The [14C]‐aminopyrine breath test. A comparison of different forms of analysis

DA Henry; G. Sharpe; S. Chaplain; S. Cartwright; G. Kitchingman; GD Bell; MJ Langman

doi:10.1111/j.1365-2125.1979.tb01041.x

The [14C]‐aminopyrine breath test. A comparison of different forms of analysis

DA Henry^*, G. Sharpe, S. Chaplain, S. Cartwright, G. Kitchingman, GD Bell, MJ Langman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

1 Following ingestion of [14C]‐aminopyrine, breath 14CO2 data were analysed from normal individuals, patients with hepatic disease, epileptics receiving anticonvulsant therapy and volunteers before and after treatment with glutethimide.

2 The ‘standard’ 2 h [14C]‐ aminopyrine breath test discriminated successfully between the main groups but failed to detect the change in microsomal enzyme function produced by glutethimide.

3 A ‘modified’ form of the 2 h breath test calculated from the area under the breath specific activity curve detected the increase in demethylation following glutethimide.

4 The breath elimination constant (Kb) derived from the breath 14CO2 disappearance curve was as sensitive as the ‘modified’ 2 h breath test and was simpler to compute.

5 Glutethimide 500 mg/day for 14 days resulted in a 42% increase in the metabolic clearance of antipyrine and a 26% increase in demethylation of [14C]‐aminopyrine. 1979 The British Pharmacological Society

Original language	English
Pages (from-to)	539-545
Number of pages	7
Journal	British Journal of Clinical Pharmacology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2125.1979.tb01041.x
Publication status	Published - Dec 1979
Externally published	Yes

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title = "The [14C]‐aminopyrine breath test. A comparison of different forms of analysis",

abstract = "1 Following ingestion of [14C]‐aminopyrine, breath 14CO2 data were analysed from normal individuals, patients with hepatic disease, epileptics receiving anticonvulsant therapy and volunteers before and after treatment with glutethimide. 2 The {\textquoteleft}standard{\textquoteright} 2 h [14C]‐ aminopyrine breath test discriminated successfully between the main groups but failed to detect the change in microsomal enzyme function produced by glutethimide. 3 A {\textquoteleft}modified{\textquoteright} form of the 2 h breath test calculated from the area under the breath specific activity curve detected the increase in demethylation following glutethimide. 4 The breath elimination constant (Kb) derived from the breath 14CO2 disappearance curve was as sensitive as the {\textquoteleft}modified{\textquoteright} 2 h breath test and was simpler to compute. 5 Glutethimide 500 mg/day for 14 days resulted in a 42% increase in the metabolic clearance of antipyrine and a 26% increase in demethylation of [14C]‐aminopyrine. 1979 The British Pharmacological Society",

author = "DA Henry and G. Sharpe and S. Chaplain and S. Cartwright and G. Kitchingman and GD Bell and MJ Langman",

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AU - Sharpe, G.

AU - Chaplain, S.

AU - Cartwright, S.

AU - Kitchingman, G.

AU - Bell, GD

AU - Langman, MJ

PY - 1979/12

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N2 - 1 Following ingestion of [14C]‐aminopyrine, breath 14CO2 data were analysed from normal individuals, patients with hepatic disease, epileptics receiving anticonvulsant therapy and volunteers before and after treatment with glutethimide. 2 The ‘standard’ 2 h [14C]‐ aminopyrine breath test discriminated successfully between the main groups but failed to detect the change in microsomal enzyme function produced by glutethimide. 3 A ‘modified’ form of the 2 h breath test calculated from the area under the breath specific activity curve detected the increase in demethylation following glutethimide. 4 The breath elimination constant (Kb) derived from the breath 14CO2 disappearance curve was as sensitive as the ‘modified’ 2 h breath test and was simpler to compute. 5 Glutethimide 500 mg/day for 14 days resulted in a 42% increase in the metabolic clearance of antipyrine and a 26% increase in demethylation of [14C]‐aminopyrine. 1979 The British Pharmacological Society

AB - 1 Following ingestion of [14C]‐aminopyrine, breath 14CO2 data were analysed from normal individuals, patients with hepatic disease, epileptics receiving anticonvulsant therapy and volunteers before and after treatment with glutethimide. 2 The ‘standard’ 2 h [14C]‐ aminopyrine breath test discriminated successfully between the main groups but failed to detect the change in microsomal enzyme function produced by glutethimide. 3 A ‘modified’ form of the 2 h breath test calculated from the area under the breath specific activity curve detected the increase in demethylation following glutethimide. 4 The breath elimination constant (Kb) derived from the breath 14CO2 disappearance curve was as sensitive as the ‘modified’ 2 h breath test and was simpler to compute. 5 Glutethimide 500 mg/day for 14 days resulted in a 42% increase in the metabolic clearance of antipyrine and a 26% increase in demethylation of [14C]‐aminopyrine. 1979 The British Pharmacological Society

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ER -

The [14C]‐aminopyrine breath test. A comparison of different forms of analysis

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