The kidney-gut axis: Implications for nutrition care

Megan Rossi, David W. Johnson, Katrina L. Campbell

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

There is increasing clinical evidence that patients with chronic kidney disease (CKD) have a distinctly dysbiotic intestinal bacterial community, termed the gut microbiota, which in turn drives a cascade of metabolic abnormalities, including uremic toxin production, inflammation, and immunosuppression, that ultimately promotes progressive kidney failure and cardiovascular disease. As the gut microbiota is intimately influenced by diet, the discovery of the kidney-gut axis has created new therapeutic opportunities for nutritional intervention. This review discusses the metabolic pathways linking dysbiotic gut microbiota with adverse health outcomes in patients with CKD, as well as novel therapeutic strategies for targeting these pathways involving dietary protein, fiber, prebiotics, probiotics, and synbiotics. These emerging nutritional interventions may ultimately lead to a paradigm shift in the conventional focus of dietary management in CKD.

Original languageEnglish
Pages (from-to)399-403
Number of pages5
JournalJournal of Renal Nutrition
Volume25
Issue number5
DOIs
Publication statusPublished - 1 Sep 2015

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Chronic Renal Insufficiency
Kidney
Synbiotics
Prebiotics
Dietary Proteins
Probiotics
Dietary Fiber
Kidney Diseases
Metabolic Networks and Pathways
Immunosuppression
Renal Insufficiency
Cardiovascular Diseases
Diet
Inflammation
Health
Therapeutics
Gastrointestinal Microbiome

Cite this

Rossi, Megan ; Johnson, David W. ; Campbell, Katrina L. / The kidney-gut axis : Implications for nutrition care. In: Journal of Renal Nutrition. 2015 ; Vol. 25, No. 5. pp. 399-403.
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The kidney-gut axis : Implications for nutrition care. / Rossi, Megan; Johnson, David W.; Campbell, Katrina L.

In: Journal of Renal Nutrition, Vol. 25, No. 5, 01.09.2015, p. 399-403.

Research output: Contribution to journalArticleResearchpeer-review

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