Breathlessness is a distressing symptom that is often seen in palliative care patients with respiratory failure and it can make care in the home setting difﬁcult. Humidiﬁed High Flow Nasal Oxygen is a relatively new intervention for respiratory failure, but it has not been researched greatly in a palliative care setting. One device with the capacity to deliver high ﬂow humidiﬁed oxygen to spontaneously breathing patients is the myAIRVO2 humidiﬁer. The myAIRVO2 is a humidiﬁer with an integrated ﬂow generator that delivers warmed and humidiﬁed respiratory gases to a spontaneously breathing patient. The following case report describes how the technology was used at home for symptom control in a 76 year old patient with severe chronic obstructive pulmonary disease with associated pulmonary hypertension. The patient was successfully discharged from hospital and managed at home using high-ﬂow nasal oxygen for approximately one month up until his death. In this last month of life, he reported that he was more comfortable on high-ﬂow nasal oxygen than on traditionally-administered oxygen. Humidiﬁed High Flow Nasal Oxygen is potentially beneﬁcial to aid in symptom control for palliative care patients in an inpatient and community setting.