Subthalamic stimulation affects homophone meaning generation in Parkinson's disease

Joanna E. Castner, David A. Copland, Peter A. Silburn, Terry J. Coyne, Felicity Sinclair, Helen J. Chenery*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) in individuals with Parkinson's disease (PD) has often been associated with reduced verbal fluency performance. This study aimed to directly assess semantic switching as a function of STN stimulation in PD participants with the Homophone Meaning Generation Test (HMGT). Seventeen participants with PD who had received STN DBS completed the HMGT in on and off stimulation conditions. Twenty-one non-neurologically impaired participants acted as controls. PD participants (in both on and off stimulation conditions) generated significantly fewer meanings than control participants and consistent with the previous reports of verbal fluency impairment, PD participants produced fewer definitions in the on stimulation condition. PD participants (in both on and off stimulation conditions) also had greater difficulty generating definitions for nonhomographic homophones compared with homographic homographs. The results of this study indicate that STN stimulation exacerbates impairment in semantic switching.

Original languageEnglish
Pages (from-to)890-894
Number of pages5
JournalJournal of the International Neuropsychological Society
Volume14
Issue number5
DOIs
Publication statusPublished - 2008
Externally publishedYes

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Castner, J. E., Copland, D. A., Silburn, P. A., Coyne, T. J., Sinclair, F., & Chenery, H. J. (2008). Subthalamic stimulation affects homophone meaning generation in Parkinson's disease. Journal of the International Neuropsychological Society, 14(5), 890-894. https://doi.org/10.1017/S1355617708081046