Therapeutic comparison of thiol compounds in severe paracetamol poisoning

A. E. Solomon, J. D. Briggs, J. Knepil, D. A. Henry, J. F. Winchester, R. Birrell

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)


Twelve patients with toxic blood concentrations of paracetamol were treated with either cysteamine or amino-acid solution. None of the patients developed severe liver damage, although transient mild biochemical abnormalities developed in three. None of the patients treated with amino-acid solution had side effects due to therapy, whereas all those treated with cysteamine did. It is recommended that amino-acid solutions be used as a temporary measure in patients suspected of massive paracetamol overdose while awaiting estimation of blood paracetamol concentration.
Original languageEnglish
Pages (from-to)200-202
Number of pages3
JournalAnnals of Clinical Biochemistry
Issue number4
Publication statusPublished - 1977
Externally publishedYes


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