The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans

Joanne Voisey, Christopher Dean Swagell, Ian Paul Hughes, Charles Phillip Morris, Angela Van Daal, Earnest P. Noble, Burnett Kann, Karen A. Heslop, Ross Mc D Young, Bruce Robert Lawford

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Abstract

Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatry disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq 1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain. Methods: To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD. Results: No significant association was found between PTSD and the Taq 1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C> T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P = 0.021). Conclusions: Our findings suggest that the 957C> T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD. .

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalDepression and Anxiety
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

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Veterans
Post-Traumatic Stress Disorders
Genes
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
Neuropsychiatry
Warfare
Dopamine
Schizophrenia
Alzheimer Disease
Alleles
Brain

Cite this

Voisey, J., Swagell, C. D., Hughes, I. P., Morris, C. P., Van Daal, A., Noble, E. P., ... Lawford, B. R. (2009). The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans. Depression and Anxiety, 26(1), 28-33. https://doi.org/10.1002/da.20517
Voisey, Joanne ; Swagell, Christopher Dean ; Hughes, Ian Paul ; Morris, Charles Phillip ; Van Daal, Angela ; Noble, Earnest P. ; Kann, Burnett ; Heslop, Karen A. ; Young, Ross Mc D ; Lawford, Bruce Robert. / The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans. In: Depression and Anxiety. 2009 ; Vol. 26, No. 1. pp. 28-33.
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abstract = "Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatry disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq 1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain. Methods: To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD. Results: No significant association was found between PTSD and the Taq 1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C> T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P = 0.021). Conclusions: Our findings suggest that the 957C> T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD. .",
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Voisey, J, Swagell, CD, Hughes, IP, Morris, CP, Van Daal, A, Noble, EP, Kann, B, Heslop, KA, Young, RMD & Lawford, BR 2009, 'The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans' Depression and Anxiety, vol. 26, no. 1, pp. 28-33. https://doi.org/10.1002/da.20517

The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans. / Voisey, Joanne; Swagell, Christopher Dean; Hughes, Ian Paul; Morris, Charles Phillip; Van Daal, Angela; Noble, Earnest P.; Kann, Burnett; Heslop, Karen A.; Young, Ross Mc D; Lawford, Bruce Robert.

In: Depression and Anxiety, Vol. 26, No. 1, 01.2009, p. 28-33.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans

AU - Voisey, Joanne

AU - Swagell, Christopher Dean

AU - Hughes, Ian Paul

AU - Morris, Charles Phillip

AU - Van Daal, Angela

AU - Noble, Earnest P.

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AU - Heslop, Karen A.

AU - Young, Ross Mc D

AU - Lawford, Bruce Robert

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