Thyroxine suppression therapy for benign, non-functioning solitary thyroid nodules: A quality-effects meta-analysis

Altayyeb Yousef, Justin Clark, Suhail A R Doi

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Levothyroxine (LT4) suppressive therapy for solitary thyroid nodules is not popularly advocated presently because its clinical efficacy and safety are currently considered controversial. This meta-analysis aims to address efficacy issues by using rigorous methods to arrive at a pooled estimate. On the basis of the analysis, it is estimated that LT4 therapy is clearly associated with up to a two-fold increase in the chance of nodule reduction. This translates to a number needed to treat (NNT) of 6 or a 50% decrease in the risk of cancer given nodule reduction. Keeping this definition of efficacy in mind and a low incidence of adverse events with low level LT4 suppression, such an intervention might be appropriate in patients selected on the basis of a low risk for adverse effects.

Original languageEnglish
Pages (from-to)150-158
Number of pages9
JournalClinical Medicine and Research
Volume8
Issue number3-4
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

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Thyroid Nodule
Thyroxine
Meta-Analysis
Numbers Needed To Treat
Safety
Incidence
Therapeutics
Neoplasms

Cite this

Yousef, Altayyeb ; Clark, Justin ; Doi, Suhail A R. / Thyroxine suppression therapy for benign, non-functioning solitary thyroid nodules : A quality-effects meta-analysis. In: Clinical Medicine and Research. 2010 ; Vol. 8, No. 3-4. pp. 150-158.
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Thyroxine suppression therapy for benign, non-functioning solitary thyroid nodules : A quality-effects meta-analysis. / Yousef, Altayyeb; Clark, Justin; Doi, Suhail A R.

In: Clinical Medicine and Research, Vol. 8, No. 3-4, 12.2010, p. 150-158.

Research output: Contribution to journalArticleResearchpeer-review

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