The effects of H2 receptor antagonists on hepatic drug metabolism

D. A. Henry; M. J.S. Langman

The effects of H₂ receptor antagonists on hepatic drug metabolism

D. A. Henry, M. J.S. Langman

Research output: Contribution to journal › Meeting Abstract › Research › peer-review

Abstract

Antipyrine clearance and ¹⁴C aminopyrine breath analysis were measured before and during treatment with cimetidine. 1000 mg per day and ranitidine, 200 mg per day. Cimetidine, but not ranitidine, inhibited the oxidative metabolism of these two model drugs. These results suggest that metabolic inhibitory actions on the liver may be separated from H₂-antagonist effects.

Original language	English
Pages (from-to)	85-87
Number of pages	3
Journal	Scandinavian Journal of Gastroenterology, Supplement
Volume	16
Issue number	Suppl. 69
Publication status	Published - 1981
Externally published	Yes

Cite this

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title = "The effects of H2 receptor antagonists on hepatic drug metabolism",

abstract = "Antipyrine clearance and 14C aminopyrine breath analysis were measured before and during treatment with cimetidine. 1000 mg per day and ranitidine, 200 mg per day. Cimetidine, but not ranitidine, inhibited the oxidative metabolism of these two model drugs. These results suggest that metabolic inhibitory actions on the liver may be separated from H2-antagonist effects.",

author = "Henry, {D. A.} and Langman, {M. J.S.}",

year = "1981",

language = "English",

volume = "16",

pages = "85--87",

journal = "Scandinavian Journal of Gastroenterology, Supplement",

issn = "0085-5928",

publisher = "Taylor & Francis",

number = "Suppl. 69",

}

TY - JOUR

T1 - The effects of H2 receptor antagonists on hepatic drug metabolism

AU - Henry, D. A.

AU - Langman, M. J.S.

PY - 1981

Y1 - 1981

N2 - Antipyrine clearance and 14C aminopyrine breath analysis were measured before and during treatment with cimetidine. 1000 mg per day and ranitidine, 200 mg per day. Cimetidine, but not ranitidine, inhibited the oxidative metabolism of these two model drugs. These results suggest that metabolic inhibitory actions on the liver may be separated from H2-antagonist effects.

AB - Antipyrine clearance and 14C aminopyrine breath analysis were measured before and during treatment with cimetidine. 1000 mg per day and ranitidine, 200 mg per day. Cimetidine, but not ranitidine, inhibited the oxidative metabolism of these two model drugs. These results suggest that metabolic inhibitory actions on the liver may be separated from H2-antagonist effects.

UR - http://www.scopus.com/inward/record.url?scp=0019723564&partnerID=8YFLogxK

M3 - Meeting Abstract

C2 - 6119788

AN - SCOPUS:0019723564

SN - 0085-5928

VL - 16

SP - 85

EP - 87

JO - Scandinavian Journal of Gastroenterology, Supplement

JF - Scandinavian Journal of Gastroenterology, Supplement

IS - Suppl. 69

ER -

The effects of H₂ receptor antagonists on hepatic drug metabolism

Abstract

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