The Influence of 17‐β‐Oestradiol and the Natural Oestrous Cycle on α‐Adrenoceptor‐mediated Responses of the Cardiovascular System in the Rat

Clare Austin*, Russell Chess-Williams

*Corresponding author for this work

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8 Citations (Scopus)


The effect of 17β‐oestradiol pretreatment and the natural oestrous cycle on responses of rat cardiac and vascular α‐adrenoceptors was investigated. It was found that treatment with the oestrogen had no effect on cardiac adrenoceptor sensitivity, while pretreatment with the hormone caused a significant increase in vascular α2‐, but not vascular α1‐adrenoceptor responsiveness. Pressor responses of pithed rats to selective oer or α2‐adrenoceptor agonists did not alter, however, during the natural oestrous cycle. These findings suggest that changes in oestrogen levels are capable of altering α‐adrenoceptor‐mediated vascular responses but that the relatively small changes in oestrogen which may occur throughout the natural oestrous cycle do not appear to alter the responses of these vascular α‐adrenoceptors. 1995 Royal Pharmaceutical Society of Great Britain

Original languageEnglish
Pages (from-to)656-660
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Issue number8
Publication statusPublished - 1 Jan 1995
Externally publishedYes


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