The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature

Guy C Wilson, Yorgi Mavros, Lotti Tajouri, Maria Fiatarone Singh

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BACKGROUND:: Variations in genotype may contribute to heterogeneity in functional adaptations to exercise.

METHODS:: A systematic search of 8 databases was conducted, and 9696 citations were screened.

RESULTS:: Eight citations from 7 studies measuring 10 single nucleotide polymorphisms (SNPs) and 9 different functional performance test outcomes were included in the review. There was one observational study of physical activity and 6 experimental studies of aerobic or resistance training. The ACE (D) allele, ACTN3 (RR) genotype, UCP2 (GG) genotype, IL6-174 (GG), TNFα-308 (GG) and IL10-1082 (GG) genotype all predicted significantly superior adaptations in at least one functional outcome in older men and women after prescribed exercise or in those with higher levels of physical activity.

CONCLUSION:: There is a small amount of evidence that older adults may have better functional outcomes after exercise/physical activity if they have specific alleles related to musculoskeletal function or inflammation. However, more robust trials are needed.

Original languageEnglish
Pages (from-to)1-66
Number of pages66
JournalJournal of Aging and Physical Activity
DOIs
Publication statusE-pub ahead of print - 24 Jan 2019

Fingerprint

Teaching
Exercise
Genotype
Alleles
Resistance Training
Interleukin-10
Observational Studies
Single Nucleotide Polymorphism
Interleukin-6
Databases
Inflammation

Cite this

@article{e04b977af61e4755bb77ea8ed5e71622,
title = "The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature",
abstract = "BACKGROUND:: Variations in genotype may contribute to heterogeneity in functional adaptations to exercise.METHODS:: A systematic search of 8 databases was conducted, and 9696 citations were screened.RESULTS:: Eight citations from 7 studies measuring 10 single nucleotide polymorphisms (SNPs) and 9 different functional performance test outcomes were included in the review. There was one observational study of physical activity and 6 experimental studies of aerobic or resistance training. The ACE (D) allele, ACTN3 (RR) genotype, UCP2 (GG) genotype, IL6-174 (GG), TNFα-308 (GG) and IL10-1082 (GG) genotype all predicted significantly superior adaptations in at least one functional outcome in older men and women after prescribed exercise or in those with higher levels of physical activity.CONCLUSION:: There is a small amount of evidence that older adults may have better functional outcomes after exercise/physical activity if they have specific alleles related to musculoskeletal function or inflammation. However, more robust trials are needed.",
author = "Wilson, {Guy C} and Yorgi Mavros and Lotti Tajouri and Singh, {Maria Fiatarone}",
year = "2019",
month = "1",
day = "24",
doi = "10.1123/japa.2018-0155",
language = "English",
pages = "1--66",
journal = "Journal of Aging and Physical Activity",
issn = "1063-8652",
publisher = "HUMAN KINETICS PUBL INC",

}

The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity : A Systematic Review of the Literature. / Wilson, Guy C; Mavros, Yorgi; Tajouri, Lotti; Singh, Maria Fiatarone.

In: Journal of Aging and Physical Activity, 24.01.2019, p. 1-66.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity

T2 - A Systematic Review of the Literature

AU - Wilson, Guy C

AU - Mavros, Yorgi

AU - Tajouri, Lotti

AU - Singh, Maria Fiatarone

PY - 2019/1/24

Y1 - 2019/1/24

N2 - BACKGROUND:: Variations in genotype may contribute to heterogeneity in functional adaptations to exercise.METHODS:: A systematic search of 8 databases was conducted, and 9696 citations were screened.RESULTS:: Eight citations from 7 studies measuring 10 single nucleotide polymorphisms (SNPs) and 9 different functional performance test outcomes were included in the review. There was one observational study of physical activity and 6 experimental studies of aerobic or resistance training. The ACE (D) allele, ACTN3 (RR) genotype, UCP2 (GG) genotype, IL6-174 (GG), TNFα-308 (GG) and IL10-1082 (GG) genotype all predicted significantly superior adaptations in at least one functional outcome in older men and women after prescribed exercise or in those with higher levels of physical activity.CONCLUSION:: There is a small amount of evidence that older adults may have better functional outcomes after exercise/physical activity if they have specific alleles related to musculoskeletal function or inflammation. However, more robust trials are needed.

AB - BACKGROUND:: Variations in genotype may contribute to heterogeneity in functional adaptations to exercise.METHODS:: A systematic search of 8 databases was conducted, and 9696 citations were screened.RESULTS:: Eight citations from 7 studies measuring 10 single nucleotide polymorphisms (SNPs) and 9 different functional performance test outcomes were included in the review. There was one observational study of physical activity and 6 experimental studies of aerobic or resistance training. The ACE (D) allele, ACTN3 (RR) genotype, UCP2 (GG) genotype, IL6-174 (GG), TNFα-308 (GG) and IL10-1082 (GG) genotype all predicted significantly superior adaptations in at least one functional outcome in older men and women after prescribed exercise or in those with higher levels of physical activity.CONCLUSION:: There is a small amount of evidence that older adults may have better functional outcomes after exercise/physical activity if they have specific alleles related to musculoskeletal function or inflammation. However, more robust trials are needed.

U2 - 10.1123/japa.2018-0155

DO - 10.1123/japa.2018-0155

M3 - Article

SP - 1

EP - 66

JO - Journal of Aging and Physical Activity

JF - Journal of Aging and Physical Activity

SN - 1063-8652

ER -