The effect of streptozotocin-induced diabetes on cardiac β-adrenoceptor subtypes in the rat

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Abstract

1. The present study investigates the effect of short-term experimental diabetes of 14-days duration on the β-adrenoceptor subtypes of the rat heart. 2. β-adrenoceptor-mediated functional responses to submaximal doses of isoprenaline were enhanced in Langendorff-perfused hearts from diabetic rats, manifested as greater changes in tension, heart rate and rates of tension development (+dT/dt) and decline (-dT/dt). 3. Radioligand binding data demonstrated that total cardiac β-adrenoceptor density and affinity for [3H]-dihydroalprenolol was unchanged by diabetes, although a decrease in β1-adrenoceptor density and increase in β2-adrenoceptor density was observed. 4. In conclusion, hearts from 14-day streptozotocin-induced diabetic rats demonstrate a number of alterations within the β-adrenoceptor system. However, the enhanced β-adrenoceptor-mediated responses to isoprenaline were not caused by an overall increase in density of β-adrenoceptors, but were accompanied by changes in the ratio of the β-adrenoceptor subtypes.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalJournal of Autonomic Pharmacology
Volume21
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

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Experimental Diabetes Mellitus
Adrenergic Receptors
Isoproterenol
Dihydroalprenolol
Streptozocin
Heart Rate

Cite this

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title = "The effect of streptozotocin-induced diabetes on cardiac β-adrenoceptor subtypes in the rat",
abstract = "1. The present study investigates the effect of short-term experimental diabetes of 14-days duration on the β-adrenoceptor subtypes of the rat heart. 2. β-adrenoceptor-mediated functional responses to submaximal doses of isoprenaline were enhanced in Langendorff-perfused hearts from diabetic rats, manifested as greater changes in tension, heart rate and rates of tension development (+dT/dt) and decline (-dT/dt). 3. Radioligand binding data demonstrated that total cardiac β-adrenoceptor density and affinity for [3H]-dihydroalprenolol was unchanged by diabetes, although a decrease in β1-adrenoceptor density and increase in β2-adrenoceptor density was observed. 4. In conclusion, hearts from 14-day streptozotocin-induced diabetic rats demonstrate a number of alterations within the β-adrenoceptor system. However, the enhanced β-adrenoceptor-mediated responses to isoprenaline were not caused by an overall increase in density of β-adrenoceptors, but were accompanied by changes in the ratio of the β-adrenoceptor subtypes.",
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The effect of streptozotocin-induced diabetes on cardiac β-adrenoceptor subtypes in the rat. / Sellers, D. J.; Chess-Williams, R.

In: Journal of Autonomic Pharmacology, Vol. 21, No. 1, 2001, p. 15-21.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Chess-Williams, R.

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N2 - 1. The present study investigates the effect of short-term experimental diabetes of 14-days duration on the β-adrenoceptor subtypes of the rat heart. 2. β-adrenoceptor-mediated functional responses to submaximal doses of isoprenaline were enhanced in Langendorff-perfused hearts from diabetic rats, manifested as greater changes in tension, heart rate and rates of tension development (+dT/dt) and decline (-dT/dt). 3. Radioligand binding data demonstrated that total cardiac β-adrenoceptor density and affinity for [3H]-dihydroalprenolol was unchanged by diabetes, although a decrease in β1-adrenoceptor density and increase in β2-adrenoceptor density was observed. 4. In conclusion, hearts from 14-day streptozotocin-induced diabetic rats demonstrate a number of alterations within the β-adrenoceptor system. However, the enhanced β-adrenoceptor-mediated responses to isoprenaline were not caused by an overall increase in density of β-adrenoceptors, but were accompanied by changes in the ratio of the β-adrenoceptor subtypes.

AB - 1. The present study investigates the effect of short-term experimental diabetes of 14-days duration on the β-adrenoceptor subtypes of the rat heart. 2. β-adrenoceptor-mediated functional responses to submaximal doses of isoprenaline were enhanced in Langendorff-perfused hearts from diabetic rats, manifested as greater changes in tension, heart rate and rates of tension development (+dT/dt) and decline (-dT/dt). 3. Radioligand binding data demonstrated that total cardiac β-adrenoceptor density and affinity for [3H]-dihydroalprenolol was unchanged by diabetes, although a decrease in β1-adrenoceptor density and increase in β2-adrenoceptor density was observed. 4. In conclusion, hearts from 14-day streptozotocin-induced diabetic rats demonstrate a number of alterations within the β-adrenoceptor system. However, the enhanced β-adrenoceptor-mediated responses to isoprenaline were not caused by an overall increase in density of β-adrenoceptors, but were accompanied by changes in the ratio of the β-adrenoceptor subtypes.

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