Variability in depressive symptoms of cognitive deficit and cognitive bias during the first 2 years after diagnosis in Australian men with prostate cancer

Christopher F. Sharpley, Vicki Bitsika, David R H Christie

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

The incidence and contribution to total depression of the depressive symptoms of cognitive deficit and cognitive bias in prostate cancer (PCa) patients were compared from cohorts sampled during the first 2 years after diagnosis. Survey data were collected from 394 patients with PCa, including background information, treatments, and disease status, plus total scores of depression and scores for subscales of the depressive symptoms of cognitive bias and cognitive deficit via the Zung Self-Rating Depression Scale. The sample was divided into eight 3-monthly time-since-diagnosis cohorts and according to depression severity. Mean scores for the depressive symptoms of cognitive deficit were significantly higher than those for cognitive bias for the whole sample, but the contribution of cognitive bias to total depression was stronger than that for cognitive deficit. When divided according to overall depression severity, patients with clinically significant depression showed reversed patterns of association between the two subsets of cognitive symptoms of depression and total depression compared with those patients who reported less severe depression. Differences in the incidence and contribution of these two different aspects of the cognitive symptoms of depression for patients with more severe depression argue for consideration of them when assessing and diagnosing depression in patients with PCa. Treatment requirements are also different between the two types of cognitive symptoms of depression, and several suggestions for matching treatment to illness via a personalized medicine approach are discussed.

Original languageEnglish
Pages (from-to)6-13
Number of pages8
JournalAmerican Journal of Men's Health
Volume10
Issue number1
Early online date7 Oct 2014
DOIs
Publication statusPublished - 1 Jan 2016

Fingerprint

Prostatic Neoplasms
deficit
cancer
Depression
trend
Neurobehavioral Manifestations
incidence
Precision Medicine
Incidence
illness
rating
medicine
Therapeutics
Disease

Cite this

@article{8f81a7538eda4172a8e3c3a2ecd7f8eb,
title = "Variability in depressive symptoms of cognitive deficit and cognitive bias during the first 2 years after diagnosis in Australian men with prostate cancer",
abstract = "The incidence and contribution to total depression of the depressive symptoms of cognitive deficit and cognitive bias in prostate cancer (PCa) patients were compared from cohorts sampled during the first 2 years after diagnosis. Survey data were collected from 394 patients with PCa, including background information, treatments, and disease status, plus total scores of depression and scores for subscales of the depressive symptoms of cognitive bias and cognitive deficit via the Zung Self-Rating Depression Scale. The sample was divided into eight 3-monthly time-since-diagnosis cohorts and according to depression severity. Mean scores for the depressive symptoms of cognitive deficit were significantly higher than those for cognitive bias for the whole sample, but the contribution of cognitive bias to total depression was stronger than that for cognitive deficit. When divided according to overall depression severity, patients with clinically significant depression showed reversed patterns of association between the two subsets of cognitive symptoms of depression and total depression compared with those patients who reported less severe depression. Differences in the incidence and contribution of these two different aspects of the cognitive symptoms of depression for patients with more severe depression argue for consideration of them when assessing and diagnosing depression in patients with PCa. Treatment requirements are also different between the two types of cognitive symptoms of depression, and several suggestions for matching treatment to illness via a personalized medicine approach are discussed.",
author = "Sharpley, {Christopher F.} and Vicki Bitsika and Christie, {David R H}",
year = "2016",
month = "1",
day = "1",
doi = "10.1177/1557988314552669",
language = "English",
volume = "10",
pages = "6--13",
journal = "American Journal of Men's Health",
issn = "1557-9883",
publisher = "SAGE Publications Ltd",
number = "1",

}

Variability in depressive symptoms of cognitive deficit and cognitive bias during the first 2 years after diagnosis in Australian men with prostate cancer. / Sharpley, Christopher F.; Bitsika, Vicki; Christie, David R H.

In: American Journal of Men's Health, Vol. 10, No. 1, 01.01.2016, p. 6-13.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Variability in depressive symptoms of cognitive deficit and cognitive bias during the first 2 years after diagnosis in Australian men with prostate cancer

AU - Sharpley, Christopher F.

AU - Bitsika, Vicki

AU - Christie, David R H

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The incidence and contribution to total depression of the depressive symptoms of cognitive deficit and cognitive bias in prostate cancer (PCa) patients were compared from cohorts sampled during the first 2 years after diagnosis. Survey data were collected from 394 patients with PCa, including background information, treatments, and disease status, plus total scores of depression and scores for subscales of the depressive symptoms of cognitive bias and cognitive deficit via the Zung Self-Rating Depression Scale. The sample was divided into eight 3-monthly time-since-diagnosis cohorts and according to depression severity. Mean scores for the depressive symptoms of cognitive deficit were significantly higher than those for cognitive bias for the whole sample, but the contribution of cognitive bias to total depression was stronger than that for cognitive deficit. When divided according to overall depression severity, patients with clinically significant depression showed reversed patterns of association between the two subsets of cognitive symptoms of depression and total depression compared with those patients who reported less severe depression. Differences in the incidence and contribution of these two different aspects of the cognitive symptoms of depression for patients with more severe depression argue for consideration of them when assessing and diagnosing depression in patients with PCa. Treatment requirements are also different between the two types of cognitive symptoms of depression, and several suggestions for matching treatment to illness via a personalized medicine approach are discussed.

AB - The incidence and contribution to total depression of the depressive symptoms of cognitive deficit and cognitive bias in prostate cancer (PCa) patients were compared from cohorts sampled during the first 2 years after diagnosis. Survey data were collected from 394 patients with PCa, including background information, treatments, and disease status, plus total scores of depression and scores for subscales of the depressive symptoms of cognitive bias and cognitive deficit via the Zung Self-Rating Depression Scale. The sample was divided into eight 3-monthly time-since-diagnosis cohorts and according to depression severity. Mean scores for the depressive symptoms of cognitive deficit were significantly higher than those for cognitive bias for the whole sample, but the contribution of cognitive bias to total depression was stronger than that for cognitive deficit. When divided according to overall depression severity, patients with clinically significant depression showed reversed patterns of association between the two subsets of cognitive symptoms of depression and total depression compared with those patients who reported less severe depression. Differences in the incidence and contribution of these two different aspects of the cognitive symptoms of depression for patients with more severe depression argue for consideration of them when assessing and diagnosing depression in patients with PCa. Treatment requirements are also different between the two types of cognitive symptoms of depression, and several suggestions for matching treatment to illness via a personalized medicine approach are discussed.

UR - http://www.scopus.com/inward/record.url?scp=84948823468&partnerID=8YFLogxK

U2 - 10.1177/1557988314552669

DO - 10.1177/1557988314552669

M3 - Article

VL - 10

SP - 6

EP - 13

JO - American Journal of Men's Health

JF - American Journal of Men's Health

SN - 1557-9883

IS - 1

ER -