The connection between PARP14 and SARS-CoV-2

Amanda L Tauber; Stephanie S Schweiker; Stephan M Levonis

doi:https://doi.org/10.4155/fmc-2023-0013

The connection between PARP14 and SARS-CoV-2

Amanda L Tauber, Stephanie S Schweiker, Stephan M Levonis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

In our 2021 article, we explored the overlap between the SARS-CoV-2 infe ction and the activity of the poly (ADP-ribose) polymerase family member 14 (PARP14)[1]. We identified three key actions including, PARP14 counterbalancing the pro-inflammatory cytokines of SARS-CoV-2 cytokine storm, PARP14’s role in the interferon (IFN) response to aid in clearing the virus and how this may be combatted by the de-mono (ADP-ribosyl) ation (MARylating) activity of the coronavirus macrodomain.

Original language	English
Journal	Future Medicinal Chemistry
Volume	15
Issue number	3
DOIs	https://doi.org/10.4155/fmc-2023-0013
Publication status	Published - 3 Feb 2023

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1 Article

The potential association between PARP14 and SARS-CoV-2 infection (COVID-19)
Tauber, A. L., Schweiker, S. S. & Levonis, S. M., Mar 2021, In: Future Medicinal Chemistry. 13, 6, p. 587-592 6 p.
Research output: Contribution to journal › Article › Research › peer-review

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abstract = "In our 2021 article, we explored the overlap between the SARS-CoV-2 infe ction and the activity of the poly (ADP-ribose) polymerase family member 14 (PARP14)[1]. We identified three key actions including, PARP14 counterbalancing the pro-inflammatory cytokines of SARS-CoV-2 cytokine storm, PARP14{\textquoteright}s role in the interferon (IFN) response to aid in clearing the virus and how this may be combatted by the de-mono (ADP-ribosyl) ation (MARylating) activity of the coronavirus macrodomain.",

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The connection between PARP14 and SARS-CoV-2

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The potential association between PARP14 and SARS-CoV-2 infection (COVID-19)

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