The effect of streptozotocin-induced diabetes on cardiac β-adrenoceptor subtypes in the rat

D. J. Sellers*, R. Chess-Williams

*Corresponding author for this work

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14 Citations (Scopus)

Abstract

1. The present study investigates the effect of short-term experimental diabetes of 14-days duration on the β-adrenoceptor subtypes of the rat heart. 2. β-adrenoceptor-mediated functional responses to submaximal doses of isoprenaline were enhanced in Langendorff-perfused hearts from diabetic rats, manifested as greater changes in tension, heart rate and rates of tension development (+dT/dt) and decline (-dT/dt). 3. Radioligand binding data demonstrated that total cardiac β-adrenoceptor density and affinity for [3H]-dihydroalprenolol was unchanged by diabetes, although a decrease in β1-adrenoceptor density and increase in β2-adrenoceptor density was observed. 4. In conclusion, hearts from 14-day streptozotocin-induced diabetic rats demonstrate a number of alterations within the β-adrenoceptor system. However, the enhanced β-adrenoceptor-mediated responses to isoprenaline were not caused by an overall increase in density of β-adrenoceptors, but were accompanied by changes in the ratio of the β-adrenoceptor subtypes.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalJournal of Autonomic Pharmacology
Volume21
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

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