Sustaining knowledge translation interventions for chronic disease management in older adults: Protocol for a systematic review and network meta-analysis

Andrea C. Tricco, Julia E. Moore, Nicole Beben, Ross C. Brownson, David A. Chambers, Lisa R. Dolovich, Annemarie Edwards, Lee Fairclough, Paul P. Glasziou, Ian D. Graham, Brenda R. Hemmelgarn, Bev Holmes, Wanrudee Isaranuwatchai, Chantelle C. Lachance, France Legare, Jessie McGowan, Sumit R. Majumdar, Justin Presseau, Janet E. Squires, Henry T. Stelfox & 5 others Lisa Strifler, Kristine Thompson, Trudy Van Der Weijden, Areti Angeliki Veroniki, Sharon E. Straus

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Abstract

Background: Failure to sustain knowledge translation (KT) interventions impacts patients and health systems, diminishing confidence in future implementation. Sustaining KT interventions used to implement chronic disease management (CDM) interventions is of critical importance given the proportion of older adults with chronic diseases and their need for ongoing care. Our objectives are to (1) complete a systematic review and network meta-analysis of the effectiveness and cost-effectiveness of sustainability of KT interventions that target CDM for end-users including older patients, clinicians, public health officials, health services managers and policy-makers on health care outcomes beyond 1 year after implementation or the termination of initial project funding and (2) use the results of this review to complete an economic analysis of the interventions identified to be effective. Methods: For objective 1, comprehensive searches of relevant electronic databases (e.g. MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials), websites of health care provider organisations and funding agencies will be conducted. We will include randomised controlled trials (RCTs) examining the impact of a KT intervention targeting CDM in adults aged 65 years and older. To examine cost, economic studies (e.g. cost, cost-effectiveness analyses) will be included. Our primary outcome will be the sustainability of the delivery of the KT intervention beyond 1 year after implementation or termination of study funding. Secondary outcomes will include behaviour changes at the level of the patient (e.g. symptom management) and clinician (e.g. physician test ordering) and health system (e.g. cost, hospital admissions). Article screening, data abstraction and risk of bias assessment will be completed independently by two reviewers. Using established methods, if the assumption of transitivity is valid and the evidence forms a connected network, Bayesian random-effects pairwise and network meta-analysis will be conducted. For objective 2, we will build a decision analytic model comparing effective interventions to estimate an incremental cost-effectiveness ratio. Discussion: Our results will inform knowledge users (e.g. patients, clinicians, policy-makers) regarding the sustainability of KT interventions for CDM. Dissemination plan of our results will be tailored to end-users and include passive (e.g. publications, website posting) and interactive (e.g. knowledge exchange events with stakeholders) strategies.

Original languageEnglish
Article number140
JournalSystematic Reviews
Volume7
Issue number1
DOIs
Publication statusPublished - 15 Sep 2018
Externally publishedYes

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Translational Medical Research
Disease Management
Chronic Disease
Cost-Benefit Analysis
Administrative Personnel
Economics
Costs and Cost Analysis
Hospital Costs
Health
Health Policy
MEDLINE
Health Personnel
Health Services
Publications
Network Meta-Analysis
Randomized Controlled Trials
Public Health
Organizations
Databases
Delivery of Health Care

