The effects of low frequency Repetitive Transcranial Magnetic Stimulation (rTMS) and sham condition rTMS on behavioural language in chronic non-fluent aphasia: Short term outcomes

Caroline H S Barwood, Bruce E. Murdoch, Brooke Mai Whelan, David Lloyd, Stephan Riek, John D. O'Sullivan, Alan Coulthard, Andrew Wong, Phil Aitken, Graham Hall

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Abstract

Introduction: The application of low frequency (1 Hz) Repetitive Transcranial Magnetic Stimulation (rTMS) to right hemisphere (RH) language homologues in non-fluent aphasic populations has yielded improvements in behavioural language function, up to 43 months post stimulation [32]. Functional imaging studies have demonstrated RH language homologue " overactivation" post left inferior frontal gyrus (IFG) damage, in chronic non-fluent aphasia. The effects of low frequency (inhibitory) rTMS are postulated to be as a result of a reduction of overactivation in RH language homologues, facilitating the reorganisation of neural language networks. Methods: Low frequency (1 Hz) rTMS was applied to the anterior portion of a Broca's area homologue (pars triangularis), for 20 minutes per day for 10 days, using a stereotactic neuronavigational system. Twelve non-fluent aphasic patients (six real stimulation and six sham), 2-10 years post stroke were stimulated. Behavioural language outcome measures were taken at baseline and 1 week post rTMS. Results: Comparisons between the real stimulation and sham conditions indicated significant main effects between the stimulation and sham groups to 1 week post stimulation for naming accuracy, latency and repetition. Conclusions: This study indicates that rTMS has the capacity to modulate neural language networks, to facilitate improvements in behavioural language function, 1 week post TMS.

Original languageEnglish
Pages (from-to)113-128
Number of pages16
JournalNeuroRehabilitation
Volume28
Issue number2
DOIs
Publication statusPublished - 2011
Externally publishedYes

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Transcranial Magnetic Stimulation
Aphasia
Language
Prefrontal Cortex
Stroke
Outcome Assessment (Health Care)

Cite this

Barwood, Caroline H S ; Murdoch, Bruce E. ; Whelan, Brooke Mai ; Lloyd, David ; Riek, Stephan ; O'Sullivan, John D. ; Coulthard, Alan ; Wong, Andrew ; Aitken, Phil ; Hall, Graham. / The effects of low frequency Repetitive Transcranial Magnetic Stimulation (rTMS) and sham condition rTMS on behavioural language in chronic non-fluent aphasia : Short term outcomes. In: NeuroRehabilitation. 2011 ; Vol. 28, No. 2. pp. 113-128.
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abstract = "Introduction: The application of low frequency (1 Hz) Repetitive Transcranial Magnetic Stimulation (rTMS) to right hemisphere (RH) language homologues in non-fluent aphasic populations has yielded improvements in behavioural language function, up to 43 months post stimulation [32]. Functional imaging studies have demonstrated RH language homologue {"} overactivation{"} post left inferior frontal gyrus (IFG) damage, in chronic non-fluent aphasia. The effects of low frequency (inhibitory) rTMS are postulated to be as a result of a reduction of overactivation in RH language homologues, facilitating the reorganisation of neural language networks. Methods: Low frequency (1 Hz) rTMS was applied to the anterior portion of a Broca's area homologue (pars triangularis), for 20 minutes per day for 10 days, using a stereotactic neuronavigational system. Twelve non-fluent aphasic patients (six real stimulation and six sham), 2-10 years post stroke were stimulated. Behavioural language outcome measures were taken at baseline and 1 week post rTMS. Results: Comparisons between the real stimulation and sham conditions indicated significant main effects between the stimulation and sham groups to 1 week post stimulation for naming accuracy, latency and repetition. Conclusions: This study indicates that rTMS has the capacity to modulate neural language networks, to facilitate improvements in behavioural language function, 1 week post TMS.",
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Barwood, CHS, Murdoch, BE, Whelan, BM, Lloyd, D, Riek, S, O'Sullivan, JD, Coulthard, A, Wong, A, Aitken, P & Hall, G 2011, 'The effects of low frequency Repetitive Transcranial Magnetic Stimulation (rTMS) and sham condition rTMS on behavioural language in chronic non-fluent aphasia: Short term outcomes' NeuroRehabilitation, vol. 28, no. 2, pp. 113-128. https://doi.org/10.3233/NRE-2011-0640

