The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis

Thusharika Dissanayaka; Piumi Nakandala; Kavinda Malwanage; Aron T Hill; Deborah N Ashthree; Melissa M Lane; Nikolaj Travicia; Elizabeth Gamage; Wolfgang Marx; Shapour Jaberzadeh

doi:10.1016/j.neucli.2023.102921

The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis

Thusharika Dissanayaka^*, Piumi Nakandala, Kavinda Malwanage, Aron T Hill, Deborah N Ashthree, Melissa M Lane, Nikolaj Travicia, Elizabeth Gamage, Wolfgang Marx, Shapour Jaberzadeh

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Research › peer-review

5 Citations (Scopus)

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Abstract

OBJECTIVES: To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA).

METHODS: The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement.

RESULTS: Fourteen studies involving 740 people with KOA were included. In the meta-analysis, six studies compared a-tDCS alone with sham stimulation, and five studies compared a-tDCS combined with other methods with sham stimulation. We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) -0.52; 95% CI, -0.78 to -0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD -1.23; 95% CI, -1.59 to -0.88; P<0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision.

DISCUSSION AND CONCLUSION: A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings.

SIGNIFICANCE: A-tDCS can be used as a standalone and adjunct treatment for KOA.

STUDY REGISTRATION: PROSPERO number CRD42021255114.

Original language	English
Article number	102921
Pages (from-to)	1-14
Number of pages	14
Journal	Neurophysiologie Clinique
Volume	53
Issue number	6
DOIs	https://doi.org/10.1016/j.neucli.2023.102921
Publication status	Published - Dec 2023
Externally published	Yes

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10.1016/j.neucli.2023.102921Licence: CC BY

The effects of anodal tDCS on pain reduction in people with knee osteoarthritis A systematic review and meta-analysisFinal published version, 1.76 MBLicence: CC BY

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Dissanayaka, T., Nakandala, P., Malwanage, K., Hill, A. T., Ashthree, D. N., Lane, M. M., Travicia, N., Gamage, E., Marx, W., & Jaberzadeh, S. (2023). The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis. Neurophysiologie Clinique, 53(6), 1-14. Article 102921. https://doi.org/10.1016/j.neucli.2023.102921

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title = "The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis",

abstract = "OBJECTIVES: To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA).METHODS: The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement.RESULTS: Fourteen studies involving 740 people with KOA were included. In the meta-analysis, six studies compared a-tDCS alone with sham stimulation, and five studies compared a-tDCS combined with other methods with sham stimulation. We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) -0.52; 95% CI, -0.78 to -0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD -1.23; 95% CI, -1.59 to -0.88; P<0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision.DISCUSSION AND CONCLUSION: A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings.SIGNIFICANCE: A-tDCS can be used as a standalone and adjunct treatment for KOA.STUDY REGISTRATION: PROSPERO number CRD42021255114.",

author = "Thusharika Dissanayaka and Piumi Nakandala and Kavinda Malwanage and Hill, {Aron T} and Ashthree, {Deborah N} and Lane, {Melissa M} and Nikolaj Travicia and Elizabeth Gamage and Wolfgang Marx and Shapour Jaberzadeh",

year = "2023",

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doi = "10.1016/j.neucli.2023.102921",

language = "English",

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T1 - The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis

AU - Dissanayaka, Thusharika

AU - Nakandala, Piumi

AU - Malwanage, Kavinda

AU - Hill, Aron T

AU - Ashthree, Deborah N

AU - Lane, Melissa M

AU - Travicia, Nikolaj

AU - Gamage, Elizabeth

AU - Marx, Wolfgang

AU - Jaberzadeh, Shapour

PY - 2023/12

Y1 - 2023/12

N2 - OBJECTIVES: To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA).METHODS: The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement.RESULTS: Fourteen studies involving 740 people with KOA were included. In the meta-analysis, six studies compared a-tDCS alone with sham stimulation, and five studies compared a-tDCS combined with other methods with sham stimulation. We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) -0.52; 95% CI, -0.78 to -0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD -1.23; 95% CI, -1.59 to -0.88; P<0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision.DISCUSSION AND CONCLUSION: A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings.SIGNIFICANCE: A-tDCS can be used as a standalone and adjunct treatment for KOA.STUDY REGISTRATION: PROSPERO number CRD42021255114.

AB - OBJECTIVES: To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA).METHODS: The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement.RESULTS: Fourteen studies involving 740 people with KOA were included. In the meta-analysis, six studies compared a-tDCS alone with sham stimulation, and five studies compared a-tDCS combined with other methods with sham stimulation. We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) -0.52; 95% CI, -0.78 to -0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD -1.23; 95% CI, -1.59 to -0.88; P<0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision.DISCUSSION AND CONCLUSION: A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings.SIGNIFICANCE: A-tDCS can be used as a standalone and adjunct treatment for KOA.STUDY REGISTRATION: PROSPERO number CRD42021255114.

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SN - 0987-7053

VL - 53

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JO - Neurophysiologie Clinique

JF - Neurophysiologie Clinique

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M1 - 102921

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The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis

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Nutrition for Chronic Disease and Disability: Research to improve health related quality of life and bring forward the under-represented voice

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The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis

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Nutrition for Chronic Disease and Disability: Research to improve health related quality of life and bring forward the under-represented voice

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