Systematic review of the effects of exercise and nutrition interventions on body composition in women with metastatic breast cancer

Celia Innerarity, Jaimon T Kelly, Barbara S Van der Meij

Research output: Contribution to conferencePosterResearch

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Abstract

Background
Metastatic breast cancer (MBC) affects approximately 20-30 percent of women with breast cancer. Current treatment options improve survival, however disease- or treatment related symptoms and muscle wasting are increasingly common and significantly decrease patients’ quality of life.

Methods
This systematic review aimed to evaluate the evidence for lifestyle interventions on body composition in women with MBC to inform future research. Secondary outcomes of interest were fatigue, quality of life (QoL), survival, and toxicity, and depression. Pubmed, CINAHL, Cochrane Central and EMBASE databases were searched from database inception to July 2018. All prospective randomised and non-randomised studies that investigated the effect of exercise and/or nutrition interventions were included. Two independent reviewers performed the search, extracted data and conducted the analysis.

Results
In total, only 7 studies were eligible for review, of which 3 were randomised controlled trials. No studies were were identified that investigated the effects of lifestyle interventions on body composition in this population. Seven studies reported that exercise interventions, over a minimum duration of 4 weeks, found lower patient-reported fatigue, improved QoL and longer survival. All included studies were judged of low quality (low statistical power, small sample sizes, diverse study designs, and reliance on patient-reported data).

Conclusions
To date, there is insufficient evidence to draw firm conclusions regarding the impact of lifestyle interventions in MBC. Clinical practice is largely based on studies that have been performed in patients receiving curative treatment for breast cancer. Future research demands innovative, high-quality, large sample, randomised controlled trials to inform evidence-based guidelines on diet, mode, frequency and intensity of exercise for optimal body composition and QoL.
Original languageEnglish
Publication statusPublished - 2018
EventThe 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition: Building the Bridge – Building excellence in clinical nutrition - Sheraton on the Park, Sydney, Australia
Duration: 29 Nov 20181 Dec 2018
Conference number: 44th
http://www.auspen2018.com.au/

Conference

ConferenceThe 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition
Abbreviated titleAuSPEN
CountryAustralia
CitySydney
Period29/11/181/12/18
Internet address

Fingerprint

Body Composition
Exercise
Breast Neoplasms
Quality of Life
Life Style
Fatigue
Survival
Randomized Controlled Trials
Databases
PubMed
Sample Size
Therapeutics
Guidelines
Depression
Diet
Muscles
Population

Cite this

Innerarity, C., Kelly, J. T., & Van der Meij, B. S. (2018). Systematic review of the effects of exercise and nutrition interventions on body composition in women with metastatic breast cancer. Poster session presented at The 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition, Sydney, Australia.
Innerarity, Celia ; Kelly, Jaimon T ; Van der Meij, Barbara S. / Systematic review of the effects of exercise and nutrition interventions on body composition in women with metastatic breast cancer. Poster session presented at The 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition, Sydney, Australia.
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title = "Systematic review of the effects of exercise and nutrition interventions on body composition in women with metastatic breast cancer",
abstract = "Background Metastatic breast cancer (MBC) affects approximately 20-30 percent of women with breast cancer. Current treatment options improve survival, however disease- or treatment related symptoms and muscle wasting are increasingly common and significantly decrease patients’ quality of life. MethodsThis systematic review aimed to evaluate the evidence for lifestyle interventions on body composition in women with MBC to inform future research. Secondary outcomes of interest were fatigue, quality of life (QoL), survival, and toxicity, and depression. Pubmed, CINAHL, Cochrane Central and EMBASE databases were searched from database inception to July 2018. All prospective randomised and non-randomised studies that investigated the effect of exercise and/or nutrition interventions were included. Two independent reviewers performed the search, extracted data and conducted the analysis. Results In total, only 7 studies were eligible for review, of which 3 were randomised controlled trials. No studies were were identified that investigated the effects of lifestyle interventions on body composition in this population. Seven studies reported that exercise interventions, over a minimum duration of 4 weeks, found lower patient-reported fatigue, improved QoL and longer survival. All included studies were judged of low quality (low statistical power, small sample sizes, diverse study designs, and reliance on patient-reported data). Conclusions To date, there is insufficient evidence to draw firm conclusions regarding the impact of lifestyle interventions in MBC. Clinical practice is largely based on studies that have been performed in patients receiving curative treatment for breast cancer. Future research demands innovative, high-quality, large sample, randomised controlled trials to inform evidence-based guidelines on diet, mode, frequency and intensity of exercise for optimal body composition and QoL.",
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Innerarity, C, Kelly, JT & Van der Meij, BS 2018, 'Systematic review of the effects of exercise and nutrition interventions on body composition in women with metastatic breast cancer' The 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition, Sydney, Australia, 29/11/18 - 1/12/18, .

