The relationship between in vivo emptying of the gallbladder, biliary pain, and in vitro contractility of the gallbladder in patients with gallstones

Is biliary colic muscular in origin?

H. Wegstapel, N. C. Bird*, R. Chess-Williams, A. G. Johnson

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Background: This study sought to determine whether there is a positive correlation between gallbladder emptying, biliary pain, and in vitro contractility. Methods: Ultrasound measurements were carried out on 25 gallstone patients. The response of gallbladder strips to 1.75*10-11 to 5.25*10-7 M cholecystokinin-8 was recorded. In a second study 23 patients filled in pain questionnaires, and in vitro studies were again carried out. Results: Of five patients with no gallbladder emptying, four had in vitro contraction. Overall, a significant, positive linear correlation was found (P < 0.0001). In the second study in vitro contractility showed a positive linear correlation with pain. Conclusion: Gallbladder emptying correlates with contractility. However, since most 'non-contractors' can contract, we suggest the term 'non-emptying' or 'emptying' to describe gallbladder dynamics. The positive correlation between pain and contractility suggests that biliary pain has a muscular component.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume34
Issue number4
DOIs
Publication statusPublished - 27 May 1999
Externally publishedYes

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Gallbladder Emptying
Colic
Gallstones
Gallbladder
Pain
Contracts
In Vitro Techniques

Cite this

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title = "The relationship between in vivo emptying of the gallbladder, biliary pain, and in vitro contractility of the gallbladder in patients with gallstones: Is biliary colic muscular in origin?",
abstract = "Background: This study sought to determine whether there is a positive correlation between gallbladder emptying, biliary pain, and in vitro contractility. Methods: Ultrasound measurements were carried out on 25 gallstone patients. The response of gallbladder strips to 1.75*10-11 to 5.25*10-7 M cholecystokinin-8 was recorded. In a second study 23 patients filled in pain questionnaires, and in vitro studies were again carried out. Results: Of five patients with no gallbladder emptying, four had in vitro contraction. Overall, a significant, positive linear correlation was found (P < 0.0001). In the second study in vitro contractility showed a positive linear correlation with pain. Conclusion: Gallbladder emptying correlates with contractility. However, since most 'non-contractors' can contract, we suggest the term 'non-emptying' or 'emptying' to describe gallbladder dynamics. The positive correlation between pain and contractility suggests that biliary pain has a muscular component.",
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The relationship between in vivo emptying of the gallbladder, biliary pain, and in vitro contractility of the gallbladder in patients with gallstones : Is biliary colic muscular in origin? / Wegstapel, H.; Bird, N. C.; Chess-Williams, R.; Johnson, A. G.

In: Scandinavian Journal of Gastroenterology, Vol. 34, No. 4, 27.05.1999, p. 421-425.

Research output: Contribution to journalArticleResearchpeer-review

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T2 - Is biliary colic muscular in origin?

AU - Wegstapel, H.

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AU - Chess-Williams, R.

AU - Johnson, A. G.

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N2 - Background: This study sought to determine whether there is a positive correlation between gallbladder emptying, biliary pain, and in vitro contractility. Methods: Ultrasound measurements were carried out on 25 gallstone patients. The response of gallbladder strips to 1.75*10-11 to 5.25*10-7 M cholecystokinin-8 was recorded. In a second study 23 patients filled in pain questionnaires, and in vitro studies were again carried out. Results: Of five patients with no gallbladder emptying, four had in vitro contraction. Overall, a significant, positive linear correlation was found (P < 0.0001). In the second study in vitro contractility showed a positive linear correlation with pain. Conclusion: Gallbladder emptying correlates with contractility. However, since most 'non-contractors' can contract, we suggest the term 'non-emptying' or 'emptying' to describe gallbladder dynamics. The positive correlation between pain and contractility suggests that biliary pain has a muscular component.

AB - Background: This study sought to determine whether there is a positive correlation between gallbladder emptying, biliary pain, and in vitro contractility. Methods: Ultrasound measurements were carried out on 25 gallstone patients. The response of gallbladder strips to 1.75*10-11 to 5.25*10-7 M cholecystokinin-8 was recorded. In a second study 23 patients filled in pain questionnaires, and in vitro studies were again carried out. Results: Of five patients with no gallbladder emptying, four had in vitro contraction. Overall, a significant, positive linear correlation was found (P < 0.0001). In the second study in vitro contractility showed a positive linear correlation with pain. Conclusion: Gallbladder emptying correlates with contractility. However, since most 'non-contractors' can contract, we suggest the term 'non-emptying' or 'emptying' to describe gallbladder dynamics. The positive correlation between pain and contractility suggests that biliary pain has a muscular component.

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