The connection between PARP14 and SARS-CoV-2

Amanda L Tauber, Stephanie S Schweiker, Stephan M Levonis*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review


In our 2021 article, we explored the overlap between the SARS-CoV-2 infe ction and the activity of the poly (ADP-ribose) polymerase family member 14 (PARP14)[1]. We identified three key actions including, PARP14 counterbalancing the pro-inflammatory cytokines of SARS-CoV-2 cytokine storm, PARP14’s role in the interferon (IFN) response to aid in clearing the virus and how this may be combatted by the de-mono (ADP-ribosyl) ation (MARylating) activity of the coronavirus macrodomain.
Original languageEnglish
JournalFuture Medicinal Chemistry
Issue number3
Publication statusPublished - 3 Feb 2023


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