The In‐vitro Effects of Insulin and the Effects of Acute Fasting on Cardiac β‐Adrenoceptor Responses in the Short‐term Streptozotocin‐diabetic Rat

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Abstract

Abstract— This study demonstrates that in‐vitro incubation with insulin results in a reduction of the sensitivity of cardiac tissues from streptozotocin‐diabetic rats to isoprenaline. Following incubation with insulin, the sensitivity of left atria and papillary muscles from diabetic animals was not significantly different from those of control animals. Insulin incubation had no effect on the sensitivity of diabetic tissues to forskolin or on ventricular β‐adrenoceptor number. Reduction of blood glucose in the absence of insulin by fasting, did not affect the sensitivity of tissues from diabetic animals to isoprenaline. These results suggest that insulin itself can directly reduce β‐adrenoceptor sensitivity without altering receptor number. 1994 Royal Pharmaceutical Society of Great Britain

Original languageEnglish
Pages (from-to)326-331
Number of pages6
JournalJournal of Pharmacy and Pharmacology
Volume46
Issue number5
DOIs
Publication statusPublished - 1 Jan 1994
Externally publishedYes

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Adrenergic Receptors
Fasting
Insulin
Isoproterenol
Papillary Muscles
Colforsin
Heart Atria
Insulin Resistance
Blood Glucose

Cite this

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title = "The In‐vitro Effects of Insulin and the Effects of Acute Fasting on Cardiac β‐Adrenoceptor Responses in the Short‐term Streptozotocin‐diabetic Rat",
abstract = "Abstract— This study demonstrates that in‐vitro incubation with insulin results in a reduction of the sensitivity of cardiac tissues from streptozotocin‐diabetic rats to isoprenaline. Following incubation with insulin, the sensitivity of left atria and papillary muscles from diabetic animals was not significantly different from those of control animals. Insulin incubation had no effect on the sensitivity of diabetic tissues to forskolin or on ventricular β‐adrenoceptor number. Reduction of blood glucose in the absence of insulin by fasting, did not affect the sensitivity of tissues from diabetic animals to isoprenaline. These results suggest that insulin itself can directly reduce β‐adrenoceptor sensitivity without altering receptor number. 1994 Royal Pharmaceutical Society of Great Britain",
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AU - Chess-Williams, Russell

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N2 - Abstract— This study demonstrates that in‐vitro incubation with insulin results in a reduction of the sensitivity of cardiac tissues from streptozotocin‐diabetic rats to isoprenaline. Following incubation with insulin, the sensitivity of left atria and papillary muscles from diabetic animals was not significantly different from those of control animals. Insulin incubation had no effect on the sensitivity of diabetic tissues to forskolin or on ventricular β‐adrenoceptor number. Reduction of blood glucose in the absence of insulin by fasting, did not affect the sensitivity of tissues from diabetic animals to isoprenaline. These results suggest that insulin itself can directly reduce β‐adrenoceptor sensitivity without altering receptor number. 1994 Royal Pharmaceutical Society of Great Britain

AB - Abstract— This study demonstrates that in‐vitro incubation with insulin results in a reduction of the sensitivity of cardiac tissues from streptozotocin‐diabetic rats to isoprenaline. Following incubation with insulin, the sensitivity of left atria and papillary muscles from diabetic animals was not significantly different from those of control animals. Insulin incubation had no effect on the sensitivity of diabetic tissues to forskolin or on ventricular β‐adrenoceptor number. Reduction of blood glucose in the absence of insulin by fasting, did not affect the sensitivity of tissues from diabetic animals to isoprenaline. These results suggest that insulin itself can directly reduce β‐adrenoceptor sensitivity without altering receptor number. 1994 Royal Pharmaceutical Society of Great Britain

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