The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients

Christopher F. Sharpley, David R. H. Christie, Vicki Bitsika, Linda L. Agnew, Nicholas M. Andronicos, Mary E. McMillan, Timothy M. Richards

Research output: Contribution to journalEditorialResearchpeer-review

1 Citation (Scopus)

Abstract

Methods A sample of saliva was collected from 107 Prostate Cancer (PCa) patients 45 min after waking in the morning (i.e., at the apex of the diurnal variation). Patients also completed the PHQ9 9, a brief and validated self-report scale for measuring Major Depressive Disorder, on the same day. Background data regarding cancer status and treatment were also collected. Cortisol assay procedures were commensurate with those in the current and past literature.Results Patients were aged between 52 and 82 years (M = 68.4yr, SD = 6.2yr), had received their diagnosis an average of 19.7 months prior (range = 2 to 83mo). Most (85.7%) lived with their wife or partner, with 8.8% divorced, 2.2% widowed and 3.3% never married. Most (70.3%) were experiencing their first bout of PCa, with 28.6% suffering from recurring PCa and 1.1% in remission. Past treatments included radiation therapy (0.9%), surgery (41.8%), hormone therapy (14.5%), combinations of these treatments (2.7%), no treatment (1.8%), and watchful waiting (38.3%). Current treatments were: radiation therapy (73.2%) awaiting surgery (0.8%), hormone therapy (0.0%), combinations of these (23.5%), no treatment (0.8%), and watchful waiting (1.7%). PHQ9 scores ranged from 10 to 23 (M = 12.6, SD = 2.6). The authors of the PHQ9 described scores of 10 to 14 as “moderate, requiring a treatment plan”, 15 -19 as “moderately severe, requiring immediate” treatment, and 20-27 as “severe”, also requiring immediate treatment.
Original languageEnglish
Pages (from-to)1400-1402
Number of pages3
JournalPsycho-Oncology
Volume26
Issue number9
DOIs
Publication statusPublished - Sep 2017

Cite this

Sharpley, C. F., Christie, D. R. H., Bitsika, V., Agnew, L. L., Andronicos, N. M., McMillan, M. E., & Richards, T. M. (2017). The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients. Psycho-Oncology, 26(9), 1400-1402. https://doi.org/10.1002/pon.4327
Sharpley, Christopher F. ; Christie, David R. H. ; Bitsika, Vicki ; Agnew, Linda L. ; Andronicos, Nicholas M. ; McMillan, Mary E. ; Richards, Timothy M. / The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients. In: Psycho-Oncology. 2017 ; Vol. 26, No. 9. pp. 1400-1402.
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title = "The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients",
abstract = "Methods A sample of saliva was collected from 107 Prostate Cancer (PCa) patients 45 min after waking in the morning (i.e., at the apex of the diurnal variation). Patients also completed the PHQ9 9, a brief and validated self-report scale for measuring Major Depressive Disorder, on the same day. Background data regarding cancer status and treatment were also collected. Cortisol assay procedures were commensurate with those in the current and past literature.Results Patients were aged between 52 and 82 years (M = 68.4yr, SD = 6.2yr), had received their diagnosis an average of 19.7 months prior (range = 2 to 83mo). Most (85.7{\%}) lived with their wife or partner, with 8.8{\%} divorced, 2.2{\%} widowed and 3.3{\%} never married. Most (70.3{\%}) were experiencing their first bout of PCa, with 28.6{\%} suffering from recurring PCa and 1.1{\%} in remission. Past treatments included radiation therapy (0.9{\%}), surgery (41.8{\%}), hormone therapy (14.5{\%}), combinations of these treatments (2.7{\%}), no treatment (1.8{\%}), and watchful waiting (38.3{\%}). Current treatments were: radiation therapy (73.2{\%}) awaiting surgery (0.8{\%}), hormone therapy (0.0{\%}), combinations of these (23.5{\%}), no treatment (0.8{\%}), and watchful waiting (1.7{\%}). PHQ9 scores ranged from 10 to 23 (M = 12.6, SD = 2.6). The authors of the PHQ9 described scores of 10 to 14 as “moderate, requiring a treatment plan”, 15 -19 as “moderately severe, requiring immediate” treatment, and 20-27 as “severe”, also requiring immediate treatment.",
author = "Sharpley, {Christopher F.} and Christie, {David R. H.} and Vicki Bitsika and Agnew, {Linda L.} and Andronicos, {Nicholas M.} and McMillan, {Mary E.} and Richards, {Timothy M.}",
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Sharpley, CF, Christie, DRH, Bitsika, V, Agnew, LL, Andronicos, NM, McMillan, ME & Richards, TM 2017, 'The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients' Psycho-Oncology, vol. 26, no. 9, pp. 1400-1402. https://doi.org/10.1002/pon.4327

The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients. / Sharpley, Christopher F.; Christie, David R. H.; Bitsika, Vicki; Agnew, Linda L.; Andronicos, Nicholas M.; McMillan, Mary E.; Richards, Timothy M.

