The potential association between PARP14 and SARS-CoV-2 infection (COVID-19)

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Understanding the potential association between the poly (ADP-ribose) polymerase member 14 (PARP14) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may aid in understanding the host immunopathological response to the virus. PARP14 has an emerging role in viral infections, and this article considers its potential mechanisms for action in either a pro- or anti-viral manner. It is evident that more experimental work is required; however, PARP14 appears vital in controlling the interferon response to the SARS-CoV-2 infection and has potential roles in balancing the proinflammatory cytokines of the cytokine storm. Furthermore, the SARS-CoV-2 macrodomain can prevent the PARP14-mediated antiviral response, suggesting a more complex relationship between PARP14 activity and SARS-CoV-2 infections.

Original languageEnglish
Pages (from-to)587-592
Number of pages6
JournalFuture Medicinal Chemistry
Volume13
Issue number6
Early online date20 Jan 2021
DOIs
Publication statusPublished - Mar 2021

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