T helper cell cytokine profiles after endurance exercise

Michael W. Kakanis, Jonathan Peake, Ekua W. Brenu, Michael Simmonds, Bon Gray, Sonya M. Marshall-Gradisnik

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Abstract

Endurance exercise can cause immunosuppression and increase the risk of upper respiratory illness. The present study examined changes in the secretion of T helper (Th) cell cytokines after endurance exercise. Ten highly trained road cyclists [mean±SEM: age 24.2±1.7 years; height 1.82±0.02 m; body mass 73.8±2.0 kg; peak oxygen uptake 65.9±2.3 mL/(kg·;min)] performed 2 h of cycling exercise at 90% of the second ventilatory threshold. Peripheral blood mononuclear cells were isolated and stimulated with phytohemagglutinin. Plasma cortisol concentrations and the concentration of Th1/Th2/Th17 cell cytokines were examined. Data were analyzed using both traditional statistics and magnitude-based inferences. Results revealed a significant decrease in plasma cortisol at 4-24 h postexercise compared with pre-exercise values. Qualitative analysis revealed postexercise changes in concentrations of plasma cortisol, IL-2, TNF, IL-4, IL-6, IL-10, and IL-17A compared with pre-exercise values. A Th1/Th2 shift was evident immediately postexercise. Furthermore, for multiple cytokines, including IL-2 and TNF (Th1), IL-6 and IL-10 (Th2), and IL-17 (Th17), no meaningful change in concentration occurred until more than 4 h postexercise, highlighting the duration of exercise-induced changes in immune function. These results demonstrate the importance of considering "clinically" significant versus statistically significant changes in immune cell function after exercise.

Original languageEnglish
Pages (from-to)699-706
Number of pages8
JournalJournal of Interferon and Cytokine Research
Volume34
Issue number9
DOIs
Publication statusPublished - 1 Sep 2014

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Interleukin-17
Helper-Inducer T-Lymphocytes
Hydrocortisone
Cytokines
Interleukin-10
Interleukin-2
Interleukin-6
Phytohemagglutinins
Interleukin-4
Immunosuppression
Blood Cells
Oxygen

Cite this

Kakanis, M. W., Peake, J., Brenu, E. W., Simmonds, M., Gray, B., & Marshall-Gradisnik, S. M. (2014). T helper cell cytokine profiles after endurance exercise. Journal of Interferon and Cytokine Research, 34(9), 699-706. https://doi.org/10.1089/jir.2013.0031
Kakanis, Michael W. ; Peake, Jonathan ; Brenu, Ekua W. ; Simmonds, Michael ; Gray, Bon ; Marshall-Gradisnik, Sonya M. / T helper cell cytokine profiles after endurance exercise. In: Journal of Interferon and Cytokine Research. 2014 ; Vol. 34, No. 9. pp. 699-706.
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Kakanis, MW, Peake, J, Brenu, EW, Simmonds, M, Gray, B & Marshall-Gradisnik, SM 2014, 'T helper cell cytokine profiles after endurance exercise' Journal of Interferon and Cytokine Research, vol. 34, no. 9, pp. 699-706. https://doi.org/10.1089/jir.2013.0031

T helper cell cytokine profiles after endurance exercise. / Kakanis, Michael W.; Peake, Jonathan; Brenu, Ekua W.; Simmonds, Michael; Gray, Bon; Marshall-Gradisnik, Sonya M.

In: Journal of Interferon and Cytokine Research, Vol. 34, No. 9, 01.09.2014, p. 699-706.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Kakanis, Michael W.

AU - Peake, Jonathan

AU - Brenu, Ekua W.

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AU - Gray, Bon

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Kakanis MW, Peake J, Brenu EW, Simmonds M, Gray B, Marshall-Gradisnik SM. T helper cell cytokine profiles after endurance exercise. Journal of Interferon and Cytokine Research. 2014 Sep 1;34(9):699-706. https://doi.org/10.1089/jir.2013.0031