In: Psycho-Oncology, Vol. 26, No. 9, 09.2017, p. 1400-1402.

Research output: Contribution to journalEditorialResearchpeer-review

TY - JOUR

T1 - The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients

AU - Sharpley, Christopher F.

AU - Christie, David R. H.

AU - Bitsika, Vicki

AU - Agnew, Linda L.

AU - Andronicos, Nicholas M.

AU - McMillan, Mary E.

AU - Richards, Timothy M.

PY - 2017/9

Y1 - 2017/9

N2 - Methods A sample of saliva was collected from 107 Prostate Cancer (PCa) patients 45 min after waking in the morning (i.e., at the apex of the diurnal variation). Patients also completed the PHQ9 9, a brief and validated self-report scale for measuring Major Depressive Disorder, on the same day. Background data regarding cancer status and treatment were also collected. Cortisol assay procedures were commensurate with those in the current and past literature.Results Patients were aged between 52 and 82 years (M = 68.4yr, SD = 6.2yr), had received their diagnosis an average of 19.7 months prior (range = 2 to 83mo). Most (85.7%) lived with their wife or partner, with 8.8% divorced, 2.2% widowed and 3.3% never married. Most (70.3%) were experiencing their first bout of PCa, with 28.6% suffering from recurring PCa and 1.1% in remission. Past treatments included radiation therapy (0.9%), surgery (41.8%), hormone therapy (14.5%), combinations of these treatments (2.7%), no treatment (1.8%), and watchful waiting (38.3%). Current treatments were: radiation therapy (73.2%) awaiting surgery (0.8%), hormone therapy (0.0%), combinations of these (23.5%), no treatment (0.8%), and watchful waiting (1.7%). PHQ9 scores ranged from 10 to 23 (M = 12.6, SD = 2.6). The authors of the PHQ9 described scores of 10 to 14 as “moderate, requiring a treatment plan”, 15 -19 as “moderately severe, requiring immediate” treatment, and 20-27 as “severe”, also requiring immediate treatment.

AB - Methods A sample of saliva was collected from 107 Prostate Cancer (PCa) patients 45 min after waking in the morning (i.e., at the apex of the diurnal variation). Patients also completed the PHQ9 9, a brief and validated self-report scale for measuring Major Depressive Disorder, on the same day. Background data regarding cancer status and treatment were also collected. Cortisol assay procedures were commensurate with those in the current and past literature.Results Patients were aged between 52 and 82 years (M = 68.4yr, SD = 6.2yr), had received their diagnosis an average of 19.7 months prior (range = 2 to 83mo). Most (85.7%) lived with their wife or partner, with 8.8% divorced, 2.2% widowed and 3.3% never married. Most (70.3%) were experiencing their first bout of PCa, with 28.6% suffering from recurring PCa and 1.1% in remission. Past treatments included radiation therapy (0.9%), surgery (41.8%), hormone therapy (14.5%), combinations of these treatments (2.7%), no treatment (1.8%), and watchful waiting (38.3%). Current treatments were: radiation therapy (73.2%) awaiting surgery (0.8%), hormone therapy (0.0%), combinations of these (23.5%), no treatment (0.8%), and watchful waiting (1.7%). PHQ9 scores ranged from 10 to 23 (M = 12.6, SD = 2.6). The authors of the PHQ9 described scores of 10 to 14 as “moderate, requiring a treatment plan”, 15 -19 as “moderately severe, requiring immediate” treatment, and 20-27 as “severe”, also requiring immediate treatment.

U2 - 10.1002/pon.4327

DO - 10.1002/pon.4327

M3 - Editorial

VL - 26

SP - 1400

EP - 1402

JO - Psycho-Oncology

JF - Psycho-Oncology

SN - 1057-9249

IS - 9

ER -

Sharpley CF, Christie DRH, Bitsika V, Agnew LL, Andronicos NM, McMillan ME et al. The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients. Psycho-Oncology. 2017 Sep;26(9):1400-1402. https://doi.org/10.1002/pon.4327