The role of adenosine-related genes variants in susceptibility to essential hypertension

Kirsty Wright; Lotti Tajouri; Rod A. Lea; Micky Ovcaric; Stephanie Heux; Fabien Morin; Wallid Bey; John P. Headrick; Lyn R. Griffiths

doi:10.1097/01.hjh.0000133723.16947.6d

The role of adenosine-related genes variants in susceptibility to essential hypertension

Kirsty Wright, Lotti Tajouri, Rod A. Lea, Micky Ovcaric, Stephanie Heux, Fabien Morin, Wallid Bey, John P. Headrick, Lyn R. Griffiths^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

Objective: To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH). Design: Case-control association study investigating gene variants for the ADORA1, ADORA2a and ADA genes. Participants: The study used a cohort of 249 unrelated hypertensive individuals who were diagnosed with hypertension, and an age, sex and ethnically matched group of 249 normotensive controls. Results: The association analysis indicated that both allele and genotype frequencies did not differ significantly between the case and control groups (P > 0.05) for any of the markers tested. Conclusion: The adenosine-related gene variants do not appear to alter susceptibility to the disease in this group of essential hypertensives. However, involvement of these genes and the adenosine system cannot be conclusively excluded from essential hypertension pathogenesis as other gene variants may still be involved.

Original language	English
Pages (from-to)	1519-1522
Number of pages	4
Journal	Journal of Hypertension
Volume	22
Issue number	8
DOIs	https://doi.org/10.1097/01.hjh.0000133723.16947.6d
Publication status	Published - Aug 2004
Externally published	Yes

Access to Document

10.1097/01.hjh.0000133723.16947.6d

Cite this

@article{1e73276a581743a8bbe288588abb6fdc,

title = "The role of adenosine-related genes variants in susceptibility to essential hypertension",

abstract = "Objective: To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH). Design: Case-control association study investigating gene variants for the ADORA1, ADORA2a and ADA genes. Participants: The study used a cohort of 249 unrelated hypertensive individuals who were diagnosed with hypertension, and an age, sex and ethnically matched group of 249 normotensive controls. Results: The association analysis indicated that both allele and genotype frequencies did not differ significantly between the case and control groups (P > 0.05) for any of the markers tested. Conclusion: The adenosine-related gene variants do not appear to alter susceptibility to the disease in this group of essential hypertensives. However, involvement of these genes and the adenosine system cannot be conclusively excluded from essential hypertension pathogenesis as other gene variants may still be involved.",

author = "Kirsty Wright and Lotti Tajouri and Lea, {Rod A.} and Micky Ovcaric and Stephanie Heux and Fabien Morin and Wallid Bey and Headrick, {John P.} and Griffiths, {Lyn R.}",

year = "2004",

month = aug,

doi = "10.1097/01.hjh.0000133723.16947.6d",

language = "English",

volume = "22",

pages = "1519--1522",

journal = "Journal of Hypertension",

issn = "0263-6352",

publisher = "Lippincott Williams & Wilkins",

number = "8",

}

TY - JOUR

T1 - The role of adenosine-related genes variants in susceptibility to essential hypertension

AU - Wright, Kirsty

AU - Tajouri, Lotti

AU - Lea, Rod A.

AU - Ovcaric, Micky

AU - Heux, Stephanie

AU - Morin, Fabien

AU - Bey, Wallid

AU - Headrick, John P.

AU - Griffiths, Lyn R.

PY - 2004/8

Y1 - 2004/8

N2 - Objective: To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH). Design: Case-control association study investigating gene variants for the ADORA1, ADORA2a and ADA genes. Participants: The study used a cohort of 249 unrelated hypertensive individuals who were diagnosed with hypertension, and an age, sex and ethnically matched group of 249 normotensive controls. Results: The association analysis indicated that both allele and genotype frequencies did not differ significantly between the case and control groups (P > 0.05) for any of the markers tested. Conclusion: The adenosine-related gene variants do not appear to alter susceptibility to the disease in this group of essential hypertensives. However, involvement of these genes and the adenosine system cannot be conclusively excluded from essential hypertension pathogenesis as other gene variants may still be involved.

AB - Objective: To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH). Design: Case-control association study investigating gene variants for the ADORA1, ADORA2a and ADA genes. Participants: The study used a cohort of 249 unrelated hypertensive individuals who were diagnosed with hypertension, and an age, sex and ethnically matched group of 249 normotensive controls. Results: The association analysis indicated that both allele and genotype frequencies did not differ significantly between the case and control groups (P > 0.05) for any of the markers tested. Conclusion: The adenosine-related gene variants do not appear to alter susceptibility to the disease in this group of essential hypertensives. However, involvement of these genes and the adenosine system cannot be conclusively excluded from essential hypertension pathogenesis as other gene variants may still be involved.

UR - http://www.scopus.com/inward/record.url?scp=3843076321&partnerID=8YFLogxK

U2 - 10.1097/01.hjh.0000133723.16947.6d

DO - 10.1097/01.hjh.0000133723.16947.6d

M3 - Article

C2 - 15257174

AN - SCOPUS:3843076321

SN - 0263-6352

VL - 22

SP - 1519

EP - 1522

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 8

ER -

The role of adenosine-related genes variants in susceptibility to essential hypertension

Abstract

Access to Document

Other files and links

Fingerprint

Cite this