Normal growth and maturation of a specialized extraembryonic structure, the placenta, are essential for the establishment and maintenance of pregnancy. The placenta acts as the interface between maternal and embryonic compartments, developing in parallel with the embryo and facilitating the acquisition of maternal resources required for embryonic and fetal development. This essential responsibility of the placenta is accomplished in a number of important ways, including (i) regulation of the transport of nutrients and wastes, (ii) an immunologic role in preventing fetal rejection, and (iii) an endocrine/communication/signaling role between fetal and maternal compartments. Consequently, understanding the control of placental development is fundamental to an appreciation of the initiation and maintenance of pregnancy and various abnormalities associated with altered growth and development. The cells responsible for these diverse functions of the placenta are trophoblast cells.
|Title of host publication||Trophoblast Cells|
|Subtitle of host publication||Pathways for Maternal-Embryonic Communication|
|Editors||Michael J. Soares, Stuart Handwerger, Frank Talamantes|
|Place of Publication||New York|
|Number of pages||23|
|Publication status||Published - 1993|
|Name||Proceedings in the Serono Sympsia, USA Series|