The role of dendritic cells in T cell activation

Keping Ni, H. C. O'Neill

Research output: Contribution to journalReview articleResearchpeer-review

84 Citations (Scopus)

Abstract

Dendritic cells (DC) are distinguishable from other antigen-presenting cells by their potent antigen-presenting capacity. They are not only efficient at presenting peptide antigen but can also process and present soluble protein antigens to antigen-specific T cells and cloned T cell lines. They are very strong stimulators of both allogeneic and syngeneic mixed lymphocyte reactions and have a unique capacity to stimulate naive T cells. The potent functional capacity of DC is related to a high-level expression of major histocompatibility complex class I/II molecules and constitutive expression of costimulatory molecules, such as CD80/CD86, as well as heat stable antigen, CD40 and the leucocyte function antigen (LFA) family of adhesion molecules. Recent studies have shown that DC are also involved in regulation of the immune response via induction of both central and peripheral tolerance.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalImmunology and Cell Biology
Volume75
Issue number3
DOIs
Publication statusPublished - 1997
Externally publishedYes

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T-cells
Dendritic Cells
Chemical activation
T-Lymphocytes
Antigens
CD40 Antigens
Central Tolerance
Molecules
Peripheral Tolerance
Mixed Lymphocyte Culture Test
Antigen-Presenting Cells
HLA Antigens
Major Histocompatibility Complex
Lymphocytes
Hot Temperature
Cell Line
Adhesion
Peptides
Proteins

Cite this

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The role of dendritic cells in T cell activation. / Ni, Keping; O'Neill, H. C.

In: Immunology and Cell Biology, Vol. 75, No. 3, 1997, p. 223-230.

Research output: Contribution to journalReview articleResearchpeer-review

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