The effects of short term recombinant human growth hormone (rhGH) on blood rheology in healthy young males

S. B. Ramos, J. F. Brun, B. Gray, S. Rogerson, R. P. Weatherby, L. Tajouri, S. M. Marshall-Gradisnik

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Introduction: It has been shown that growth hormone (GH) exerts regulatory effects on hemorheology and other metabolic functions. GH stimulates the production of insulin-like growth factor I (IGF-I) and GH-IGF-I system has profound effects on body fluid status. There are speculations that GH has become widely used as a performance enhancing drug among athletes of various sports. The present study evaluated the possible hemorheological effects of short term administration of human recombinant growth hormone (rhGH) in healthy young males. Methodology: Thirty young healthy males (27 ± 9) participated in a 29 days study where it was administered either 0.9% sodium chloride or 1 mg of human rhGH from day 1 to day 7. The participants were randomly assigned into either placebo (C) n = 15 or rhGH 1 mg/day (rhGH) group n = 15. This study evaluated plasma fibrinogen levels, red blood cell (RBC) aggregation, deformability and serum IGF-I levels between and within the groups along 29 days. Results: There was a significant increase in erythrocytes aggregation index post injection (day 8), in accordance to an increase in serum IGF-I.

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalClinical Hemorheology and Microcirculation
Volume47
Issue number2
DOIs
Publication statusPublished - 2011

Fingerprint

Human Growth Hormone
Rheology
Growth Hormone
Insulin-Like Growth Factor I
Performance-Enhancing Substances
Hemorheology
Erythrocyte Aggregation
Cell Aggregation
Erythrocyte Indices
Body Fluids
Serum
Sodium Chloride
Athletes
Fibrinogen
Sports
Erythrocytes
Placebos
Injections

Cite this

Ramos, S. B. ; Brun, J. F. ; Gray, B. ; Rogerson, S. ; Weatherby, R. P. ; Tajouri, L. ; Marshall-Gradisnik, S. M. / The effects of short term recombinant human growth hormone (rhGH) on blood rheology in healthy young males. In: Clinical Hemorheology and Microcirculation. 2011 ; Vol. 47, No. 2. pp. 121-129.
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The effects of short term recombinant human growth hormone (rhGH) on blood rheology in healthy young males. / Ramos, S. B.; Brun, J. F.; Gray, B.; Rogerson, S.; Weatherby, R. P.; Tajouri, L.; Marshall-Gradisnik, S. M.

In: Clinical Hemorheology and Microcirculation, Vol. 47, No. 2, 2011, p. 121-129.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ramos, S. B.

AU - Brun, J. F.

AU - Gray, B.

AU - Rogerson, S.

AU - Weatherby, R. P.

AU - Tajouri, L.

AU - Marshall-Gradisnik, S. M.

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