The honeypot randomized controlled trial statistical analysis plan

Elaine Mary Pascoe, Serigne Lo, Anish Scaria, Sunil V. Badve, Elaine Mary Beller, Alan Cass, Carmel Mary Hawley, David W. Johnson

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

{black diamond suit} Background: The HONEYPOT study is a multicenter, open-label, blinded-outcome, randomized controlled trial designed to determine whether, compared with standard topical application of mupirocin for nasal staphylococcal carriage, exit-site application of antibacterial honey reduces the rate of catheter-associated infections in peritoneal dialysis patients. {black diamond suit} Objective: To make public the pre-specified statistical analysis principles to be adhered to and the procedures to be performed by statisticians who will analyze the data for the HONEYPOT trial. {black diamond suit} Methods: Statisticians and clinical investigators who were blinded to treatment allocation and treatment-related study results and who will remain blinded until the central database is locked for final data extraction and analysis determined the statistical methods and procedures to be used for analysis and wrote the statistical analysis plan. The plan describes basic analysis principles, methods for dealing with a range of commonly encountered data analysis issues, and the specific statistical procedures for analyzing the primary, secondary, and safety outcomes. {black diamond suit} Results: A statistical analysis plan containing the pre-specified principles, methods, and procedures to be adhered to in the analysis of the data from the HONEYPOT trial was developed in accordance with international guidelines. The structure and content of the plan provide sufficient detail to meet the guidelines on statistical principles for clinical trials produced by the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. {black diamond suit} Conclusions: Making public the pre-specified statistical analysis plan for the HONEYPOT trial minimizes the potential for bias in the analysis of trial data and the interpretation and reporting of trial results.

Original languageEnglish
Pages (from-to)426-435
Number of pages10
JournalPeritoneal Dialysis International
Volume33
Issue number4
DOIs
Publication statusPublished - Jul 2013

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Randomized Controlled Trials
Mupirocin
Guidelines
Catheter-Related Infections
Honey
Peritoneal Dialysis
Nose
Research Design
Research Personnel
eriochrome black A
Clinical Trials
Databases
Safety
Therapeutics
Pharmaceutical Preparations

Cite this

Pascoe, E. M., Lo, S., Scaria, A., Badve, S. V., Beller, E. M., Cass, A., ... Johnson, D. W. (2013). The honeypot randomized controlled trial statistical analysis plan. Peritoneal Dialysis International, 33(4), 426-435. https://doi.org/10.3747/pdi.2012.00310
Pascoe, Elaine Mary ; Lo, Serigne ; Scaria, Anish ; Badve, Sunil V. ; Beller, Elaine Mary ; Cass, Alan ; Hawley, Carmel Mary ; Johnson, David W. / The honeypot randomized controlled trial statistical analysis plan. In: Peritoneal Dialysis International. 2013 ; Vol. 33, No. 4. pp. 426-435.
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Pascoe, EM, Lo, S, Scaria, A, Badve, SV, Beller, EM, Cass, A, Hawley, CM & Johnson, DW 2013, 'The honeypot randomized controlled trial statistical analysis plan' Peritoneal Dialysis International, vol. 33, no. 4, pp. 426-435. https://doi.org/10.3747/pdi.2012.00310

The honeypot randomized controlled trial statistical analysis plan. / Pascoe, Elaine Mary; Lo, Serigne; Scaria, Anish; Badve, Sunil V.; Beller, Elaine Mary; Cass, Alan; Hawley, Carmel Mary; Johnson, David W.

In: Peritoneal Dialysis International, Vol. 33, No. 4, 07.2013, p. 426-435.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - The honeypot randomized controlled trial statistical analysis plan

AU - Pascoe, Elaine Mary

AU - Lo, Serigne

AU - Scaria, Anish

AU - Badve, Sunil V.

AU - Beller, Elaine Mary

AU - Cass, Alan

AU - Hawley, Carmel Mary

AU - Johnson, David W.

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Y1 - 2013/7

N2 - {black diamond suit} Background: The HONEYPOT study is a multicenter, open-label, blinded-outcome, randomized controlled trial designed to determine whether, compared with standard topical application of mupirocin for nasal staphylococcal carriage, exit-site application of antibacterial honey reduces the rate of catheter-associated infections in peritoneal dialysis patients. {black diamond suit} Objective: To make public the pre-specified statistical analysis principles to be adhered to and the procedures to be performed by statisticians who will analyze the data for the HONEYPOT trial. {black diamond suit} Methods: Statisticians and clinical investigators who were blinded to treatment allocation and treatment-related study results and who will remain blinded until the central database is locked for final data extraction and analysis determined the statistical methods and procedures to be used for analysis and wrote the statistical analysis plan. The plan describes basic analysis principles, methods for dealing with a range of commonly encountered data analysis issues, and the specific statistical procedures for analyzing the primary, secondary, and safety outcomes. {black diamond suit} Results: A statistical analysis plan containing the pre-specified principles, methods, and procedures to be adhered to in the analysis of the data from the HONEYPOT trial was developed in accordance with international guidelines. The structure and content of the plan provide sufficient detail to meet the guidelines on statistical principles for clinical trials produced by the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. {black diamond suit} Conclusions: Making public the pre-specified statistical analysis plan for the HONEYPOT trial minimizes the potential for bias in the analysis of trial data and the interpretation and reporting of trial results.

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JO - Peritoneal Dialysis Bulletin

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