Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population

Jason Mackenzie; Lotti Tajouri; Attila L Szvetko; Verena Weth; Julie Moreau; Judith M Greer; Peter A Csurhes; Michael P. Pender; Lyn R. Griffiths

doi:10.1016/j.jns.2009.01.026

Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population

Jason Mackenzie^*, Lotti Tajouri, Attila L Szvetko, Verena Weth, Julie Moreau, Judith M Greer, Peter A Csurhes, Michael P. Pender, Lyn R. Griffiths

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Objective: To examine a polymorphism within the 3' untranslated region of the leukemia inhibitory factor gene for an association with multiple sclerosis within an Australian case-control population.

Methods: A test group of 121 unrelated multiple sclerosis patients, of Caucasian origin, and 121 controls, matched for ethnicity, sex and age (+/-5 years) were included in the study. The LIF 3' UTR Stul polymorphism was genotyped by restriction fragment length polymorphism analysis. Statistical analysis of genotype and allele frequencies included Hardy-Weinberg law and conventional contingency table analysis incorporating the standard chi-squared test for independence.

Results: Allelic and genotype frequencies did not demonstrate a significant association between the case and control groups for the tested LIF 3' UTR Stul polymorphism.

Conclusion: The results indicate that the LIF 31 UTR Stul polymorphism is not associated with multiple sclerosis, however we cannot exclude the hypothesis that other polymorphic alleles of LIF could be implicated in MS susceptibility. (C) 2009 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	62-64
Number of pages	3
Journal	Journal of the Neurological Sciences
Volume	280
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2009.01.026
Publication status	Published - 15 May 2009
Externally published	Yes

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title = "Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population",

abstract = "Objective: To examine a polymorphism within the 3' untranslated region of the leukemia inhibitory factor gene for an association with multiple sclerosis within an Australian case-control population.Methods: A test group of 121 unrelated multiple sclerosis patients, of Caucasian origin, and 121 controls, matched for ethnicity, sex and age (+/-5 years) were included in the study. The LIF 3' UTR Stul polymorphism was genotyped by restriction fragment length polymorphism analysis. Statistical analysis of genotype and allele frequencies included Hardy-Weinberg law and conventional contingency table analysis incorporating the standard chi-squared test for independence.Results: Allelic and genotype frequencies did not demonstrate a significant association between the case and control groups for the tested LIF 3' UTR Stul polymorphism.Conclusion: The results indicate that the LIF 31 UTR Stul polymorphism is not associated with multiple sclerosis, however we cannot exclude the hypothesis that other polymorphic alleles of LIF could be implicated in MS susceptibility. (C) 2009 Elsevier B.V. All rights reserved.",

author = "Jason Mackenzie and Lotti Tajouri and Szvetko, {Attila L} and Verena Weth and Julie Moreau and Greer, {Judith M} and Csurhes, {Peter A} and Pender, {Michael P.} and Griffiths, {Lyn R.}",

year = "2009",

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day = "15",

doi = "10.1016/j.jns.2009.01.026",

language = "English",

volume = "280",

pages = "62--64",

journal = "Journal of the Neurological Sciences",

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number = "1-2",

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TY - JOUR

T1 - Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population

AU - Mackenzie, Jason

AU - Tajouri, Lotti

AU - Szvetko, Attila L

AU - Weth, Verena

AU - Moreau, Julie

AU - Greer, Judith M

AU - Csurhes, Peter A

AU - Pender, Michael P.

AU - Griffiths, Lyn R.

PY - 2009/5/15

Y1 - 2009/5/15

N2 - Objective: To examine a polymorphism within the 3' untranslated region of the leukemia inhibitory factor gene for an association with multiple sclerosis within an Australian case-control population.Methods: A test group of 121 unrelated multiple sclerosis patients, of Caucasian origin, and 121 controls, matched for ethnicity, sex and age (+/-5 years) were included in the study. The LIF 3' UTR Stul polymorphism was genotyped by restriction fragment length polymorphism analysis. Statistical analysis of genotype and allele frequencies included Hardy-Weinberg law and conventional contingency table analysis incorporating the standard chi-squared test for independence.Results: Allelic and genotype frequencies did not demonstrate a significant association between the case and control groups for the tested LIF 3' UTR Stul polymorphism.Conclusion: The results indicate that the LIF 31 UTR Stul polymorphism is not associated with multiple sclerosis, however we cannot exclude the hypothesis that other polymorphic alleles of LIF could be implicated in MS susceptibility. (C) 2009 Elsevier B.V. All rights reserved.

AB - Objective: To examine a polymorphism within the 3' untranslated region of the leukemia inhibitory factor gene for an association with multiple sclerosis within an Australian case-control population.Methods: A test group of 121 unrelated multiple sclerosis patients, of Caucasian origin, and 121 controls, matched for ethnicity, sex and age (+/-5 years) were included in the study. The LIF 3' UTR Stul polymorphism was genotyped by restriction fragment length polymorphism analysis. Statistical analysis of genotype and allele frequencies included Hardy-Weinberg law and conventional contingency table analysis incorporating the standard chi-squared test for independence.Results: Allelic and genotype frequencies did not demonstrate a significant association between the case and control groups for the tested LIF 3' UTR Stul polymorphism.Conclusion: The results indicate that the LIF 31 UTR Stul polymorphism is not associated with multiple sclerosis, however we cannot exclude the hypothesis that other polymorphic alleles of LIF could be implicated in MS susceptibility. (C) 2009 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.jns.2009.01.026

DO - 10.1016/j.jns.2009.01.026

M3 - Article

SN - 0022-510X

VL - 280

SP - 62

EP - 64

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

IS - 1-2

ER -

Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population

Abstract

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