Systematic review of the effects of exercise and nutrition interventions on body composition in women with metastatic breast cancer. / Innerarity, Celia; Kelly, Jaimon T; Van der Meij, Barbara S.

2018. Poster session presented at The 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition, Sydney, Australia.

Research output: Contribution to conferencePosterResearch

TY - CONF

T1 - Systematic review of the effects of exercise and nutrition interventions on body composition in women with metastatic breast cancer

AU - Innerarity, Celia

AU - Kelly, Jaimon T

AU - Van der Meij, Barbara S

PY - 2018

Y1 - 2018

N2 - Background Metastatic breast cancer (MBC) affects approximately 20-30 percent of women with breast cancer. Current treatment options improve survival, however disease- or treatment related symptoms and muscle wasting are increasingly common and significantly decrease patients’ quality of life. MethodsThis systematic review aimed to evaluate the evidence for lifestyle interventions on body composition in women with MBC to inform future research. Secondary outcomes of interest were fatigue, quality of life (QoL), survival, and toxicity, and depression. Pubmed, CINAHL, Cochrane Central and EMBASE databases were searched from database inception to July 2018. All prospective randomised and non-randomised studies that investigated the effect of exercise and/or nutrition interventions were included. Two independent reviewers performed the search, extracted data and conducted the analysis. Results In total, only 7 studies were eligible for review, of which 3 were randomised controlled trials. No studies were were identified that investigated the effects of lifestyle interventions on body composition in this population. Seven studies reported that exercise interventions, over a minimum duration of 4 weeks, found lower patient-reported fatigue, improved QoL and longer survival. All included studies were judged of low quality (low statistical power, small sample sizes, diverse study designs, and reliance on patient-reported data). Conclusions To date, there is insufficient evidence to draw firm conclusions regarding the impact of lifestyle interventions in MBC. Clinical practice is largely based on studies that have been performed in patients receiving curative treatment for breast cancer. Future research demands innovative, high-quality, large sample, randomised controlled trials to inform evidence-based guidelines on diet, mode, frequency and intensity of exercise for optimal body composition and QoL.

AB - Background Metastatic breast cancer (MBC) affects approximately 20-30 percent of women with breast cancer. Current treatment options improve survival, however disease- or treatment related symptoms and muscle wasting are increasingly common and significantly decrease patients’ quality of life. MethodsThis systematic review aimed to evaluate the evidence for lifestyle interventions on body composition in women with MBC to inform future research. Secondary outcomes of interest were fatigue, quality of life (QoL), survival, and toxicity, and depression. Pubmed, CINAHL, Cochrane Central and EMBASE databases were searched from database inception to July 2018. All prospective randomised and non-randomised studies that investigated the effect of exercise and/or nutrition interventions were included. Two independent reviewers performed the search, extracted data and conducted the analysis. Results In total, only 7 studies were eligible for review, of which 3 were randomised controlled trials. No studies were were identified that investigated the effects of lifestyle interventions on body composition in this population. Seven studies reported that exercise interventions, over a minimum duration of 4 weeks, found lower patient-reported fatigue, improved QoL and longer survival. All included studies were judged of low quality (low statistical power, small sample sizes, diverse study designs, and reliance on patient-reported data). Conclusions To date, there is insufficient evidence to draw firm conclusions regarding the impact of lifestyle interventions in MBC. Clinical practice is largely based on studies that have been performed in patients receiving curative treatment for breast cancer. Future research demands innovative, high-quality, large sample, randomised controlled trials to inform evidence-based guidelines on diet, mode, frequency and intensity of exercise for optimal body composition and QoL.

M3 - Poster

ER -

Innerarity C, Kelly JT, Van der Meij BS. Systematic review of the effects of exercise and nutrition interventions on body composition in women with metastatic breast cancer. 2018. Poster session presented at The 44th Annual Scientific Meeting of the Australasian Society of Parenteral and Enteral Nutrition, Sydney, Australia.