The effect of Alzheimer’s disease on the thalamus

Rasu Karki, Ahmed A. Moustafa

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review


While many prior studies and reviews focus on investigating the role of the hippocampus and cerebral cortex in memory formation and retrieval and how they are impacted by Alzheimer’s disease, other brain regions did not receive the same attention. Accordingly, in this chapter, we review various studies that discuss the impact of Alzheimer’s disease on the thalamus, a brain region important for information integration and in contributing to emotional, motivational, and cognitive processes. Importantly, we also discuss how disruptions to connections between the thalamus and other brain regions, including the hippocampus, Papez circuit, the retrosplenial cortex, thalamocortical network, and prefrontal-striatal network, are associated with Alzheimer’s disease. Our review suggests that future studies should further investigate the role of the thalamus in the development of Alzheimer’s disease and how lesions to the thalamus and its associated neural networks lead to different symptoms associated with Alzheimer’s disease.

Original languageEnglish
Title of host publicationAlzheimer’s Disease: Understanding Biomarkers, Big Data, and Therapy
PublisherAcademic Press
Number of pages17
ISBN (Electronic)9780128213346
Publication statusPublished - 2021
Externally publishedYes


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