The [14C]‐aminopyrine breath test. A comparison of different forms of analysis

DA Henry*, G. Sharpe, S. Chaplain, S. Cartwright, G. Kitchingman, GD Bell, MJ Langman

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)


1 Following ingestion of [14C]‐aminopyrine, breath 14CO2 data were analysed from normal individuals, patients with hepatic disease, epileptics receiving anticonvulsant therapy and volunteers before and after treatment with glutethimide. 

2 The ‘standard’ 2 h [14C]‐ aminopyrine breath test discriminated successfully between the main groups but failed to detect the change in microsomal enzyme function produced by glutethimide.

 3 A ‘modified’ form of the 2 h breath test calculated from the area under the breath specific activity curve detected the increase in demethylation following glutethimide. 

4 The breath elimination constant (Kb) derived from the breath 14CO2 disappearance curve was as sensitive as the ‘modified’ 2 h breath test and was simpler to compute. 

5 Glutethimide 500 mg/day for 14 days resulted in a 42% increase in the metabolic clearance of antipyrine and a 26% increase in demethylation of [14C]‐aminopyrine. 1979 The British Pharmacological Society

Original languageEnglish
Pages (from-to)539-545
Number of pages7
JournalBritish Journal of Clinical Pharmacology
Issue number6
Publication statusPublished - Dec 1979
Externally publishedYes


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