The effect of ginger (Zingiber officinale) on platelet aggregation: A systematic literature review

Wolfgang Marx, Daniel McKavanagh, Alexandra L. McCarthy, Robert Bird, Karin Ried, Alexandre Chan, Liz Isenring

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Background. The potential effect of ginger on platelet aggregation is a widely-cited concern both within the published literature and to clinicians; however, there has been no systematic appraisal of the evidence to date. 

Methods. Using the PRISMA guidelines, we systematically reviewed the results of clinical and observational trials regarding the effect of ginger on platelet aggregation in adults compared to either placebo or baseline data. Studies included in this review stipulated the independent variable was a ginger preparation or isolated ginger compound, and used measures of platelet aggregation as the primary outcome. Results. Ten studies were included, comprising eight clinical trials and two observational studies. Of the eight clinical trials, four reported that ginger reduced platelet aggregation, while the remaining four reported no effect. The two observational studies also reported mixed findings.

Discussion. Many of the studies appraised for this review had moderate risks of bias. Methodology varied considerably between studies, notably the timeframe studied, dose of ginger used, and the characteristics of subjects recruited (e.g. healthy vs. patients with chronic diseases). 

Conclusion. The evidence that ginger affects platelet aggregation and coagulation is equivocal and further study is needed to definitively address this question.

Original languageEnglish
Article numbere0141119
JournalPLoS One
Volume10
Issue number10
DOIs
Publication statusPublished - 21 Oct 2015

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Ginger
Zingiber officinale
ginger
platelet aggregation
Platelets
Platelet Aggregation
Agglomeration
Clinical Trials
observational studies
Observational Studies
clinical trials
Coagulation
coagulation
chronic diseases
placebos
Chronic Disease
Placebos
Guidelines
dosage
methodology

Cite this

Marx, Wolfgang ; McKavanagh, Daniel ; McCarthy, Alexandra L. ; Bird, Robert ; Ried, Karin ; Chan, Alexandre ; Isenring, Liz. / The effect of ginger (Zingiber officinale) on platelet aggregation : A systematic literature review. In: PLoS One. 2015 ; Vol. 10, No. 10.
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abstract = "Background. The potential effect of ginger on platelet aggregation is a widely-cited concern both within the published literature and to clinicians; however, there has been no systematic appraisal of the evidence to date. Methods. Using the PRISMA guidelines, we systematically reviewed the results of clinical and observational trials regarding the effect of ginger on platelet aggregation in adults compared to either placebo or baseline data. Studies included in this review stipulated the independent variable was a ginger preparation or isolated ginger compound, and used measures of platelet aggregation as the primary outcome. Results. Ten studies were included, comprising eight clinical trials and two observational studies. Of the eight clinical trials, four reported that ginger reduced platelet aggregation, while the remaining four reported no effect. The two observational studies also reported mixed findings.Discussion. Many of the studies appraised for this review had moderate risks of bias. Methodology varied considerably between studies, notably the timeframe studied, dose of ginger used, and the characteristics of subjects recruited (e.g. healthy vs. patients with chronic diseases). Conclusion. The evidence that ginger affects platelet aggregation and coagulation is equivocal and further study is needed to definitively address this question.",
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The effect of ginger (Zingiber officinale) on platelet aggregation : A systematic literature review. / Marx, Wolfgang; McKavanagh, Daniel; McCarthy, Alexandra L.; Bird, Robert; Ried, Karin; Chan, Alexandre; Isenring, Liz.

In: PLoS One, Vol. 10, No. 10, e0141119, 21.10.2015.

Research output: Contribution to journalArticleResearchpeer-review

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