The association between dietary patterns and the novel inflammatory markers platelet-activating factor and lipoprotein-associated phospholipase A2: a systematic review

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    Abstract

    CONTEXT: Atherosclerosis is a disease of chronic inflammation. Recent research has identified 2 novel inflammatory biomarkers: platelet-activating factor (PAF) and lipoprotein-associated phospholipase A2 (Lp-PLA2). Diet has been proposed as a mediator of inflammation, but to date, the focus for these novel biomarkers has been on individual foods and nutrients rather than overall dietary patterns.

    OBJECTIVE: To systematically review the literature on the association between dietary patterns and PAF and Lp-PLA2.

    DATA SOURCES: The PubMed, Embase, CINAHL, and Cochrane CENTRAL literature databases were searched.

    DATA ANALYSIS: Study quality was evaluated using the Quality Criteria Checklist. Sixteen studies (n = 4 observational and n = 12 interventional) were included and assessed for associations between dietary patterns and PAF and Lp-PLA2.

    CONCLUSION: Study quality varied from neutral (n = 10) to positive (n = 6). Mediterranean, heart healthy, and vegetarian dietary patterns were associated with improved levels of PAF and Lp-PLA2. Conversely, Western dietary patterns were less favorable. A range of well-established, healthier dietary patterns may lower inflammation and the risk of atherosclerosis. More well-designed studies are needed to confirm these findings and identify other dietary patterns that improve inflammation.

    Original languageEnglish
    Article numbernuab051
    Pages (from-to)1371-1391
    Number of pages21
    JournalNutrition Reviews
    Volume80
    Issue number6
    Early online date13 Oct 2021
    DOIs
    Publication statusPublished - 1 Jun 2022

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