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Tricco, Andrea C. ; Moore, Julia E. ; Beben, Nicole ; Brownson, Ross C. ; Chambers, David A. ; Dolovich, Lisa R. ; Edwards, Annemarie ; Fairclough, Lee ; Glasziou, Paul P. ; Graham, Ian D. ; Hemmelgarn, Brenda R. ; Holmes, Bev ; Isaranuwatchai, Wanrudee ; Lachance, Chantelle C. ; Legare, France ; McGowan, Jessie ; Majumdar, Sumit R. ; Presseau, Justin ; Squires, Janet E. ; Stelfox, Henry T. ; Strifler, Lisa ; Thompson, Kristine ; Van Der Weijden, Trudy ; Veroniki, Areti Angeliki ; Straus, Sharon E. / Sustaining knowledge translation interventions for chronic disease management in older adults : Protocol for a systematic review and network meta-analysis . In: Systematic Reviews. 2018 ; Vol. 7, No. 1.
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abstract = "Background: Failure to sustain knowledge translation (KT) interventions impacts patients and health systems, diminishing confidence in future implementation. Sustaining KT interventions used to implement chronic disease management (CDM) interventions is of critical importance given the proportion of older adults with chronic diseases and their need for ongoing care. Our objectives are to (1) complete a systematic review and network meta-analysis of the effectiveness and cost-effectiveness of sustainability of KT interventions that target CDM for end-users including older patients, clinicians, public health officials, health services managers and policy-makers on health care outcomes beyond 1 year after implementation or the termination of initial project funding and (2) use the results of this review to complete an economic analysis of the interventions identified to be effective. Methods: For objective 1, comprehensive searches of relevant electronic databases (e.g. MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials), websites of health care provider organisations and funding agencies will be conducted. We will include randomised controlled trials (RCTs) examining the impact of a KT intervention targeting CDM in adults aged 65 years and older. To examine cost, economic studies (e.g. cost, cost-effectiveness analyses) will be included. Our primary outcome will be the sustainability of the delivery of the KT intervention beyond 1 year after implementation or termination of study funding. Secondary outcomes will include behaviour changes at the level of the patient (e.g. symptom management) and clinician (e.g. physician test ordering) and health system (e.g. cost, hospital admissions). Article screening, data abstraction and risk of bias assessment will be completed independently by two reviewers. Using established methods, if the assumption of transitivity is valid and the evidence forms a connected network, Bayesian random-effects pairwise and network meta-analysis will be conducted. For objective 2, we will build a decision analytic model comparing effective interventions to estimate an incremental cost-effectiveness ratio. Discussion: Our results will inform knowledge users (e.g. patients, clinicians, policy-makers) regarding the sustainability of KT interventions for CDM. Dissemination plan of our results will be tailored to end-users and include passive (e.g. publications, website posting) and interactive (e.g. knowledge exchange events with stakeholders) strategies.",
author = "Tricco, {Andrea C.} and Moore, {Julia E.} and Nicole Beben and Brownson, {Ross C.} and Chambers, {David A.} and Dolovich, {Lisa R.} and Annemarie Edwards and Lee Fairclough and Glasziou, {Paul P.} and Graham, {Ian D.} and Hemmelgarn, {Brenda R.} and Bev Holmes and Wanrudee Isaranuwatchai and Lachance, {Chantelle C.} and France Legare and Jessie McGowan and Majumdar, {Sumit R.} and Justin Presseau and Squires, {Janet E.} and Stelfox, {Henry T.} and Lisa Strifler and Kristine Thompson and {Van Der Weijden}, Trudy and Veroniki, {Areti Angeliki} and Straus, {Sharon E.}",
year = "2018",
month = "9",
day = "15",
doi = "10.1186/s13643-018-0808-4",
language = "English",
volume = "7",
journal = "Systematic Reviews",
issn = "2046-4053",
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Tricco, AC, Moore, JE, Beben, N, Brownson, RC, Chambers, DA, Dolovich, LR, Edwards, A, Fairclough, L, Glasziou, PP, Graham, ID, Hemmelgarn, BR, Holmes, B, Isaranuwatchai, W, Lachance, CC, Legare, F, McGowan, J, Majumdar, SR, Presseau, J, Squires, JE, Stelfox, HT, Strifler, L, Thompson, K, Van Der Weijden, T, Veroniki, AA & Straus, SE 2018, 'Sustaining knowledge translation interventions for chronic disease management in older adults: Protocol for a systematic review and network meta-analysis ' Systematic Reviews, vol. 7, no. 1, 140. https://doi.org/10.1186/s13643-018-0808-4

Sustaining knowledge translation interventions for chronic disease management in older adults : Protocol for a systematic review and network meta-analysis . / Tricco, Andrea C.; Moore, Julia E.; Beben, Nicole; Brownson, Ross C.; Chambers, David A.; Dolovich, Lisa R.; Edwards, Annemarie; Fairclough, Lee; Glasziou, Paul P.; Graham, Ian D.; Hemmelgarn, Brenda R.; Holmes, Bev; Isaranuwatchai, Wanrudee; Lachance, Chantelle C.; Legare, France; McGowan, Jessie; Majumdar, Sumit R.; Presseau, Justin; Squires, Janet E.; Stelfox, Henry T.; Strifler, Lisa; Thompson, Kristine; Van Der Weijden, Trudy; Veroniki, Areti Angeliki; Straus, Sharon E.

In: Systematic Reviews, Vol. 7, No. 1, 140, 15.09.2018.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Sustaining knowledge translation interventions for chronic disease management in older adults

T2 - Protocol for a systematic review and network meta-analysis

AU - Tricco, Andrea C.

AU - Moore, Julia E.

AU - Beben, Nicole

AU - Brownson, Ross C.

AU - Chambers, David A.

AU - Dolovich, Lisa R.

AU - Edwards, Annemarie

AU - Fairclough, Lee

AU - Glasziou, Paul P.

AU - Graham, Ian D.

AU - Hemmelgarn, Brenda R.

