Validation of bioelectrical impedance analysis for total body water assessment against the deuterium dilution technique in Asian children

Qiong A Liu, N. M. Byrne, G. Ma, L. Nasreddine, T. P. Trinidad, K. Kijboonchoo, M. N. Ismail, M. Kagawa, B. K. Poh, A. P. Hills*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)


Background/Objectives: To develop and cross-validate bioelectrical impedance analysis (BIA) prediction equations of total body water (TBW) and fat-free mass (FFM) for Asian pre-pubertal children from China, Lebanon, Malaysia, Philippines and Thailand. Subjects/Methods: Height, weight, age, gender, resistance and reactance measured by BIA were collected from 948 Asian children (492 boys and 456 girls) aged 8-10 years from the five countries. The deuterium dilution technique was used as the criterion method for the estimation of TBW and FFM. The BIA equations were developed using stepwise multiple regression analysis and cross-validated using the Bland-Altman approach. Results: The BIA prediction equation for the estimation of TBW was as follows: TBW=0.231 × height 2/resistance+ 0.066 × height+0.188 × weight+0.128 × age+0.500 × sex-0.316 × Thais-4.574 (R 2=88.0%, root mean square error (RMSE)=1.3 kg), and for the estimation of FFM was as follows: FFM=0.299 × height 2/ resistance+0.086 × height+0.245 × weight+0.260 × age+0.901 × sex-0.415 × ethnicity (Thai ethnicity = 1, others = 0)-6.952 (R 2 88.3%, RMSE=1.7 kg). No significant difference between measured and predicted values for the whole cross-validation sample was found. However, the prediction equation for estimation of TBW/FFM tended to overestimate TBW/FFM at lower levels whereas underestimate at higher levels of TBW/FFM. Accuracy of the general equation for TBW and FFM was also valid at each body mass index category.Conclusions:Ethnicity influences the relationship between BIA and body composition in Asian pre-pubertal children. The newly developed BIA prediction equations are valid for use in Asian pre-pubertal children.

Original languageEnglish
Pages (from-to)1321-1327
Number of pages7
JournalEuropean Journal of Clinical Nutrition
Issue number12
Publication statusPublished - Dec 2011
Externally publishedYes


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