The lineage relationship of dendritic cells with other haematopoietic cells

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12 Citations (Scopus)

Abstract

The lineage relationship of dendritic cells with other haematopoietic cells and within the broader class of dendritic cells is not well understood. Dendritic cells in different tissue sites and having slightly different characteristics all play a specialized role in maintaining self tolerance by the endocytosis and presentation of antigens within their environment. Recent evidence now suggests a possible lineage relationship between T cells and lymphoid dendritic cells and appears to conflict with the view that dendritic cells have a common origin with myeloid cells. One possibility is that dendritic cells mature in different tissue sites from bone marrow-derived precursors and develop region-specific characteristics which could reflect lineage differences.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalScandinavian Journal of Immunology
Volume39
Issue number6
DOIs
Publication statusPublished - Jun 1994
Externally publishedYes

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Dendritic Cells
Self Tolerance
Antigen Presentation
Myeloid Cells
Endocytosis
Bone Marrow
Lymphocytes
T-Lymphocytes

Cite this

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title = "The lineage relationship of dendritic cells with other haematopoietic cells",
abstract = "The lineage relationship of dendritic cells with other haematopoietic cells and within the broader class of dendritic cells is not well understood. Dendritic cells in different tissue sites and having slightly different characteristics all play a specialized role in maintaining self tolerance by the endocytosis and presentation of antigens within their environment. Recent evidence now suggests a possible lineage relationship between T cells and lymphoid dendritic cells and appears to conflict with the view that dendritic cells have a common origin with myeloid cells. One possibility is that dendritic cells mature in different tissue sites from bone marrow-derived precursors and develop region-specific characteristics which could reflect lineage differences.",
author = "O'Neill, {Helen C}",
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pages = "513--516",
journal = "Scandinavian Journal of Immunology",
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publisher = "Wiley-Blackwell",
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}

The lineage relationship of dendritic cells with other haematopoietic cells. / O'Neill, Helen C.

In: Scandinavian Journal of Immunology, Vol. 39, No. 6, 06.1994, p. 513-516.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - The lineage relationship of dendritic cells with other haematopoietic cells

AU - O'Neill, Helen C

PY - 1994/6

Y1 - 1994/6

N2 - The lineage relationship of dendritic cells with other haematopoietic cells and within the broader class of dendritic cells is not well understood. Dendritic cells in different tissue sites and having slightly different characteristics all play a specialized role in maintaining self tolerance by the endocytosis and presentation of antigens within their environment. Recent evidence now suggests a possible lineage relationship between T cells and lymphoid dendritic cells and appears to conflict with the view that dendritic cells have a common origin with myeloid cells. One possibility is that dendritic cells mature in different tissue sites from bone marrow-derived precursors and develop region-specific characteristics which could reflect lineage differences.

AB - The lineage relationship of dendritic cells with other haematopoietic cells and within the broader class of dendritic cells is not well understood. Dendritic cells in different tissue sites and having slightly different characteristics all play a specialized role in maintaining self tolerance by the endocytosis and presentation of antigens within their environment. Recent evidence now suggests a possible lineage relationship between T cells and lymphoid dendritic cells and appears to conflict with the view that dendritic cells have a common origin with myeloid cells. One possibility is that dendritic cells mature in different tissue sites from bone marrow-derived precursors and develop region-specific characteristics which could reflect lineage differences.

U2 - 10.1111/j.1365-3083.1994.tb03407.x

DO - 10.1111/j.1365-3083.1994.tb03407.x

M3 - Review article

VL - 39

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EP - 516

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 6

ER -