The relationship between in vivo emptying of the gallbladder, biliary pain, and in vitro contractility of the gallbladder in patients with gallstones: Is biliary colic muscular in origin?

H. Wegstapel, N. C. Bird, R. Chess-Williams, A. G. Johnson

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Background: This study sought to determine whether there is a positive correlation between gallbladder emptying, biliary pain, and in vitro contractility. Methods: Ultrasound measurements were carried out on 25 gallstone patients. The response of gallbladder strips to 1.75*10-11 to 5.25*10-7 M cholecystokinin-8 was recorded. In a second study 23 patients filled in pain questionnaires, and in vitro studies were again carried out. Results: Of five patients with no gallbladder emptying, four had in vitro contraction. Overall, a significant, positive linear correlation was found (P < 0.0001). In the second study in vitro contractility showed a positive linear correlation with pain. Conclusion: Gallbladder emptying correlates with contractility. However, since most 'non-contractors' can contract, we suggest the term 'non-emptying' or 'emptying' to describe gallbladder dynamics. The positive correlation between pain and contractility suggests that biliary pain has a muscular component.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume34
Issue number4
DOIs
Publication statusPublished - 27 May 1999
Externally publishedYes

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Gallbladder Emptying
Colic
Gallstones
Gallbladder
Pain
Contracts
In Vitro Techniques

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title = "The relationship between in vivo emptying of the gallbladder, biliary pain, and in vitro contractility of the gallbladder in patients with gallstones: Is biliary colic muscular in origin?",
abstract = "Background: This study sought to determine whether there is a positive correlation between gallbladder emptying, biliary pain, and in vitro contractility. Methods: Ultrasound measurements were carried out on 25 gallstone patients. The response of gallbladder strips to 1.75*10-11 to 5.25*10-7 M cholecystokinin-8 was recorded. In a second study 23 patients filled in pain questionnaires, and in vitro studies were again carried out. Results: Of five patients with no gallbladder emptying, four had in vitro contraction. Overall, a significant, positive linear correlation was found (P < 0.0001). In the second study in vitro contractility showed a positive linear correlation with pain. Conclusion: Gallbladder emptying correlates with contractility. However, since most 'non-contractors' can contract, we suggest the term 'non-emptying' or 'emptying' to describe gallbladder dynamics. The positive correlation between pain and contractility suggests that biliary pain has a muscular component.",
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The relationship between in vivo emptying of the gallbladder, biliary pain, and in vitro contractility of the gallbladder in patients with gallstones : Is biliary colic muscular in origin? / Wegstapel, H.; Bird, N. C.; Chess-Williams, R.; Johnson, A. G.

In: Scandinavian Journal of Gastroenterology, Vol. 34, No. 4, 27.05.1999, p. 421-425.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Chess-Williams, R.

AU - Johnson, A. G.

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AB - Background: This study sought to determine whether there is a positive correlation between gallbladder emptying, biliary pain, and in vitro contractility. Methods: Ultrasound measurements were carried out on 25 gallstone patients. The response of gallbladder strips to 1.75*10-11 to 5.25*10-7 M cholecystokinin-8 was recorded. In a second study 23 patients filled in pain questionnaires, and in vitro studies were again carried out. Results: Of five patients with no gallbladder emptying, four had in vitro contraction. Overall, a significant, positive linear correlation was found (P < 0.0001). In the second study in vitro contractility showed a positive linear correlation with pain. Conclusion: Gallbladder emptying correlates with contractility. However, since most 'non-contractors' can contract, we suggest the term 'non-emptying' or 'emptying' to describe gallbladder dynamics. The positive correlation between pain and contractility suggests that biliary pain has a muscular component.

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