The effects of low frequency Repetitive Transcranial Magnetic Stimulation (rTMS) and sham condition rTMS on behavioural language in chronic non-fluent aphasia : Short term outcomes. / Barwood, Caroline H S; Murdoch, Bruce E.; Whelan, Brooke Mai; Lloyd, David; Riek, Stephan; O'Sullivan, John D.; Coulthard, Alan; Wong, Andrew; Aitken, Phil; Hall, Graham.

In: NeuroRehabilitation, Vol. 28, No. 2, 2011, p. 113-128.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - The effects of low frequency Repetitive Transcranial Magnetic Stimulation (rTMS) and sham condition rTMS on behavioural language in chronic non-fluent aphasia

T2 - Short term outcomes

AU - Barwood, Caroline H S

AU - Murdoch, Bruce E.

AU - Whelan, Brooke Mai

AU - Lloyd, David

AU - Riek, Stephan

AU - O'Sullivan, John D.

AU - Coulthard, Alan

AU - Wong, Andrew

AU - Aitken, Phil

AU - Hall, Graham

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N2 - Introduction: The application of low frequency (1 Hz) Repetitive Transcranial Magnetic Stimulation (rTMS) to right hemisphere (RH) language homologues in non-fluent aphasic populations has yielded improvements in behavioural language function, up to 43 months post stimulation [32]. Functional imaging studies have demonstrated RH language homologue " overactivation" post left inferior frontal gyrus (IFG) damage, in chronic non-fluent aphasia. The effects of low frequency (inhibitory) rTMS are postulated to be as a result of a reduction of overactivation in RH language homologues, facilitating the reorganisation of neural language networks. Methods: Low frequency (1 Hz) rTMS was applied to the anterior portion of a Broca's area homologue (pars triangularis), for 20 minutes per day for 10 days, using a stereotactic neuronavigational system. Twelve non-fluent aphasic patients (six real stimulation and six sham), 2-10 years post stroke were stimulated. Behavioural language outcome measures were taken at baseline and 1 week post rTMS. Results: Comparisons between the real stimulation and sham conditions indicated significant main effects between the stimulation and sham groups to 1 week post stimulation for naming accuracy, latency and repetition. Conclusions: This study indicates that rTMS has the capacity to modulate neural language networks, to facilitate improvements in behavioural language function, 1 week post TMS.

AB - Introduction: The application of low frequency (1 Hz) Repetitive Transcranial Magnetic Stimulation (rTMS) to right hemisphere (RH) language homologues in non-fluent aphasic populations has yielded improvements in behavioural language function, up to 43 months post stimulation [32]. Functional imaging studies have demonstrated RH language homologue " overactivation" post left inferior frontal gyrus (IFG) damage, in chronic non-fluent aphasia. The effects of low frequency (inhibitory) rTMS are postulated to be as a result of a reduction of overactivation in RH language homologues, facilitating the reorganisation of neural language networks. Methods: Low frequency (1 Hz) rTMS was applied to the anterior portion of a Broca's area homologue (pars triangularis), for 20 minutes per day for 10 days, using a stereotactic neuronavigational system. Twelve non-fluent aphasic patients (six real stimulation and six sham), 2-10 years post stroke were stimulated. Behavioural language outcome measures were taken at baseline and 1 week post rTMS. Results: Comparisons between the real stimulation and sham conditions indicated significant main effects between the stimulation and sham groups to 1 week post stimulation for naming accuracy, latency and repetition. Conclusions: This study indicates that rTMS has the capacity to modulate neural language networks, to facilitate improvements in behavioural language function, 1 week post TMS.

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DO - 10.3233/NRE-2011-0640

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