The effect of resveratrol on cognitive performance: a systematic literature review and meta-analysis

Wolfgang Marx, Jaimon T Kelly, Skye Marshall, Jennifer Cutajar, Brigitte Annois, Andrew Pipingas, Audrey C Tierney, Catherine Itsiopoulos

Research output: Contribution to conferencePresentationResearch

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Abstract

Background: Due to the increasing burden of age-related
cognitive decline, interventions that can improve cognitive
performance are of interest. Resveratrol, a plant derived
polyphenol, has been reported to improve cognitive
performance in animal models and has recently been
investigated in several clinical trials. The aim of this systematic
review was to evaluate clinical trial data regarding the effect of
resveratrol on cognitive performance.
Methods: In accordance with PRISMA guidelines, a systematic
literature review and meta-analysis was conducted using the
following databases: MEDLINE, CINAHL, Cochrane, EMBASE
and Proquest. Studies included in this review stipulated that
the independent variable was resveratrol and used outcome
measures of cognitive performance. A meta-analysis was
conducted to determine treatment effect on the following
cognitive domains and mental processes: processing speed,
number facility, mood, and memory. Risk of bias was assessed
using the Cochrane Collaboration Risk of Bias tool; and quality
of the body of evidence assessed by GRADE.
Results: Ten clinical trials were included. Three studies
reported resveratrol to significantly improve some measures
of cognitive performance, two reported mixed findings, and
five reported no effect. When data was pooled, resveratrol
significantly improved delayed recognition, a measure of
working memory (SMD 0.39 [95% CI 0.08, 0.70]; I2=0%;
p=0.01; n=3 studies; n=166 participants; GRADE level:
moderate) and negative mood (SMD -0.18 [95% CI -0.31,
-0.05]; I2=0%; p=0.006; n=3 studies; n=163 participants;
GRADE level: moderate). Included studies generally had
low risk of bias and study outcomes were of moderate
or high quality. There was considerable heterogeneity in
the methodology of the included studies regarding the
intervention length, and participant age and disease status
Conclusion: The results of this systematic review indicate
that resveratrol might improve select measures of cognitive
performance; however, the current literature is inconsistent.
Future studies are recommended to focus on long-term
supplementation and adjustment for existing limitations such
as dietary polyphenol intake.
Original languageEnglish
Publication statusPublished - Nov 2017
Event43rd Annual Scientific Meeting of the Australasian Society for Parenteral and Enteral Nutrition: Collaboration in Clinical Nutrition – Evidence Based Nutrition for Improving Patient Outcomes - Royal Pines Conference Centre, Gold Coast, Australia
Duration: 16 Nov 201718 Nov 2017
Conference number: 43rd

Conference

Conference43rd Annual Scientific Meeting of the Australasian Society for Parenteral and Enteral Nutrition
Abbreviated titleAuSPEN 2017
CountryAustralia
CityGold Coast
Period16/11/1718/11/17

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Meta-Analysis
Clinical Trials
Mental Processes
Polyphenols
MEDLINE
Animal Models
Outcome Assessment (Health Care)
Databases
Guidelines
resveratrol

