The influence of dopamine on semantic activation in Parkinson's disease: Evidence from a multipriming task

Anthony J. Angwin, David A. Copland, Helen J. Chenery, Bruce E. Murdoch, Peter A. Silburn

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Research has suggested that semantic processing deficits in Parkinson's disease (PD) are related to striatal dopamine deficiency. As an investigation of the influence of dopamine on semantic activation in PD, 7 participants with PD performed a lexical-decision task when on and off levodopa medication. Seven healthy controls matched to the participants with PD in terms of sex, age, and education also participated in the study. By use of a multipriming paradigm, whereby 2 prime words were presented prior to the target word, semantic priming effects were measured across stimulus onset asynchronies (SOAs) of 250 ms and 1,200 ms. The results revealed a similar pattern of priming across SOAs for the control group and the PD participants on medication. In contrast, within-group comparisons revealed that automatic semantic activation was compromised in PD participants when off medication. The implications of these results for the neuromodulatory influence of dopamine on semantic processing in PD are discussed.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalNeuropsychology
Volume20
Issue number3
DOIs
Publication statusPublished - May 2006
Externally publishedYes

Fingerprint

Semantics
Parkinson Disease
Dopamine
Corpus Striatum
Sex Education
Levodopa
Control Groups
Research

Cite this

Angwin, Anthony J. ; Copland, David A. ; Chenery, Helen J. ; Murdoch, Bruce E. ; Silburn, Peter A. / The influence of dopamine on semantic activation in Parkinson's disease : Evidence from a multipriming task. In: Neuropsychology. 2006 ; Vol. 20, No. 3. pp. 299-306.
@article{8f041a73b1294deaa8cb5add42c43c1b,
title = "The influence of dopamine on semantic activation in Parkinson's disease: Evidence from a multipriming task",
abstract = "Research has suggested that semantic processing deficits in Parkinson's disease (PD) are related to striatal dopamine deficiency. As an investigation of the influence of dopamine on semantic activation in PD, 7 participants with PD performed a lexical-decision task when on and off levodopa medication. Seven healthy controls matched to the participants with PD in terms of sex, age, and education also participated in the study. By use of a multipriming paradigm, whereby 2 prime words were presented prior to the target word, semantic priming effects were measured across stimulus onset asynchronies (SOAs) of 250 ms and 1,200 ms. The results revealed a similar pattern of priming across SOAs for the control group and the PD participants on medication. In contrast, within-group comparisons revealed that automatic semantic activation was compromised in PD participants when off medication. The implications of these results for the neuromodulatory influence of dopamine on semantic processing in PD are discussed.",
author = "Angwin, {Anthony J.} and Copland, {David A.} and Chenery, {Helen J.} and Murdoch, {Bruce E.} and Silburn, {Peter A.}",
year = "2006",
month = "5",
doi = "10.1037/0894-4105.20.3.299",
language = "English",
volume = "20",
pages = "299--306",
journal = "Neuropsychology",
issn = "0894-4105",
publisher = "AMER PSYCHOLOGICAL ASSOC",
number = "3",

}

The influence of dopamine on semantic activation in Parkinson's disease : Evidence from a multipriming task. / Angwin, Anthony J.; Copland, David A.; Chenery, Helen J.; Murdoch, Bruce E.; Silburn, Peter A.

In: Neuropsychology, Vol. 20, No. 3, 05.2006, p. 299-306.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The influence of dopamine on semantic activation in Parkinson's disease

T2 - Evidence from a multipriming task

AU - Angwin, Anthony J.

AU - Copland, David A.

AU - Chenery, Helen J.

AU - Murdoch, Bruce E.

AU - Silburn, Peter A.

PY - 2006/5

Y1 - 2006/5

N2 - Research has suggested that semantic processing deficits in Parkinson's disease (PD) are related to striatal dopamine deficiency. As an investigation of the influence of dopamine on semantic activation in PD, 7 participants with PD performed a lexical-decision task when on and off levodopa medication. Seven healthy controls matched to the participants with PD in terms of sex, age, and education also participated in the study. By use of a multipriming paradigm, whereby 2 prime words were presented prior to the target word, semantic priming effects were measured across stimulus onset asynchronies (SOAs) of 250 ms and 1,200 ms. The results revealed a similar pattern of priming across SOAs for the control group and the PD participants on medication. In contrast, within-group comparisons revealed that automatic semantic activation was compromised in PD participants when off medication. The implications of these results for the neuromodulatory influence of dopamine on semantic processing in PD are discussed.

AB - Research has suggested that semantic processing deficits in Parkinson's disease (PD) are related to striatal dopamine deficiency. As an investigation of the influence of dopamine on semantic activation in PD, 7 participants with PD performed a lexical-decision task when on and off levodopa medication. Seven healthy controls matched to the participants with PD in terms of sex, age, and education also participated in the study. By use of a multipriming paradigm, whereby 2 prime words were presented prior to the target word, semantic priming effects were measured across stimulus onset asynchronies (SOAs) of 250 ms and 1,200 ms. The results revealed a similar pattern of priming across SOAs for the control group and the PD participants on medication. In contrast, within-group comparisons revealed that automatic semantic activation was compromised in PD participants when off medication. The implications of these results for the neuromodulatory influence of dopamine on semantic processing in PD are discussed.

UR - http://www.scopus.com/inward/record.url?scp=33745101639&partnerID=8YFLogxK

U2 - 10.1037/0894-4105.20.3.299

DO - 10.1037/0894-4105.20.3.299

M3 - Article

VL - 20

SP - 299

EP - 306

JO - Neuropsychology

JF - Neuropsychology

SN - 0894-4105

IS - 3

ER -