The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature

Guy C Wilson, Yorgi Mavros, Lotti Tajouri, Maria Fiatarone Singh

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)


BACKGROUND:: Variations in genotype may contribute to heterogeneity in functional adaptations to exercise.

METHODS:: A systematic search of 8 databases was conducted, and 9696 citations were screened.

RESULTS:: Eight citations from 7 studies measuring 10 single nucleotide polymorphisms (SNPs) and 9 different functional performance test outcomes were included in the review. There was one observational study of physical activity and 6 experimental studies of aerobic or resistance training. The ACE (D) allele, ACTN3 (RR) genotype, UCP2 (GG) genotype, IL6-174 (GG), TNFα-308 (GG) and IL10-1082 (GG) genotype all predicted significantly superior adaptations in at least one functional outcome in older men and women after prescribed exercise or in those with higher levels of physical activity.

CONCLUSION:: There is a small amount of evidence that older adults may have better functional outcomes after exercise/physical activity if they have specific alleles related to musculoskeletal function or inflammation. However, more robust trials are needed.

Original languageEnglish
Pages (from-to)594-616
Number of pages23
JournalJournal of Aging and Physical Activity
Issue number4
Publication statusE-pub ahead of print - 24 Jan 2019


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