TY - JOUR
T1 - The effect of streptozotocin-induced diabetes on cardiac β-adrenoceptor subtypes in the rat
AU - Sellers, D. J.
AU - Chess-Williams, R.
PY - 2001
Y1 - 2001
N2 - 1. The present study investigates the effect of short-term experimental diabetes of 14-days duration on the β-adrenoceptor subtypes of the rat heart. 2. β-adrenoceptor-mediated functional responses to submaximal doses of isoprenaline were enhanced in Langendorff-perfused hearts from diabetic rats, manifested as greater changes in tension, heart rate and rates of tension development (+dT/dt) and decline (-dT/dt). 3. Radioligand binding data demonstrated that total cardiac β-adrenoceptor density and affinity for [3H]-dihydroalprenolol was unchanged by diabetes, although a decrease in β1-adrenoceptor density and increase in β2-adrenoceptor density was observed. 4. In conclusion, hearts from 14-day streptozotocin-induced diabetic rats demonstrate a number of alterations within the β-adrenoceptor system. However, the enhanced β-adrenoceptor-mediated responses to isoprenaline were not caused by an overall increase in density of β-adrenoceptors, but were accompanied by changes in the ratio of the β-adrenoceptor subtypes.
AB - 1. The present study investigates the effect of short-term experimental diabetes of 14-days duration on the β-adrenoceptor subtypes of the rat heart. 2. β-adrenoceptor-mediated functional responses to submaximal doses of isoprenaline were enhanced in Langendorff-perfused hearts from diabetic rats, manifested as greater changes in tension, heart rate and rates of tension development (+dT/dt) and decline (-dT/dt). 3. Radioligand binding data demonstrated that total cardiac β-adrenoceptor density and affinity for [3H]-dihydroalprenolol was unchanged by diabetes, although a decrease in β1-adrenoceptor density and increase in β2-adrenoceptor density was observed. 4. In conclusion, hearts from 14-day streptozotocin-induced diabetic rats demonstrate a number of alterations within the β-adrenoceptor system. However, the enhanced β-adrenoceptor-mediated responses to isoprenaline were not caused by an overall increase in density of β-adrenoceptors, but were accompanied by changes in the ratio of the β-adrenoceptor subtypes.
UR - http://www.scopus.com/inward/record.url?scp=0035723789&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2680.2001.00200.x
DO - 10.1046/j.1365-2680.2001.00200.x
M3 - Article
C2 - 11422574
AN - SCOPUS:0035723789
SN - 0144-1795
VL - 21
SP - 15
EP - 21
JO - Journal of Autonomic Pharmacology
JF - Journal of Autonomic Pharmacology
IS - 1
ER -
