TY - JOUR
T1 - Success of community-based directly observed anti-tuberculosis treatment in Mongolia
AU - Dobler, C. C.
AU - Korver, S.
AU - Batbayar, O.
AU - Oyuntsetseg, S.
AU - Tsolmon, B.
AU - Wright, C.
AU - Solongo, B.
AU - Marais, B. J.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - BACKGROUND: Many countries restrict access to directly observed therapy (DOT) for tuberculosis (TB) to government health facilities. More innovative approaches are required to reduce non-adherence, improve patient outcomes and limit the risk of selecting drugresistant strains. METHODS: We performed a retrospective cohort study in sputum smear-positive patients treated with community- based DOT (home-based DOT or 'lunch' DOT, whereby DOT is provided with a free daily meal once sputum smear conversion has been documented), and conventional clinic-based DOT in Ulaanbaatar, the capital of Mongolia, in 2010-2011. We compared treatment success using community-based home DOT vs. conventional clinic DOT and describe treatment completion rates using lunch DOT. RESULT S : The overall treatment success among new sputum smear-positive TB patients was 85.1% (1505/ 1768). Patients receiving community DOT had higher cure rates (294/327, 89.9% vs. 1112/1441, 77.2%; aOR 2.66, 95%CI 1.81-3.90) and higher treatment success (306/327, 93.6% vs. 1199/1441, 83.2%; aOR 2.95, 95%CI 1.85-4.71, P < 0.001) than those treated with clinic DOT. Apart from one death, treatment completion was 100% among patients who received lunch DOT after sputum smear conversion. CONCLUSIONS: Community DOTimproved treatment success in Ulaanbaatar, Mongolia. It should now be scaled up to be made available for more patients and in all regions of the country.
AB - BACKGROUND: Many countries restrict access to directly observed therapy (DOT) for tuberculosis (TB) to government health facilities. More innovative approaches are required to reduce non-adherence, improve patient outcomes and limit the risk of selecting drugresistant strains. METHODS: We performed a retrospective cohort study in sputum smear-positive patients treated with community- based DOT (home-based DOT or 'lunch' DOT, whereby DOT is provided with a free daily meal once sputum smear conversion has been documented), and conventional clinic-based DOT in Ulaanbaatar, the capital of Mongolia, in 2010-2011. We compared treatment success using community-based home DOT vs. conventional clinic DOT and describe treatment completion rates using lunch DOT. RESULT S : The overall treatment success among new sputum smear-positive TB patients was 85.1% (1505/ 1768). Patients receiving community DOT had higher cure rates (294/327, 89.9% vs. 1112/1441, 77.2%; aOR 2.66, 95%CI 1.81-3.90) and higher treatment success (306/327, 93.6% vs. 1199/1441, 83.2%; aOR 2.95, 95%CI 1.85-4.71, P < 0.001) than those treated with clinic DOT. Apart from one death, treatment completion was 100% among patients who received lunch DOT after sputum smear conversion. CONCLUSIONS: Community DOTimproved treatment success in Ulaanbaatar, Mongolia. It should now be scaled up to be made available for more patients and in all regions of the country.
UR - http://www.scopus.com/inward/record.url?scp=84929391998&partnerID=8YFLogxK
U2 - 10.5588/ijtld.14.0927
DO - 10.5588/ijtld.14.0927
M3 - Article
C2 - 25946355
AN - SCOPUS:84929391998
SN - 1027-3719
VL - 19
SP - 657
EP - 662
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
IS - 6
ER -
