Abstract
Introduction. In bladder overactivity increased spontaneous contractions (SCs) may underlie abnormal increases in intravesical pressure, leading to urgency, frequency and incontinence. SCs are also increased in models of bladder dysfunction, including the diabetic rat (Stevens et al., 2006; Vahabi et al. 2007), possibly due to leakage of acetylcholine from intramural nerves (Ng et al. 2006) or the mucosa.
Aim. To study cholinergic modulation and the role of the mucosa on SCs in bladder strips from diabetic rats.
Methods. Intact and mucosa-denuded bladder strips, from male Wistar rats, 1- and 12-weeks following streptozotocin administration (65mg/kg, i.p.) or age-matched controls, were mounted in Krebs-bicarbonate solution (2g tension, 37°C). SCs were induced by carbachol (CCH) (0.05-0.5ìM), and amplitude and frequency of SCs measured.
Aim. To study cholinergic modulation and the role of the mucosa on SCs in bladder strips from diabetic rats.
Methods. Intact and mucosa-denuded bladder strips, from male Wistar rats, 1- and 12-weeks following streptozotocin administration (65mg/kg, i.p.) or age-matched controls, were mounted in Krebs-bicarbonate solution (2g tension, 37°C). SCs were induced by carbachol (CCH) (0.05-0.5ìM), and amplitude and frequency of SCs measured.
| Original language | English |
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| Pages | 13-13 |
| Number of pages | 1 |
| Publication status | Published - 2010 |
| Event | ASCEPT 44th Annual Scientific Meeting 2010 : Found in Translation: Integrated Approaches to Drug Development - Melbourne , Australia Duration: 28 Nov 2010 → 1 Dec 2010 http://ascept.eproceedings.com.au/ |
Conference
| Conference | ASCEPT 44th Annual Scientific Meeting 2010 |
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| Abbreviated title | ASCEPT |
| Country/Territory | Australia |
| City | Melbourne |
| Period | 28/11/10 → 1/12/10 |
| Internet address |
