The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans

Joanne Voisey; Christopher Dean Swagell; Ian Paul Hughes; Charles Phillip Morris; Angela Van Daal; Earnest P. Noble; Burnett Kann; Karen A. Heslop; Ross Mc D Young; Bruce Robert Lawford

doi:10.1002/da.20517

The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans

Joanne Voisey^*, Christopher Dean Swagell, Ian Paul Hughes, Charles Phillip Morris, Angela Van Daal, Earnest P. Noble, Burnett Kann, Karen A. Heslop, Ross Mc D Young, Bruce Robert Lawford

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatry disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq 1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain. Methods: To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD. Results: No significant association was found between PTSD and the Taq 1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C> T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P = 0.021). Conclusions: Our findings suggest that the 957C> T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD. .

Original language	English
Pages (from-to)	28-33
Number of pages	6
Journal	Depression and Anxiety
Volume	26
Issue number	1
DOIs	https://doi.org/10.1002/da.20517
Publication status	Published - Jan 2009
Externally published	Yes

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The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veteransAccepted author manuscript, 113 KBLicence: Other

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title = "The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans",

abstract = "Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatry disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq 1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain. Methods: To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD. Results: No significant association was found between PTSD and the Taq 1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C> T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P = 0.021). Conclusions: Our findings suggest that the 957C> T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD. .",

author = "Joanne Voisey and Swagell, {Christopher Dean} and Hughes, {Ian Paul} and Morris, {Charles Phillip} and {Van Daal}, Angela and Noble, {Earnest P.} and Burnett Kann and Heslop, {Karen A.} and Young, {Ross Mc D} and Lawford, {Bruce Robert}",

year = "2009",

month = jan,

doi = "10.1002/da.20517",

language = "English",

volume = "26",

pages = "28--33",

journal = "Depression and Anxiety",

issn = "1091-4269",

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T1 - The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans

AU - Voisey, Joanne

AU - Swagell, Christopher Dean

AU - Hughes, Ian Paul

AU - Morris, Charles Phillip

AU - Van Daal, Angela

AU - Noble, Earnest P.

AU - Kann, Burnett

AU - Heslop, Karen A.

AU - Young, Ross Mc D

AU - Lawford, Bruce Robert

PY - 2009/1

Y1 - 2009/1

N2 - Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatry disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq 1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain. Methods: To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD. Results: No significant association was found between PTSD and the Taq 1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C> T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P = 0.021). Conclusions: Our findings suggest that the 957C> T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD. .

AB - Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatry disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq 1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain. Methods: To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD. Results: No significant association was found between PTSD and the Taq 1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C> T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P = 0.021). Conclusions: Our findings suggest that the 957C> T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD. .

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EP - 33

JO - Depression and Anxiety

JF - Depression and Anxiety

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ER -

The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans

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