The immune system in chronic fatigue syndrome/myalgic encephalomyelitis

E. W. Brenu, S. Marshall-Gradisnik, D. R. Staines

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a heterogeneous multifactorial disease characterised by severe fatigue and a range of systemic symptoms resulting in an inability to function at optimal levels. The symptoms of CFS/ME vary from patient to patient; however, prolonged and disabling fatigue, impaired memory and concentration and widespread pain are typical symptoms reported by most patients. There is no known single causal factor associated with CFS/ME although development of the condition post-infection is common. CFS/ME may affect the nervous, immune, endocrine, muscular, cardiovascular and respiratory systems. The present chapter reviews research pertaining to immunological function and other related areas in CFS/ME. Research has shown that CFS/ME patients exhibit abnormalities in immune function. The T, B and Natural Killer lymphocytes are cells frequently examined in CFS/ME. Gene expression studies are providing evidence for the over expression and under expression of genes important for homeostasis. In addition, alterations in the hypothalamic-pituitary-adrenal (HPA) axis occur. This review serves as a basis for further research in the aetiology of CFS/ME.

Original languageEnglish
Title of host publicationChronic Fatigue Syndrome: Symptoms, Causes and Prevention
EditorsEdita Svoboda, Kristof Zelenjcik
PublisherNova Science Publishers
Pages1-25
Number of pages25
ISBN (Print)9781607414933
Publication statusPublished - 2010
Externally publishedYes

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Chronic Fatigue Syndrome
Immune System
Fatigue
Research
Gene Expression
Endocrine System
Cardiovascular System

Cite this

Brenu, E. W., Marshall-Gradisnik, S., & Staines, D. R. (2010). The immune system in chronic fatigue syndrome/myalgic encephalomyelitis. In E. Svoboda, & K. Zelenjcik (Eds.), Chronic Fatigue Syndrome: Symptoms, Causes and Prevention (pp. 1-25). Nova Science Publishers.
Brenu, E. W. ; Marshall-Gradisnik, S. ; Staines, D. R. / The immune system in chronic fatigue syndrome/myalgic encephalomyelitis. Chronic Fatigue Syndrome: Symptoms, Causes and Prevention. editor / Edita Svoboda ; Kristof Zelenjcik. Nova Science Publishers, 2010. pp. 1-25
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Brenu, EW, Marshall-Gradisnik, S & Staines, DR 2010, The immune system in chronic fatigue syndrome/myalgic encephalomyelitis. in E Svoboda & K Zelenjcik (eds), Chronic Fatigue Syndrome: Symptoms, Causes and Prevention. Nova Science Publishers, pp. 1-25.

The immune system in chronic fatigue syndrome/myalgic encephalomyelitis. / Brenu, E. W.; Marshall-Gradisnik, S.; Staines, D. R.

Chronic Fatigue Syndrome: Symptoms, Causes and Prevention. ed. / Edita Svoboda; Kristof Zelenjcik. Nova Science Publishers, 2010. p. 1-25.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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Brenu EW, Marshall-Gradisnik S, Staines DR. The immune system in chronic fatigue syndrome/myalgic encephalomyelitis. In Svoboda E, Zelenjcik K, editors, Chronic Fatigue Syndrome: Symptoms, Causes and Prevention. Nova Science Publishers. 2010. p. 1-25