Projects per year
Methods: Randomised controlled trials in cancer patients aged >18 years were retrieved from 5 electronic databases;MEDLINE (via PubMed), EMBASE, CENTRAL, CINAHL (via EBSCOhost), and Web of Science, from database inceptionuntil 31st of December 2019. Trials supplementing ≥600 mg/d omega-3 PUFA (oral capsules, pure fish oil or oralnutritional supplements) or a control intervention for ≥3 weeks were included. Meta-analyses were performed in RevManto determine the mean differences (MD) in muscle mass and quality of life between omega-3 PUFA and control groupswith 95% confidence intervals (CI) and I2 for heterogeneity.
Results: We included 33 studies in patients with various types of cancers and degrees of malnutrition. The Cochrane riskof bias tool graded most trials as ‘unclear’ or ‘high’ risk of bias. Meta-analyses showed oral omega-3 PUFA supplementsimproved physical functioning (MD: 6.33; 95% CI: 0.32, 12.34, p=0.04; I2=0%) and potentially reduced fatigue (MD: -6.21;95% CI: -13.473, 1.05, p=0.09; I2=14%). However, there was no significant effect of omega-3 PUFA supplements onmuscle mass, global health status, emotional functioning and symptoms (nausea and vomiting, loss of appetite anddiarrhoea).
Conclusion: This review provides evidence for the benefits of oral omega-3 PUFA supplementation on quality of life butnot on muscle maintenance in patients with cancer. Well-designed large-scale randomised controlled trials inhomogenous patient cohorts are required to confirm these findings.
|Number of pages||667|
|Journal||Clinical Nutrition ESPEN|
|Early online date||9 Nov 2020|
|Publication status||Published - Dec 2020|
|Event||42nd ESPEN Virtual Congress - Online|
Duration: 19 Sep 2020 → 21 Sep 2020
Conference number: 42nd
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- 1 Non-HDR Student Supervision
Chung Nga Lam (Student ), Amanda Watt (Supervisor), Elizabeth Isenring (Supervisor), Marian de van der Schueren (Researcher) & Barbara Van der Meij (Supervisor)1 Sep 2018 → 30 Apr 2019
Activity: Professional Development, Mentorship, Supervision and Other Activities › Non-HDR Student Supervision
Related Research Outputs
- 1 Review article
The effect of oral omega-3 polyunsaturated fatty acid supplementation on muscle maintenance and quality of life in patients with cancer: A systematic review and meta-analysisLam, C. N., Watt, A. E., Isenring, E. A., de van der Schueren, M. A. E. & van der Meij, B. S., Jun 2021, In: Clinical Nutrition. 40, 6, p. 3815-3826 12 p.
Research output: Contribution to journal › Review article › Research › peer-review