Therapeutic comparison of thiol compounds in severe paracetamol poisoning

A. E. Solomon; J. D. Briggs; J. Knepil; D. A. Henry; J. F. Winchester; R. Birrell

doi:10.1177/000456327701400155

Therapeutic comparison of thiol compounds in severe paracetamol poisoning

A. E. Solomon, J. D. Briggs, J. Knepil, D. A. Henry, J. F. Winchester, R. Birrell

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Abstract

Twelve patients with toxic blood concentrations of paracetamol were treated with either cysteamine or amino-acid solution. None of the patients developed severe liver damage, although transient mild biochemical abnormalities developed in three. None of the patients treated with amino-acid solution had side effects due to therapy, whereas all those treated with cysteamine did. It is recommended that amino-acid solutions be used as a temporary measure in patients suspected of massive paracetamol overdose while awaiting estimation of blood paracetamol concentration.

Original language	English
Pages (from-to)	200-202
Number of pages	3
Journal	Annals of Clinical Biochemistry
Volume	14
Issue number	4
DOIs	https://doi.org/10.1177/000456327701400155
Publication status	Published - 1977
Externally published	Yes

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title = "Therapeutic comparison of thiol compounds in severe paracetamol poisoning",

abstract = "Twelve patients with toxic blood concentrations of paracetamol were treated with either cysteamine or amino-acid solution. None of the patients developed severe liver damage, although transient mild biochemical abnormalities developed in three. None of the patients treated with amino-acid solution had side effects due to therapy, whereas all those treated with cysteamine did. It is recommended that amino-acid solutions be used as a temporary measure in patients suspected of massive paracetamol overdose while awaiting estimation of blood paracetamol concentration.",

author = "Solomon, {A. E.} and Briggs, {J. D.} and J. Knepil and Henry, {D. A.} and Winchester, {J. F.} and R. Birrell",

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AU - Briggs, J. D.

AU - Knepil, J.

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AU - Winchester, J. F.

AU - Birrell, R.

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AB - Twelve patients with toxic blood concentrations of paracetamol were treated with either cysteamine or amino-acid solution. None of the patients developed severe liver damage, although transient mild biochemical abnormalities developed in three. None of the patients treated with amino-acid solution had side effects due to therapy, whereas all those treated with cysteamine did. It is recommended that amino-acid solutions be used as a temporary measure in patients suspected of massive paracetamol overdose while awaiting estimation of blood paracetamol concentration.

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ER -

Therapeutic comparison of thiol compounds in severe paracetamol poisoning

Abstract

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