@article{0edf962e0b604e73ac7dbeb7230e3566,
title = "Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction",
abstract = "Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84–5.29) for men of European ancestry to 3.74 (95% CI, 3.36–4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14–2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71–0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.",
author = "Conti, {David V.} and Darst, {Burcu F.} and Moss, {Lilit C.} and Saunders, {Edward J.} and Xin Sheng and Alisha Chou and Schumacher, {Fredrick R.} and Olama, {Ali Amin Al} and Sara Benlloch and Tokhir Dadaev and {The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium} and Brook, {Mark N.} and Ali Sahimi and Hoffmann, {Thomas J.} and Atushi Takahashi and Koichi Matsuda and Yukihide Momozawa and Masashi Fujita and Kenneth Muir and Artitaya Lophatananon and Peggy Wan and {Le Marchand}, Loic and Wilkens, {Lynne R.} and Stevens, {Victoria L.} and Gapstur, {Susan M.} and Carter, {Brian D.} and Johanna Schleutker and Tammela, {Teuvo L.J.} and Csilla Sipeky and Anssi Auvinen and Giles, {Graham G.} and Southey, {Melissa C.} and MacInnis, {Robert J.} and Cezary Cybulski and Dominika Woko{\l}orczyk and Jan Lubi{\'n}ski and Neal, {David E.} and Donovan, {Jenny L.} and Hamdy, {Freddie C.} and Martin, {Richard M.} and Nordestgaard, {B{\o}rge G.} and Nielsen, {Sune F.} and Maren Weischer and Bojesen, {Stig E.} and R{\o}der, {Martin Andreas} and Peter Iversen and Jyotsna Batra and Suzanne Chambers and Leire Moya and Lisa Horvath and Clements, {Judith A.} and Wayne Tilley and Risbridger, {Gail P.} and Henrik Gronberg and Markus Aly and Robert Szulkin and Martin Eklund and Tobias Nordstr{\"o}m and Nora Pashayan and Dunning, {Alison M.} and Maya Ghoussaini and Travis, {Ruth C.} and Key, {Tim J.} and Elio Riboli and Park, {Jong Y.} and Sellers, {Thomas A.} and Lin, {Hui Yi} and Demetrius Albanes and Weinstein, {Stephanie J.} and Mucci, {Lorelei A.} and Edward Giovannucci and Sara Lindstrom and Peter Kraft and Hunter, {David J.} and Penney, {Kathryn L.} and Constance Turman and Tangen, {Catherine M.} and Goodman, {Phyllis J.} and Thompson, {Ian M.} and Hamilton, {Robert J.} and Fleshner, {Neil E.} and Antonio Finelli and Parent, {Marie {\'E}lise} and Stanford, {Janet L.} and Ostrander, {Elaine A.} and Geybels, {Milan S.} and Stella Koutros and Freeman, {Laura E.Beane} and Meir Stampfer and Alicja Wolk and Niclas H{\aa}kansson and Andriole, {Gerald L.} and Hoover, {Robert N.} and Machiela, {Mitchell J.} and S{\o}rensen, {Karina Dalsgaard} and Michael Borre and Blot, {William J.} and Wei Zheng and Yeboah, {Edward D.} and Mensah, {James E.} and Lu, {Yong Jie}",
year = "2021",
month = jan,
day = "1",
doi = "10.1038/s41588-020-00748-0",
language = "English",
volume = "53",
pages = "65--75",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "1",
}
