TY - JOUR
T1 - The Influence of 17‐β‐Oestradiol and the Natural Oestrous Cycle on α‐Adrenoceptor‐mediated Responses of the Cardiovascular System in the Rat
AU - Austin, Clare
AU - Chess-Williams, Russell
PY - 1995/1/1
Y1 - 1995/1/1
N2 - The effect of 17β‐oestradiol pretreatment and the natural oestrous cycle on responses of rat cardiac and vascular α‐adrenoceptors was investigated. It was found that treatment with the oestrogen had no effect on cardiac adrenoceptor sensitivity, while pretreatment with the hormone caused a significant increase in vascular α2‐, but not vascular α1‐adrenoceptor responsiveness. Pressor responses of pithed rats to selective oer or α2‐adrenoceptor agonists did not alter, however, during the natural oestrous cycle. These findings suggest that changes in oestrogen levels are capable of altering α‐adrenoceptor‐mediated vascular responses but that the relatively small changes in oestrogen which may occur throughout the natural oestrous cycle do not appear to alter the responses of these vascular α‐adrenoceptors. 1995 Royal Pharmaceutical Society of Great Britain
AB - The effect of 17β‐oestradiol pretreatment and the natural oestrous cycle on responses of rat cardiac and vascular α‐adrenoceptors was investigated. It was found that treatment with the oestrogen had no effect on cardiac adrenoceptor sensitivity, while pretreatment with the hormone caused a significant increase in vascular α2‐, but not vascular α1‐adrenoceptor responsiveness. Pressor responses of pithed rats to selective oer or α2‐adrenoceptor agonists did not alter, however, during the natural oestrous cycle. These findings suggest that changes in oestrogen levels are capable of altering α‐adrenoceptor‐mediated vascular responses but that the relatively small changes in oestrogen which may occur throughout the natural oestrous cycle do not appear to alter the responses of these vascular α‐adrenoceptors. 1995 Royal Pharmaceutical Society of Great Britain
UR - http://www.scopus.com/inward/record.url?scp=0029100954&partnerID=8YFLogxK
U2 - 10.1111/j.2042-7158.1995.tb05854.x
DO - 10.1111/j.2042-7158.1995.tb05854.x
M3 - Article
C2 - 8583367
AN - SCOPUS:0029100954
SN - 0022-3573
VL - 47
SP - 656
EP - 660
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 8
ER -