Targeted text messaging support for patients with coronary heart disease-reply

In Reply The TEXT ME study was a randomized clinical trial designed to evaluate the effects of a mobile phone text messaging support program in addition to the standard secondary preventive care offered to patients with coronary heart disease. The primary outcome of the study was level of plasma LDL-C at 6 months, and the trial was designed to study the mean difference between the intervention and control group at that point. We used analysis of covariance to analyze outcomes with the baseline values as covariates1; analysis of variance of change from baseline was not used in any of the analyses. This is explained in footnote 2 of the end points table (Table 2 in the article), and the statistical comparisons in this table refer to the differences between the 2 randomized groups at 6 months, rather than change within a particular group from baseline.