumference cut-off values for the prediction of cardiovascular risk in Chinese school-aged children: A cross-sectional study",
abstract = "Background. Waist circumference has been identified as a valuable predictor of cardiovascular risk in children. The development of waist circumference percentiles and cut-offs for various ethnic groups are necessary because of differences in body composition. The purpose of this study was to develop waist circumference percentiles for Chinese children and to explore optimal waist circumference cut-off values for predicting cardiovascular risk factors clustering in this population. Methods. Height, weight, and waist circumference were measured in 5529 children (2830 boys and 2699 girls) aged 6-12 years randomly selected from southern and northern China. Blood pressure, fasting triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and glucose were obtained in a subsample (n = 1845). Smoothed percentile curves were produced using the LMS method. Receiver-operating characteristic analysis was used to derive the optimal age- and gender-specific waist circumference thresholds for predicting the clustering of cardiovascular risk factors. Results. Gender-specific waist circumference percentiles were constructed. The waist circumference thresholds were at the 90th and 84th percentiles for Chinese boys and girls respectively, with sensitivity and specificity ranging from 67{\%} to 83{\%}. The odds ratio of a clustering of cardiovascular risk factors among boys and girls with a higher value than cut-off points was 10.349 (95{\%} confidence interval 4.466 to 23.979) and 8.084 (95{\%} confidence interval 3.147 to 20.767) compared with their counterparts. Conclusions. Percentile curves for waist circumference of Chinese children are provided. The cut-off point for waist circumference to predict cardiovascular risk factors clustering is at the 90th and 84th percentiles for Chinese boys and girls, respectively.",
author = "Ailing Liu and Andrew Hills and Xiaoqui Hu and Yan Liu and Lin Du and Ying Xu and Nuala Byrne and Guansheng Ma",
year = "2010",
doi = "10.1186/1471-2458-10-82",
language = "English",
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journal = "BMC Public Health",
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Waist circumference cut-off values for the prediction of cardiovascular risk in Chinese school-aged children : A cross-sectional study. / Liu, Ailing; Hills, Andrew; Hu, Xiaoqui; Liu, Yan; Du, Lin; Xu, Ying; Byrne, Nuala; Ma, Guansheng.

In: BMC Public Health, Vol. 10, No. 82, 2010.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Waist circumference cut-off values for the prediction of cardiovascular risk in Chinese school-aged children

T2 - A cross-sectional study

AU - Liu, Ailing

AU - Hills, Andrew

AU - Hu, Xiaoqui

AU - Liu, Yan

AU - Du, Lin

AU - Xu, Ying

AU - Byrne, Nuala

AU - Ma, Guansheng

PY - 2010

Y1 - 2010

N2 - Background. Waist circumference has been identified as a valuable predictor of cardiovascular risk in children. The development of waist circumference percentiles and cut-offs for various ethnic groups are necessary because of differences in body composition. The purpose of this study was to develop waist circumference percentiles for Chinese children and to explore optimal waist circumference cut-off values for predicting cardiovascular risk factors clustering in this population. Methods. Height, weight, and waist circumference were measured in 5529 children (2830 boys and 2699 girls) aged 6-12 years randomly selected from southern and northern China. Blood pressure, fasting triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and glucose were obtained in a subsample (n = 1845). Smoothed percentile curves were produced using the LMS method. Receiver-operating characteristic analysis was used to derive the optimal age- and gender-specific waist circumference thresholds for predicting the clustering of cardiovascular risk factors. Results. Gender-specific waist circumference percentiles were constructed. The waist circumference thresholds were at the 90th and 84th percentiles for Chinese boys and girls respectively, with sensitivity and specificity ranging from 67% to 83%. The odds ratio of a clustering of cardiovascular risk factors among boys and girls with a higher value than cut-off points was 10.349 (95% confidence interval 4.466 to 23.979) and 8.084 (95% confidence interval 3.147 to 20.767) compared with their counterparts. Conclusions. Percentile curves for waist circumference of Chinese children are provided. The cut-off point for waist circumference to predict cardiovascular risk factors clustering is at the 90th and 84th percentiles for Chinese boys and girls, respectively.

AB - Background. Waist circumference has been identified as a valuable predictor of cardiovascular risk in children. The development of waist circumference percentiles and cut-offs for various ethnic groups are necessary because of differences in body composition. The purpose of this study was to develop waist circumference percentiles for Chinese children and to explore optimal waist circumference cut-off values for predicting cardiovascular risk factors clustering in this population. Methods. Height, weight, and waist circumference were measured in 5529 children (2830 boys and 2699 girls) aged 6-12 years randomly selected from southern and northern China. Blood pressure, fasting triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and glucose were obtained in a subsample (n = 1845). Smoothed percentile curves were produced using the LMS method. Receiver-operating characteristic analysis was used to derive the optimal age- and gender-specific waist circumference thresholds for predicting the clustering of cardiovascular risk factors. Results. Gender-specific waist circumference percentiles were constructed. The waist circumference thresholds were at the 90th and 84th percentiles for Chinese boys and girls respectively, with sensitivity and specificity ranging from 67% to 83%. The odds ratio of a clustering of cardiovascular risk factors among boys and girls with a higher value than cut-off points was 10.349 (95% confidence interval 4.466 to 23.979) and 8.084 (95% confidence interval 3.147 to 20.767) compared with their counterparts. Conclusions. Percentile curves for waist circumference of Chinese children are provided. The cut-off point for waist circumference to predict cardiovascular risk factors clustering is at the 90th and 84th percentiles for Chinese boys and girls, respectively.

U2 - 10.1186/1471-2458-10-82

DO - 10.1186/1471-2458-10-82

M3 - Article

VL - 10

JO - BMC Public Health

JF - BMC Public Health

SN - 1471-2458

IS - 82

ER -