Cite this

Marx, W., Kelly, J. T., Marshall, S., Cutajar, J., Annois, B., Pipingas, A., ... Itsiopoulos, C. (2017). The effect of resveratrol on cognitive performance: a systematic literature review and meta-analysis. 43rd Annual Scientific Meeting of the Australasian Society for Parenteral and Enteral Nutrition, Gold Coast, Australia.
Marx, Wolfgang ; Kelly, Jaimon T ; Marshall, Skye ; Cutajar, Jennifer ; Annois, Brigitte ; Pipingas, Andrew ; Tierney, Audrey C ; Itsiopoulos, Catherine. / The effect of resveratrol on cognitive performance: a systematic literature review and meta-analysis. 43rd Annual Scientific Meeting of the Australasian Society for Parenteral and Enteral Nutrition, Gold Coast, Australia.
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abstract = "Background: Due to the increasing burden of age-relatedcognitive decline, interventions that can improve cognitiveperformance are of interest. Resveratrol, a plant derivedpolyphenol, has been reported to improve cognitiveperformance in animal models and has recently beeninvestigated in several clinical trials. The aim of this systematicreview was to evaluate clinical trial data regarding the effect ofresveratrol on cognitive performance.Methods: In accordance with PRISMA guidelines, a systematicliterature review and meta-analysis was conducted using thefollowing databases: MEDLINE, CINAHL, Cochrane, EMBASEand Proquest. Studies included in this review stipulated thatthe independent variable was resveratrol and used outcomemeasures of cognitive performance. A meta-analysis wasconducted to determine treatment effect on the followingcognitive domains and mental processes: processing speed,number facility, mood, and memory. Risk of bias was assessedusing the Cochrane Collaboration Risk of Bias tool; and qualityof the body of evidence assessed by GRADE.Results: Ten clinical trials were included. Three studiesreported resveratrol to significantly improve some measuresof cognitive performance, two reported mixed findings, andfive reported no effect. When data was pooled, resveratrolsignificantly improved delayed recognition, a measure ofworking memory (SMD 0.39 [95{\%} CI 0.08, 0.70]; I2=0{\%};p=0.01; n=3 studies; n=166 participants; GRADE level:moderate) and negative mood (SMD -0.18 [95{\%} CI -0.31,-0.05]; I2=0{\%}; p=0.006; n=3 studies; n=163 participants;GRADE level: moderate). Included studies generally hadlow risk of bias and study outcomes were of moderateor high quality. There was considerable heterogeneity inthe methodology of the included studies regarding theintervention length, and participant age and disease statusConclusion: The results of this systematic review indicatethat resveratrol might improve select measures of cognitiveperformance; however, the current literature is inconsistent.Future studies are recommended to focus on long-termsupplementation and adjustment for existing limitations suchas dietary polyphenol intake.",
author = "Wolfgang Marx and Kelly, {Jaimon T} and Skye Marshall and Jennifer Cutajar and Brigitte Annois and Andrew Pipingas and Tierney, {Audrey C} and Catherine Itsiopoulos",
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Marx, W, Kelly, JT, Marshall, S, Cutajar, J, Annois, B, Pipingas, A, Tierney, AC & Itsiopoulos, C 2017, 'The effect of resveratrol on cognitive performance: a systematic literature review and meta-analysis' 43rd Annual Scientific Meeting of the Australasian Society for Parenteral and Enteral Nutrition, Gold Coast, Australia, 16/11/17 - 18/11/17, .

The effect of resveratrol on cognitive performance: a systematic literature review and meta-analysis. / Marx, Wolfgang; Kelly, Jaimon T; Marshall, Skye; Cutajar, Jennifer; Annois, Brigitte; Pipingas, Andrew; Tierney, Audrey C; Itsiopoulos, Catherine.

2017. 43rd Annual Scientific Meeting of the Australasian Society for Parenteral and Enteral Nutrition, Gold Coast, Australia.

Research output: Contribution to conferencePresentationResearch

TY - CONF

T1 - The effect of resveratrol on cognitive performance: a systematic literature review and meta-analysis

