Recent research suggests that individuals reward honesty more than they punish deception. Five experiments showed that different patterns of rewards and punishments emerge for North American and East Asian cultures. Experiment 1 demonstrated that Americans rewarded more than they punished, whereas East Asians rewarded and punished in equivalent amounts. Experiments 2 and 3 revealed that these divergent patterns by culture could be explained by greater social mobility experienced by Americans. Experiments 4 and 5 examined how certain consequences of social mobility, approach-avoidance behavioral motivations and trust and felt obligation, can lead to disparate reward and punishment decisions within the two cultures. Moreover, Experiment 4 revealed that Americans exhibited stronger evaluative reactions toward deception but stronger behavioral intentions toward honesty; East Asians did not exhibit this evaluative-behavioral asymmetry. The cross-cultural implications for understanding rewards and punishments in an increasingly globalized world are discussed.