Abstract
Abstract #1063
CaP coating on melt electrowritten (MEW) substrates demonstrated itself as a potential candidate for bone regeneration
due to mimick the natural bone tissue. It increased the osteoblast cells - implanted scaffolds interactions and improved
bone ingrowth. This study aims to evaluate the stability and structural properties of CaP coating on melt electrowritten PCL
scaffolds following pre-treatments of Ar- O2 plasma and NaOH solution to improve the wettability.
The plasma-treated fibers were uniformly coated after one hour. The surface wettability enhanced through the
mineralization of both plasma and NaOH pre-treated scaffolds. Mechanical properties of the scaffolds degraded through
the plasma and NaOH treatment. However, tensile stability was improved following mineralization in plasma-treated
scaffolds due to the smaller crystal size and a dense CaP layer, which leads to the higher solubility. We demonstrated that
the plasma pre-treated mineralized surface is stable enough to be potentially useful for the further development of bone
regeneration. and could successfully direct cells toward an osteogenic lineage with resulting mineralization.
CaP coating on melt electrowritten (MEW) substrates demonstrated itself as a potential candidate for bone regeneration
due to mimick the natural bone tissue. It increased the osteoblast cells - implanted scaffolds interactions and improved
bone ingrowth. This study aims to evaluate the stability and structural properties of CaP coating on melt electrowritten PCL
scaffolds following pre-treatments of Ar- O2 plasma and NaOH solution to improve the wettability.
The plasma-treated fibers were uniformly coated after one hour. The surface wettability enhanced through the
mineralization of both plasma and NaOH pre-treated scaffolds. Mechanical properties of the scaffolds degraded through
the plasma and NaOH treatment. However, tensile stability was improved following mineralization in plasma-treated
scaffolds due to the smaller crystal size and a dense CaP layer, which leads to the higher solubility. We demonstrated that
the plasma pre-treated mineralized surface is stable enough to be potentially useful for the further development of bone
regeneration. and could successfully direct cells toward an osteogenic lineage with resulting mineralization.
| Original language | English |
|---|---|
| Publication status | Published - 4 May 2021 |
| Externally published | Yes |
| Event | 6th world congress of the Tissue Engineering and Regenerative Medicine International Society: Biologically inspired technology driven regenerative medicine - VIRTUAL EVENT, Maastricht, Netherlands Duration: 15 Nov 2019 → 19 Nov 2019 Conference number: 6th https://termis.org/WC2021 |
Conference
| Conference | 6th world congress of the Tissue Engineering and Regenerative Medicine International Society |
|---|---|
| Abbreviated title | TERMIS 2021 |
| Country/Territory | Netherlands |
| City | Maastricht |
| Period | 15/11/19 → 19/11/19 |
| Internet address |