TY - JOUR
T1 - The potential association between PARP14 and SARS-CoV-2 infection (COVID-19)
AU - Tauber, Amanda L
AU - Schweiker, Stephanie S
AU - Levonis, Stephan M
PY - 2021/3
Y1 - 2021/3
N2 - Understanding the potential association between the poly (ADP-ribose) polymerase member 14 (PARP14) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may aid in understanding the host immunopathological response to the virus. PARP14 has an emerging role in viral infections, and this article considers its potential mechanisms for action in either a pro- or anti-viral manner. It is evident that more experimental work is required; however, PARP14 appears vital in controlling the interferon response to the SARS-CoV-2 infection and has potential roles in balancing the proinflammatory cytokines of the cytokine storm. Furthermore, the SARS-CoV-2 macrodomain can prevent the PARP14-mediated antiviral response, suggesting a more complex relationship between PARP14 activity and SARS-CoV-2 infections.
AB - Understanding the potential association between the poly (ADP-ribose) polymerase member 14 (PARP14) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may aid in understanding the host immunopathological response to the virus. PARP14 has an emerging role in viral infections, and this article considers its potential mechanisms for action in either a pro- or anti-viral manner. It is evident that more experimental work is required; however, PARP14 appears vital in controlling the interferon response to the SARS-CoV-2 infection and has potential roles in balancing the proinflammatory cytokines of the cytokine storm. Furthermore, the SARS-CoV-2 macrodomain can prevent the PARP14-mediated antiviral response, suggesting a more complex relationship between PARP14 activity and SARS-CoV-2 infections.
UR - http://www.scopus.com/inward/record.url?scp=85102589353&partnerID=8YFLogxK
U2 - 10.4155/fmc-2020-0226
DO - 10.4155/fmc-2020-0226
M3 - Article
C2 - 33467912
VL - 13
SP - 587
EP - 592
JO - Future Medicinal Chemistry
JF - Future Medicinal Chemistry
SN - 1756-8927
IS - 6
ER -