AU - Marx, Wolfgang

AU - Kelly, Jaimon T

AU - Marshall, Skye

AU - Cutajar, Jennifer

AU - Annois, Brigitte

AU - Pipingas, Andrew

AU - Tierney, Audrey C

AU - Itsiopoulos, Catherine

PY - 2017/11

Y1 - 2017/11

N2 - Background: Due to the increasing burden of age-relatedcognitive decline, interventions that can improve cognitiveperformance are of interest. Resveratrol, a plant derivedpolyphenol, has been reported to improve cognitiveperformance in animal models and has recently beeninvestigated in several clinical trials. The aim of this systematicreview was to evaluate clinical trial data regarding the effect ofresveratrol on cognitive performance.Methods: In accordance with PRISMA guidelines, a systematicliterature review and meta-analysis was conducted using thefollowing databases: MEDLINE, CINAHL, Cochrane, EMBASEand Proquest. Studies included in this review stipulated thatthe independent variable was resveratrol and used outcomemeasures of cognitive performance. A meta-analysis wasconducted to determine treatment effect on the followingcognitive domains and mental processes: processing speed,number facility, mood, and memory. Risk of bias was assessedusing the Cochrane Collaboration Risk of Bias tool; and qualityof the body of evidence assessed by GRADE.Results: Ten clinical trials were included. Three studiesreported resveratrol to significantly improve some measuresof cognitive performance, two reported mixed findings, andfive reported no effect. When data was pooled, resveratrolsignificantly improved delayed recognition, a measure ofworking memory (SMD 0.39 [95% CI 0.08, 0.70]; I2=0%;p=0.01; n=3 studies; n=166 participants; GRADE level:moderate) and negative mood (SMD -0.18 [95% CI -0.31,-0.05]; I2=0%; p=0.006; n=3 studies; n=163 participants;GRADE level: moderate). Included studies generally hadlow risk of bias and study outcomes were of moderateor high quality. There was considerable heterogeneity inthe methodology of the included studies regarding theintervention length, and participant age and disease statusConclusion: The results of this systematic review indicatethat resveratrol might improve select measures of cognitiveperformance; however, the current literature is inconsistent.Future studies are recommended to focus on long-termsupplementation and adjustment for existing limitations suchas dietary polyphenol intake.

AB - Background: Due to the increasing burden of age-relatedcognitive decline, interventions that can improve cognitiveperformance are of interest. Resveratrol, a plant derivedpolyphenol, has been reported to improve cognitiveperformance in animal models and has recently beeninvestigated in several clinical trials. The aim of this systematicreview was to evaluate clinical trial data regarding the effect ofresveratrol on cognitive performance.Methods: In accordance with PRISMA guidelines, a systematicliterature review and meta-analysis was conducted using thefollowing databases: MEDLINE, CINAHL, Cochrane, EMBASEand Proquest. Studies included in this review stipulated thatthe independent variable was resveratrol and used outcomemeasures of cognitive performance. A meta-analysis wasconducted to determine treatment effect on the followingcognitive domains and mental processes: processing speed,number facility, mood, and memory. Risk of bias was assessedusing the Cochrane Collaboration Risk of Bias tool; and qualityof the body of evidence assessed by GRADE.Results: Ten clinical trials were included. Three studiesreported resveratrol to significantly improve some measuresof cognitive performance, two reported mixed findings, andfive reported no effect. When data was pooled, resveratrolsignificantly improved delayed recognition, a measure ofworking memory (SMD 0.39 [95% CI 0.08, 0.70]; I2=0%;p=0.01; n=3 studies; n=166 participants; GRADE level:moderate) and negative mood (SMD -0.18 [95% CI -0.31,-0.05]; I2=0%; p=0.006; n=3 studies; n=163 participants;GRADE level: moderate). Included studies generally hadlow risk of bias and study outcomes were of moderateor high quality. There was considerable heterogeneity inthe methodology of the included studies regarding theintervention length, and participant age and disease statusConclusion: The results of this systematic review indicatethat resveratrol might improve select measures of cognitiveperformance; however, the current literature is inconsistent.Future studies are recommended to focus on long-termsupplementation and adjustment for existing limitations suchas dietary polyphenol intake.

M3 - Presentation

ER -

Marx W, Kelly JT, Marshall S, Cutajar J, Annois B, Pipingas A et al. The effect of resveratrol on cognitive performance: a systematic literature review and meta-analysis. 2017. 43rd Annual Scientific Meeting of the Australasian Society for Parenteral and Enteral Nutrition, Gold Coast, Australia.