The Effects of COVID-19 on the Placenta During Pregnancy

Habib Sadeghi Rad, Joan Röhl, Nataly Stylianou, Mark C. Allenby, Sajad Razavi Bazaz, Majid E. Warkiani, Fernando S.F. Guimaraes, Vicki L. Clifton, Arutha Kulasinghe*

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

42 Citations (Scopus)
81 Downloads (Pure)


Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The virus primarily affects the lungs where it induces respiratory distress syndrome ranging from mild to acute, however, there is a growing body of evidence supporting its negative effects on other system organs that also carry the ACE2 receptor, such as the placenta. The majority of newborns delivered from SARS-CoV-2 positive mothers test negative following delivery, suggesting that there are protective mechanisms within the placenta. There appears to be a higher incidence of pregnancy-related complications in SARS-CoV-2 positive mothers, such as miscarriage, restricted fetal growth, or still-birth. In this review, we discuss the pathobiology of COVID-19 maternal infection and the potential adverse effects associated with viral infection, and the possibility of transplacental transmission.

Original languageEnglish
Article number743022
JournalFrontiers in Immunology
Publication statusPublished - 15 Sept 2021
Externally publishedYes


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