Trophoblast Cell Differentiation: Expression of the Placental Prolactin Family

Michael J. Soares, Teresa N Faria, Gary P Hamlin, Xing Jian Lu, Santanu Deb

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Normal growth and maturation of a specialized extraembryonic structure, the placenta, are essential for the establishment and maintenance of pregnancy. The placenta acts as the interface between maternal and embryonic compartments, developing in parallel with the embryo and facilitating the acquisition of maternal resources required for embryonic and fetal development. This essential responsibility of the placenta is accomplished in a number of important ways, including (i) regulation of the transport of nutrients and wastes, (ii) an immunologic role in preventing fetal rejection, and (iii) an endocrine/communication/signaling role between fetal and maternal compartments. Consequently, understanding the control of placental development is fundamental to an appreciation of the initiation and maintenance of pregnancy and various abnormalities associated with altered growth and development. The cells responsible for these diverse functions of the placenta are trophoblast cells.
Original languageEnglish
Title of host publicationTrophoblast Cells
Subtitle of host publicationPathways for Maternal-Embryonic Communication
EditorsMichael J. Soares, Stuart Handwerger, Frank Talamantes
Place of PublicationNew York
PublisherSpringer
Chapter4
Pages45-67
Number of pages23
ISBN (Electronic)978-1-4612-2718-2
ISBN (Print)978-1-4612-7641-8
DOIs
Publication statusPublished - 1993
Externally publishedYes

Publication series

NameProceedings in the Serono Sympsia, USA Series
PublisherSpringer-Verlag

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