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Abstract
Background
Metastatic breast cancer (MBC) affects approximately 20-30 percent of women with breast cancer. Current treatment options improve survival, however disease- or treatment related symptoms and muscle wasting are increasingly common and significantly decrease patients’ quality of life.
Methods
This systematic review aimed to evaluate the evidence for lifestyle interventions on body composition in women with MBC to inform future research. Secondary outcomes of interest were fatigue, quality of life (QoL), survival, and toxicity, and depression. Pubmed, CINAHL, Cochrane Central and EMBASE databases were searched from database inception to July 2018. All prospective randomised and non-randomised studies that investigated the effect of exercise and/or nutrition interventions were included. Two independent reviewers performed the search, extracted data and conducted the analysis.
Results
In total, only 7 studies were eligible for review, of which 3 were randomised controlled trials. No studies were were identified that investigated the effects of lifestyle interventions on body composition in this population. Seven studies reported that exercise interventions, over a minimum duration of 4 weeks, found lower patient-reported fatigue, improved QoL and longer survival. All included studies were judged of low quality (low statistical power, small sample sizes, diverse study designs, and reliance on patient-reported data).
Conclusions
To date, there is insufficient evidence to draw firm conclusions regarding the impact of lifestyle interventions in MBC. Clinical practice is largely based on studies that have been performed in patients receiving curative treatment for breast cancer. Future research demands innovative, high-quality, large sample, randomised controlled trials to inform evidence-based guidelines on diet, mode, frequency and intensity of exercise for optimal body composition and QoL.
Metastatic breast cancer (MBC) affects approximately 20-30 percent of women with breast cancer. Current treatment options improve survival, however disease- or treatment related symptoms and muscle wasting are increasingly common and significantly decrease patients’ quality of life.
Methods
This systematic review aimed to evaluate the evidence for lifestyle interventions on body composition in women with MBC to inform future research. Secondary outcomes of interest were fatigue, quality of life (QoL), survival, and toxicity, and depression. Pubmed, CINAHL, Cochrane Central and EMBASE databases were searched from database inception to July 2018. All prospective randomised and non-randomised studies that investigated the effect of exercise and/or nutrition interventions were included. Two independent reviewers performed the search, extracted data and conducted the analysis.
Results
In total, only 7 studies were eligible for review, of which 3 were randomised controlled trials. No studies were were identified that investigated the effects of lifestyle interventions on body composition in this population. Seven studies reported that exercise interventions, over a minimum duration of 4 weeks, found lower patient-reported fatigue, improved QoL and longer survival. All included studies were judged of low quality (low statistical power, small sample sizes, diverse study designs, and reliance on patient-reported data).
Conclusions
To date, there is insufficient evidence to draw firm conclusions regarding the impact of lifestyle interventions in MBC. Clinical practice is largely based on studies that have been performed in patients receiving curative treatment for breast cancer. Future research demands innovative, high-quality, large sample, randomised controlled trials to inform evidence-based guidelines on diet, mode, frequency and intensity of exercise for optimal body composition and QoL.
| Original language | English |
|---|---|
| Publication status | Published - 2018 |
| Event | The 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition: Building the Bridge – Building excellence in clinical nutrition - Sheraton on the Park, Sydney, Australia Duration: 29 Nov 2018 → 1 Dec 2018 Conference number: 44th http://www.auspen2018.com.au/ |
Conference
| Conference | The 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition |
|---|---|
| Abbreviated title | AuSPEN |
| Country/Territory | Australia |
| City | Sydney |
| Period | 29/11/18 → 1/12/18 |
| Internet address |
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Dive into the research topics of 'Systematic review of the effects of exercise and nutrition interventions on body composition in women with metastatic breast cancer'. Together they form a unique fingerprint.Related Projects
- 2 Active
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Oncology Nutrition Research
Isenring, E., Marshall, S., Van der Meij, B., Rigby, R., Teleni, L., Crichton, M. & Tang, X.
1/01/14 → …
Project: Research
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Research by Master of Nutrition and Dietetic Practice Students
Isenring, E., Marshall, S., Reidlinger, D., Kelly, J., Cox, G., Van der Meij, B., MacKenzie-Shalders, K., Mayr, H., Utter, J., Dahl, C., Crichton, M., O'Bryan, K. R., Norris, R., Warner, M., Davidson, A., Naranjo, A., Mahoney, S., Eberhardt, F., Dalwood, P., Lopez, E., Hofto, S., Innerarity, C., So, D., McIntosh, A., Gadd, N., Chan, H. C., Lan, X., Fei, X., Kostjasyn, S., Adhyaru, P., Giang, J., Leung, E. L. Y., Strike, K., Pearcy, J., Somani, A., Wright, C., Matthews, C., Lee, G., Tang, X. & Eso, A.
1/01/14 → 31/12/27
Project: Research
Related Activities
- 1 Non-HDR Student Supervision
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Celia Innerarity - Masters of Nutrition and Dietetic Practice research project
Celia Innerarity (Student ), Amelia Bandera (Student ), Jaimon Kelly (Supervisor), David Honeyman (Researcher) & Barbara Van der Meij (Supervisor)
1 Sept 2017 → 30 Apr 2018Activity: Professional Development, Mentorship, Supervision and Other Activities › Non-HDR Student Supervision