AU - Holmes, Bev

AU - Isaranuwatchai, Wanrudee

AU - Lachance, Chantelle C.

AU - Legare, France

AU - McGowan, Jessie

AU - Majumdar, Sumit R.

AU - Presseau, Justin

AU - Squires, Janet E.

AU - Stelfox, Henry T.

AU - Strifler, Lisa

AU - Thompson, Kristine

AU - Van Der Weijden, Trudy

AU - Veroniki, Areti Angeliki

AU - Straus, Sharon E.

PY - 2018/9/15

Y1 - 2018/9/15

N2 - Background: Failure to sustain knowledge translation (KT) interventions impacts patients and health systems, diminishing confidence in future implementation. Sustaining KT interventions used to implement chronic disease management (CDM) interventions is of critical importance given the proportion of older adults with chronic diseases and their need for ongoing care. Our objectives are to (1) complete a systematic review and network meta-analysis of the effectiveness and cost-effectiveness of sustainability of KT interventions that target CDM for end-users including older patients, clinicians, public health officials, health services managers and policy-makers on health care outcomes beyond 1 year after implementation or the termination of initial project funding and (2) use the results of this review to complete an economic analysis of the interventions identified to be effective. Methods: For objective 1, comprehensive searches of relevant electronic databases (e.g. MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials), websites of health care provider organisations and funding agencies will be conducted. We will include randomised controlled trials (RCTs) examining the impact of a KT intervention targeting CDM in adults aged 65 years and older. To examine cost, economic studies (e.g. cost, cost-effectiveness analyses) will be included. Our primary outcome will be the sustainability of the delivery of the KT intervention beyond 1 year after implementation or termination of study funding. Secondary outcomes will include behaviour changes at the level of the patient (e.g. symptom management) and clinician (e.g. physician test ordering) and health system (e.g. cost, hospital admissions). Article screening, data abstraction and risk of bias assessment will be completed independently by two reviewers. Using established methods, if the assumption of transitivity is valid and the evidence forms a connected network, Bayesian random-effects pairwise and network meta-analysis will be conducted. For objective 2, we will build a decision analytic model comparing effective interventions to estimate an incremental cost-effectiveness ratio. Discussion: Our results will inform knowledge users (e.g. patients, clinicians, policy-makers) regarding the sustainability of KT interventions for CDM. Dissemination plan of our results will be tailored to end-users and include passive (e.g. publications, website posting) and interactive (e.g. knowledge exchange events with stakeholders) strategies.

AB - Background: Failure to sustain knowledge translation (KT) interventions impacts patients and health systems, diminishing confidence in future implementation. Sustaining KT interventions used to implement chronic disease management (CDM) interventions is of critical importance given the proportion of older adults with chronic diseases and their need for ongoing care. Our objectives are to (1) complete a systematic review and network meta-analysis of the effectiveness and cost-effectiveness of sustainability of KT interventions that target CDM for end-users including older patients, clinicians, public health officials, health services managers and policy-makers on health care outcomes beyond 1 year after implementation or the termination of initial project funding and (2) use the results of this review to complete an economic analysis of the interventions identified to be effective. Methods: For objective 1, comprehensive searches of relevant electronic databases (e.g. MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials), websites of health care provider organisations and funding agencies will be conducted. We will include randomised controlled trials (RCTs) examining the impact of a KT intervention targeting CDM in adults aged 65 years and older. To examine cost, economic studies (e.g. cost, cost-effectiveness analyses) will be included. Our primary outcome will be the sustainability of the delivery of the KT intervention beyond 1 year after implementation or termination of study funding. Secondary outcomes will include behaviour changes at the level of the patient (e.g. symptom management) and clinician (e.g. physician test ordering) and health system (e.g. cost, hospital admissions). Article screening, data abstraction and risk of bias assessment will be completed independently by two reviewers. Using established methods, if the assumption of transitivity is valid and the evidence forms a connected network, Bayesian random-effects pairwise and network meta-analysis will be conducted. For objective 2, we will build a decision analytic model comparing effective interventions to estimate an incremental cost-effectiveness ratio. Discussion: Our results will inform knowledge users (e.g. patients, clinicians, policy-makers) regarding the sustainability of KT interventions for CDM. Dissemination plan of our results will be tailored to end-users and include passive (e.g. publications, website posting) and interactive (e.g. knowledge exchange events with stakeholders) strategies.

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U2 - 10.1186/s13643-018-0808-4

DO - 10.1186/s13643-018-0808-4

M3 - Review article

VL - 7

JO - Systematic Reviews

JF - Systematic Reviews

SN - 2046-4053

IS - 1

M1 - 140

ER -