TY - JOUR
T1 - The effects of low frequency Repetitive Transcranial Magnetic Stimulation (rTMS) and sham condition rTMS on behavioural language in chronic non-fluent aphasia
T2 - Short term outcomes
AU - Barwood, Caroline H S
AU - Murdoch, Bruce E.
AU - Whelan, Brooke Mai
AU - Lloyd, David
AU - Riek, Stephan
AU - O'Sullivan, John D.
AU - Coulthard, Alan
AU - Wong, Andrew
AU - Aitken, Phil
AU - Hall, Graham
PY - 2011
Y1 - 2011
N2 - Introduction: The application of low frequency (1 Hz) Repetitive Transcranial Magnetic Stimulation (rTMS) to right hemisphere (RH) language homologues in non-fluent aphasic populations has yielded improvements in behavioural language function, up to 43 months post stimulation [32]. Functional imaging studies have demonstrated RH language homologue " overactivation" post left inferior frontal gyrus (IFG) damage, in chronic non-fluent aphasia. The effects of low frequency (inhibitory) rTMS are postulated to be as a result of a reduction of overactivation in RH language homologues, facilitating the reorganisation of neural language networks. Methods: Low frequency (1 Hz) rTMS was applied to the anterior portion of a Broca's area homologue (pars triangularis), for 20 minutes per day for 10 days, using a stereotactic neuronavigational system. Twelve non-fluent aphasic patients (six real stimulation and six sham), 2-10 years post stroke were stimulated. Behavioural language outcome measures were taken at baseline and 1 week post rTMS. Results: Comparisons between the real stimulation and sham conditions indicated significant main effects between the stimulation and sham groups to 1 week post stimulation for naming accuracy, latency and repetition. Conclusions: This study indicates that rTMS has the capacity to modulate neural language networks, to facilitate improvements in behavioural language function, 1 week post TMS.
AB - Introduction: The application of low frequency (1 Hz) Repetitive Transcranial Magnetic Stimulation (rTMS) to right hemisphere (RH) language homologues in non-fluent aphasic populations has yielded improvements in behavioural language function, up to 43 months post stimulation [32]. Functional imaging studies have demonstrated RH language homologue " overactivation" post left inferior frontal gyrus (IFG) damage, in chronic non-fluent aphasia. The effects of low frequency (inhibitory) rTMS are postulated to be as a result of a reduction of overactivation in RH language homologues, facilitating the reorganisation of neural language networks. Methods: Low frequency (1 Hz) rTMS was applied to the anterior portion of a Broca's area homologue (pars triangularis), for 20 minutes per day for 10 days, using a stereotactic neuronavigational system. Twelve non-fluent aphasic patients (six real stimulation and six sham), 2-10 years post stroke were stimulated. Behavioural language outcome measures were taken at baseline and 1 week post rTMS. Results: Comparisons between the real stimulation and sham conditions indicated significant main effects between the stimulation and sham groups to 1 week post stimulation for naming accuracy, latency and repetition. Conclusions: This study indicates that rTMS has the capacity to modulate neural language networks, to facilitate improvements in behavioural language function, 1 week post TMS.
UR - http://www.scopus.com/inward/record.url?scp=79957857397&partnerID=8YFLogxK
U2 - 10.3233/NRE-2011-0640
DO - 10.3233/NRE-2011-0640
M3 - Article
C2 - 21447912
AN - SCOPUS:79957857397
SN - 1053-8135
VL - 28
SP - 113
EP - 128
JO - NeuroRehabilitation
JF - NeuroRehabilitation
IS - 2
ER -