Projects per year
Metastatic breast cancer (MBC) affects approximately 20-30 percent of women with breast cancer. Current treatment options improve survival, however disease- or treatment related symptoms and muscle wasting are increasingly common and significantly decrease patients’ quality of life.
This systematic review aimed to evaluate the evidence for lifestyle interventions on body composition in women with MBC to inform future research. Secondary outcomes of interest were fatigue, quality of life (QoL), survival, and toxicity, and depression. Pubmed, CINAHL, Cochrane Central and EMBASE databases were searched from database inception to July 2018. All prospective randomised and non-randomised studies that investigated the effect of exercise and/or nutrition interventions were included. Two independent reviewers performed the search, extracted data and conducted the analysis.
In total, only 7 studies were eligible for review, of which 3 were randomised controlled trials. No studies were were identified that investigated the effects of lifestyle interventions on body composition in this population. Seven studies reported that exercise interventions, over a minimum duration of 4 weeks, found lower patient-reported fatigue, improved QoL and longer survival. All included studies were judged of low quality (low statistical power, small sample sizes, diverse study designs, and reliance on patient-reported data).
To date, there is insufficient evidence to draw firm conclusions regarding the impact of lifestyle interventions in MBC. Clinical practice is largely based on studies that have been performed in patients receiving curative treatment for breast cancer. Future research demands innovative, high-quality, large sample, randomised controlled trials to inform evidence-based guidelines on diet, mode, frequency and intensity of exercise for optimal body composition and QoL.
|Publication status||Published - 2018|
|Event||The 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition: Building the Bridge – Building excellence in clinical nutrition - Sheraton on the Park, Sydney, Australia|
Duration: 29 Nov 2018 → 1 Dec 2018
Conference number: 44th
|Conference||The 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition|
|Period||29/11/18 → 1/12/18|
Isenring, E., Marshall, S., Reidlinger, D., Kelly, J., Cox, G., Van der Meij, B., MacKenzie-Shalders, K., Mayr, H., Dahl, C., Crichton, M., O'Bryan, K. R., Norris, R., Warner, M., Davidson, A., Naranjo, A., Mahoney, S., Eberhardt, F., Dalwood, P., Lopez, E., Hofto, S., Innerarity, C., So, D., McIntosh, A., Gadd, N., Chan, H. C. (., Lan, X., Fei, X. (., Kostjasyn, S., Adhyaru, P., Giang, J., Leung, E. L. Y., Strike, K., Pearcy, J., Somani, A., Wright, C., Matthews, C. & Lee, G.
1/01/14 → 31/12/27
Celia Innerarity (Student ), Amelia Bandera (Student ), Jaimon Kelly (Supervisor), David Honeyman (Researcher) & Barbara Van der Meij (Supervisor)1 Sep 2017 → 30 Apr 2018
Activity: Professional Development, Mentorship, Supervision and Other Activities › Non-HDR Student Supervision